World Population Research Articles

Safety and Efficacy of Ritlecitinib for the Treatment of Patients with Alopecia Areata: A Systematic Review and Meta-Analysis of Controlled Trials

Background: Alopecia areata (AA) typically presents as round patches of hair loss (e.g., scalp, eyebrow/eyelash, and body), has an unpredictable disease course, and may relapse and remit. AA is a condition with a lifetime risk of approximately 2% in the global population with an annual incidence rate ranging from 2.53 to 26 per 100,000. This comprehensive systematic review and meta-analysis was performed to determine the safety and efficacy of Ritlecitinib in patients with AA. Methods: A systematic search was conducted in PubMed and Cochrane CENTRAL Library for randomized controlled trials (RCTs). We used mean difference with 95% confidence intervals to assess the effectiveness and odds ratio to assess the safety profile. A total of 65 publications were identified through a database search. Following two stages of screening, we included 13 publications. All the studies were parallel and double-blind RCTs and published between 2020 and 2022. Results: Our analysis revealed a significant reduction in SALT score at week 12 and week 24 of (−17.43 [−24.67 to −10.20]; p < 0.0001) and (−20.95 [−29.01 to −12.89]; p < 0.0001), respectively, in patients treated with Ritlecitinib compared to placebo. Furthermore, a significant improvement in PGIC score at week 24 was observed. Additionally, Ritlecitinib revealed a slightly higher reduction in AASIS score compared to placebo; however, this difference was statistically non-significant. Notably, the Ritlecitinib group experienced a higher frequency of headaches, acne and nasopharyngitis compared to placebo, while the placebo group reported a greater occurrence of serious adverse events compared to the Ritlecitinib group. This higher rate of serious events in the placebo arm could be explained by the placebo effect, although these differences were statistically non-significant. Conclusions: These findings suggest that Ritlecitinib holds promise as an effective treatment for AA with an acceptable safety profile, warranting further investigation in larger cohorts and long-term studies.

Co-infection of intestinal protozoa and intestinal parasites with Helicobacter pylori among HIV AIDS patients at Jimma Medical Center, Ethiopia.

Co-infection of intestinal protozoa and intestinal parasites with Helicobacter pylori among HIV AIDS patients at Jimma Medical Center, Ethiopia.

Gender Inequality, Deprivation and Seclusion of Indian Muslim Women

Abstract The number of Muslims in the world is projected to increase rapidly to about 2.8 billion in 2050, expecting to rise from 23% of the current world population to 30% in 2050 (Pew Research Centre, 2015). In light of this, there are already almost a billion Muslim women, making up 12% of the population around the world. In the case of India, mainstream society knows little about Muslim women’s lives, their diversity, their religious and constitutional rights and socio-legal movements, among them, those concerning liberation, equity and justice. Their under-representation in public life contributes to the inadequacy of data on their social life in the 21st century. Women from marginalized communities are often under-represented in research, a fact which reveals how their lived realities are ignored in the academic community. Likewise, the global political discourse that frequently engages with Muslim women has a long and inglorious stereotype of depicting them as a passive, secluded and oppressed entity. The outcome of the present study, however, contradicts many of the prevailing assumptions, offering an entirely different interpretation of reality on the ground. This article delves into the contemporary profile of Indian Muslim women through the anthropological lens, presenting the intricate and diverse ways in which they face marginalization while grappling with the demands of daily life. This piece further reveals how they negotiate feminism’s boundaries through their social and political activism, presenting themselves as prominent figures in the public sphere by combating racial and cultural prejudices. Their participation is relevant because it challenges the stereotypes of women as ‘passive’ and/or ‘inferior’ which are pertinent in light of the increasing gendered Islamophobia towards Muslim women on a global level. Finally, it aims to clarify the accusations against Islam in the context of women’s rights and feminism today.

Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.

