Dermal exposure to drilling fluids and crude oil is an exposure route of concern although there have been no published studies describing sampling methods or reporting dermal exposure measurements. We describe a study that aimed to evaluate further a developed wipe sampling method for assessing dermal exposure to drilling fluid and crude oil, as well as to investigate the feasibility of using an interception cotton glove sampler for the hands/wrists. A direct comparison of the wipe and interception method was also completed using surrogate human skin and a direct surface contact exposure situation. The wipe and interception sampling methods were evaluated using an oil-based drilling fluid and crude oil. Overall, acceptable recovery and sampling efficiencies were reported for both methods and both were found to show satisfactory storage stability for 1 and 7 days, although there appeared to be some loss over 14 days. The results from the side-by-side direct surface contact experiments revealed that much higher recoveries of both fluids were measured on the glove samples than on wipe samples (on average 2.5 times higher). Both evaluated sampling methods were found to be suitable for use in assessing dermal exposure to oil based drilling fluids however the comparison study clearly illustrated that the interception technique over-estimated dermal exposure. Further comparison of the two dermal sampling methods using additional exposure situations such as immersion or deposition, as well as a field evaluation, is warranted to confirm their appropriateness and suitability to assess dermal exposure to drilling fluids and crude oil in the working environment. This information, with due consideration of the sampling strategies aims and objectives, will help facilitate dermal sampler selection.