As the global population ages, the prevalence of neurodegenerative disorders is fast increasing. This neurodegeneration as well as other central nervous system (CNS) injuries cause permanent disabilities. Thus, generation of new neurons is the rosetta stone in contemporary neuroscience. Glial cells support CNS homeostasis through evolutionary conserved mechanisms. Upon damage, glial cells activate an immune and inflammatory response to clear the injury site from debris and proliferate to restore cell number. This glial regenerative response (GRR) is mediated by the neuropil-associated glia (NG) in Drosophila, equivalent to vertebrate astrocytes, oligodendrocytes (OL), and oligodendrocyte progenitor cells (OPCs). Here, we examine the contribution of NG lineages and the GRR in response to injury. The results indicate that NG exchanges identities between ensheathing glia (EG) and astrocyte-like glia (ALG). Additionally, we found that NG cells undergo transdifferentiation to yield neurons. Moreover, this transdifferentiation increases in injury conditions. Thus, these data demonstrate that glial cells are able to generate new neurons through direct transdifferentiation. The present work makes a fundamental contribution to the CNS regeneration field and describes a new physiological mechanism to generate new neurons.

Bidirectional causal relationships between the skin microbiome and psoriasis: Insights from Mendelian randomization analysis.

Psoriasis is a chronic inflammatory skin disease affecting 2% of the global population. Recent research suggests the skin microbiome plays a critical role in psoriasis. Skin microbiome data were obtained from the KORA FF4 study in Germany, and psoriasis data from FinnGen genome-wide association study summary statistics. Forward and reverse 2-sample Mendelian randomization (MR) analyses were conducted to assess causal relationships. Forward MR analysis identified several microbial features as risk factors for psoriasis, including the family Neisseriaceae in sebaceous skin (OR = 1.036, 95% CI: 1.010-1.062, P = .0054), ASV011 in dry skin (OR = 1.024, 95% CI: 1.000-1.048, P = .0490), and the order Clostridiales in moist skin (OR = 1.016, 95% CI: 1.000-1.032, P = .0449). Protective features included ASV016 (OR = 0.972, 95% CI: 0.949-0.994, P = .0136) and ASV053 (OR = 0.973, 95% CI: 0.954-0.992, P = .0054) in dry skin. Reverse MR analysis confirmed psoriasis as a significant risk factor for changes in the skin microbiome, with notable associations in the dry skin region for asv002 (OR = 1.266, 95% CI: 1.061-1.510, P = .027) and genus: Haemophilus (OR = 1.364, 95% CI: 1.065-1.746, P = .013). This study reveals bidirectional causal relationships between the skin microbiome and psoriasis, highlighting specific microbial features such as Neisseriaceae and Clostridiales as potential risk factors. Further research is needed to develop treatments that modulate the skin microbiome to improve psoriasis outcomes.

Herbal medicine as a potential treatment for non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health concern, affecting over one-quarter of the global population. It is closely associated with the prevalence of obesity and metabolic syndrome. Current treatment options for NAFLD are limited and often have side effects. Traditional Chinese medicine (TCM) offers a promising alternative with its holistic approach and use of multi-component herbal formulations. A recent study explored the potential of the TCM formula, "Fanlian Huazhuo Formula (FLHZF)", to alleviate high-fat diet-induced NAFLD by regulating autophagy and lipid synthesis signaling pathways. TCM has shown advantages in the prevention and treatment of NAFLD due to its efficacy and minimal side effects. However, the complex multicomponent and multitarget characteristics of formulas such as FLHZF present challenges in research. Future studies should focus on utilizing modern techniques to deepen our understanding of the mechanisms of action and active ingredients of Chinese herbal medicines, thereby promoting their modernization.

Rice Master Regulator 'HYR' Enhances Growth and Defense Mechanisms with Consequences for Fall Armyworm Growth and Host Selection.

Rice (Oryza sativa L.), the staple food for half of the world's population, suffers heavy damage by insect herbivores, especially the emerging Fall Armyworm (FAW), Spodoptera frugiperda. HYR (HIGHER YIELD RICE), a master regulator of multiple biological pathways with an established gene regulatory network, has been found to improve rice yield to ~29% and tolerance to environmental stress. However, its impact on defense has not been explored. We hypothesized that, FAW would target HYR plants because of its vigorous growth, and lead to trade offs for defense. Through a series of experiments with HYR and its wild type, we show that HYR plants have enhanced below-ground growth, physiological traits, direct and indirect defense traits including leaf trichomes, wax and volatile organic compounds. To test possible phytohormone mediated defense signalling, we focussed on jasmonic acid and salicylic acid gene expression panel and found most of these genes are highly expressed in HYR when compared to its wildtype counterpart. Bioassays examining developmental milestones also revealed that HYR plants effectively deter FAW, and when force fed, caused negative effects. Collectively, our findings suggest that the master regulator HYR (Higher Yield Rice expressing) plants enhance growth and physiological traits, as well as physical and chemical defense mechanisms through co-ordinated defense gene expression, that deter herbivore feeding, growth, development and host selection.

Evaluating the Role of Coenzyme Q10 in Migraine Therapy—A Narrative Review

Migraine, with a prevalence of 14–15% in the world population, is one of the diseases that markedly reduce patients’ quality of life. Despite extensive therapeutic tools, the search for substances that may have potential therapeutic properties in migraine patients is still ongoing. Coenzyme Q10 (CoQ10), as a natural and potent antioxidant, appears to be a valuable adjunct in treating and preventing many conditions, such as cardiovascular, metabolic, autoimmune, or neurodegenerative diseases. This review aims to evaluate if CoQ10 can be a potential therapeutic agent in the treatment of migraine. Based on the studies discussed, CoQ10 may have applications in migraine therapy due to its potent anti-inflammatory and oxidative stress-reducing properties. Furthermore, by improving mitochondrial function, CoQ10 can contribute to the energy supply to brain cells, which is particularly important in migraine. Supplementation with CoQ10 in a wide range of doses has resulted in many therapeutic benefits in subjects, including a decrease in the frequency and duration of migraine attacks, a reduction in nausea, a lower maximum pain during an attack, and fewer days with migraine. Therefore, it seems that CoQ10 may be a relevant therapeutic supplement for the treatment and prevention of migraine.

Effects of Cytoplasmic Sterility on Roots and Yield of Nitrogen Sources in Rice.

Rice is an important food crop, acting as the staple food for more than 50% of the global population. We selected seedlings (two sterile male lines: WA803A and JW803A) that had different cytoplasmic but the same nuclear composition and were heterogeneous. The maintainer line 803B was also used. We aimed to study their nitrogen uptake rate in different concentrations of NH4+ and NO3- and explore the differences in nitrogen uptake efficiency between different cytoplasmic genes. The results showed a significant difference in the nitrogen uptake rate for different seedlings. With ammonium nutrition, the nitrogen uptake efficiency of the JW cytoplasm was significantly higher than that of the WA cytoplasm. In low concentrations of ammonium nitrogen, the JW cytoplasm had an additive effect to the nuclear gene regulation of ammonium uptake. The JW cytoplasm's ammonium nitrogen absorption effect on nuclear gene regulation was higher than that of the WA cytoplasm. The effect of the WA and JW cytoplasms on the nitrate uptake rate was not significant, and the nuclear gene regulation of both cytoplasms was reduced by absorbing nitrate. Under nitrogen deficiency conditions, the material output and conversion rate of the JW-type cytoplasmic hybrid rice combination was relatively high, significantly higher than those of other cytoplasmic combinations. Under medium nitrogen conditions, the material output and conversion rate of the (N2) W-type hybrid rice combination were significantly higher than those of the other cytoplasmic combinations. The yield of JW-type rice first increased and then decreased with the increase in the nitrogen application rate and was highest, 8195.55 kg/hm2, under the N2 treatment.

Using Natural Language Processing Methods to Build the Hypersexuality in Bipolar Reddit Corpus: Infodemiology Study of Reddit.

Bipolar is a severe mental health condition affecting at least 2% of the global population, with clinical observations suggesting that individuals experiencing elevated mood states, such as mania or hypomania, may have an increased propensity for engaging in risk-taking behaviors, including hypersexuality. Hypersexuality has historically been stigmatized in society and in health care provision, which makes it more difficult for service users to talk about their behaviors. There is a need for greater understanding of hypersexuality to develop better evidence-based treatment, support, and training for health professionals. This study aimed to develop and assess effective methodologies for identifying posts on Reddit related to hypersexuality posted by people with a self-reported bipolar diagnosis. Using natural language processing techniques, this research presents a specialized dataset, the Talking About Bipolar on Reddit Corpus (TABoRC). We used various computational tools to filter and categorize posts that mentioned hypersexuality, forming the Hypersexuality in Bipolar Reddit Corpus (HiB-RC). This paper introduces a novel methodology for detecting hypersexuality-related conversations on Reddit and offers both methodological insights and preliminary findings, laying the groundwork for further research in this emerging field. A toolbox of computational linguistic methods was used to create the corpora and infer demographic variables for the Redditors in the dataset. The key psychological domains in the corpus were measured using Linguistic Inquiry and Word Count, and a topic model was built using BERTopic to identify salient language clusters. This paper also discusses ethical considerations associated with this type of analysis. The TABoRC is a corpus of 6,679,485 posts from 5177 Redditors, and the HiB-RC is a corpus totaling 2146 posts from 816 Redditors. The results demonstrate that, between 2012 and 2021, there was a 91.65% average yearly increase in posts in the HiB-RC (SD 119.6%) compared to 48.14% in the TABoRC (SD 51.2%) and an 86.97% average yearly increase in users (SD 93.8%) compared to 27.17% in the TABoRC (SD 38.7%). These statistics suggest that there was an increase in posting activity related to hypersexuality that exceeded the increase in general Reddit use over the same period. Several key psychological domains were identified as significant in the HiB-RC (P<.001), including more negative tone, more discussion of sex, and less discussion of wellness compared to the TABoRC. Finally, BERTopic was used to identify 9 key topics from the dataset. Hypersexuality is an important symptom that is discussed by people with bipolar on Reddit and needs to be systematically recognized as a symptom of this illness. This research demonstrates the utility of a computational linguistic framework and offers a high-level overview of hypersexuality in bipolar, providing empirical evidence that paves the way for a deeper understanding of hypersexuality from a lived experience perspective.

Postharvest Processing of Millets: Advancements &amp; Entrepreneurship Development Opportunities

ABSTRACTMillets, a member of the Poaceae family, are renowned for their significant nutritional value. In light of the increasing concerns surrounding climate change, millets offer a promising solution for the global population due to their exceptional ability to tolerate various abiotic stresses, such as drought, salinity, light, and heat. Additionally, millets have short growing periods and can thrive in adverse weather conditions with minimal irrigation requirements. It is essential to process millets before consuming them to extend their shelf life and improve their nutritional and sensory characteristics. The postharvest processing of millets encompasses both primary and secondary processing operations. However, the need for appropriate processing machinery and the short shelf life of millet flour caused by high lipid levels and enzymatic activity pose significant challenges in millet processing. These limitations can be addressed by employing suitable processing methods. Furthermore, there is ample opportunity for entrepreneurship in millet processing and value addition. Potential areas for exploration include the development of value‐added processing technologies, diversification of processing technologies, and expansion of machinery for commercial production in food markets. This article provides insights into advancements in millet processing and entrepreneurial technologies.

Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses.

As global population ages, maintaining cognitive health in elderly is crucial. Previous studies suggest a positive link between healthy aging and cognition, but the neural mechanisms remain unclear. This study used genome-wide association studydata to investigate neural mechanisms between healthy aging and cognition. We employed 2-sample Mendelian randomization to evaluate causal relationship between healthy aging (indexed by a multivariate genetic predictor, mvAge) and 6 cognitive measurements. We then used a 2-step Mendelian randomization approach and mediation analysis to identify brain imaging-derived phenotypes potentially mediating this relationship. Mendelian randomization analysis indicated that healthy aging had a positive causal relationship with various cognitive functions (common executive function, intelligence, cognitive performance, and fluid intelligence score). Two-step Mendelian randomization analysis identified 27 brain imaging-derived phenotypes having robust causal relationships with healthy aging and various cognitive measurements. Mediation analysis suggested that volume of subcallosal cortex might mediate effects of healthy aging on all 4 cognitive functions. Volume of cerebellum's VIIb could mediate effects on common executive functions, while fractional anisotropy in the anterior thalamic radiation might mediate effects on intelligence and cognitive performance. These findings suggest that specific brain regions may play a potential mediating role in the relationship between healthy aging and cognitive maintenance.

On-Farm Research in integrated farming systems: Addressing challenges of small farms at the field level

The ever increasing global population has intensified the pressure on agriculture, driving a shift toward smallholder farming systems. Historically, agricultural technologies have primarily catered to large, mechanized farms, exacerbating the disparity between large and small landholders. While strides have been made in achieving food security, livelihood security for farmers remains elusive, especially for smallholders and marginal farmers, who constitute over 80% of the global farming population. In India, these farmers account for nearly one-fourth of the world's small and marginal farms, cultivating less than 2 ha of land. Raising the income of these smallholders poses a significant challenge to researchers, policymakers, and governments. Given the constancy of land resources, horizontal intensification is not possible. The solution lies in vertical intensification through diversification, exemplified by the Integrated Farming System (IFS). IFS integrates various farming enterprises, allowing the by-products of one enterprise to serve as inputs for another, enabling resource recycling, efficient use of labour and space, and reduced market dependency. However, implementing on-station IFS models directly at farmers' fields is impractical due to high initial costs. Interventions targeting critical inputs within existing farming systems, as demonstrated by the All India Coordinated Research Project on Integrated Farming Systems–On-Farm Research (AICRP-Integrated-IFS-OFR), offer a promising alternative. By investing just ₹7,889 this approach achieved an 86% increase in net income within two years of implementation (2022–24), showcasing its potential to improve the livelihoods of small and marginal farmers effectively.

Research progress on small extracellular vesicles in diabetic nephropathy.

Virtually all cell types are capable of secreting small extracellular vesicles (sEV), which can be internalized by recipient cells, thereby serving as vehicles for intercellular communication. The cargoes of these vesicles, such as microRNAs, circular RNAs, proteins, and lipids, play significant roles in both normal cellular functions and the pathogenesis of various diseases. Diabetic Nephropathy (DN), a complication arising from diabetes, is expected to contribute to a 54% increase in the global diabetic population between 2015 and 2030, leading to substantial economic burdens on individuals and healthcare systems. sEVs, as promising biomarkers, demonstrate diverse mechanistic responses in different types of Diabetic Kidney Disease (DKD). They also hold advantages in the early prediction of renal damage. This article reviews the functional mechanisms of sEVs in DKD and their potential as therapeutic targets and biomarkers.

Multifaceted Role of Veterinarians in Mitigating Zoonotic Diseases, Sustainable Livestock Production and One Health Integration

Food security is a broad term; however, a brief definition of food security is the continuous accessibility of adequate safe and nutritious food to swelling population of the world produced under sustainable, equitable and competitive conditions so that, consumers can enjoy a healthy and productive life. Food security has become an inevitable challenge due to population growth over the last few centuries and the change in food preferences of consumers worldwide. The significance of this matter is evident from the fact that it is directly or indirectly a part of UN SGDs and is one of the burning topics recognized by one health approach. Livestock-based food products are essential in ensuring food availability, one of the 4 As of food security. Veterinarians have a crucial role to play in this regard as they are directly linked with the production, processing and marketing of livestock-based products. Additionally, they play a pivotal role in controlling zoonotic food-borne diseases and combating other livestock-associated diseases. Therefore, they should be part of policy-making organizations to overcome the challenge of food insecurity. This paper discusses food security, its public health impact, growing population, food consumption trends and the role played by the livestock in meeting this concern. This paper also discusses food-borne zoonotic diseases and their effects on food safety. Lastly, it stresses the multifaceted role of veterinarians in confronting food insecurity.

Resistome and virulome determination in Helicobacter pylori using next-generation sequencing with target-enrichment technology.

The identification of Helicobacter pylori infection from gastric biopsy samples requires PCR or bacterial cultures. However, it is difficult to culture H. pylori because it is a fragile bacterium. Next-generation sequencing (NGS) allows direct assessment of the resistome and virulome. Here we describe a new NGS method for studying the resistome and virulome of H. pylori directly from gastric biopsies, based on enrichment analyses and targeted sequencing of H. pylori DNA. In all, 19 DNA samples from human gastric biopsies that tested positive for H. pylori were analyzed. The Agilent SureSelectXT target-enrichment protocol was used with a custom bait library prior to sequencing using the Agilent MagnisDx NGS Library Prep System. NGS sequencing was performed on the Illumina iSeq 100 sequencer using RNA probes for virulence, resistance, and molecular typing genes. The method yielded significant results with a limit of detection of around 1.8e5 CFU per mL H. pylori. Mutations in the 23S rDNA sequence associated with macrolide resistance and in the quinolone resistance-determining region of gyrase A associated with levofloxacin resistance were correctly identified. The results of MLST phylogeny analyses performed after target-enrichment were consistent with those obtained via conventional Sanger sequencing. Among the cagA-positive isolates, the gene was detected correctly, and the vacA genotype was determined. In conclusion, our enrichment method enables rapid assessment of the resistome and virulome of H. pylori directly from fresh gastric biopsies.IMPORTANCEHelicobacter pylori, a bacterium that infects at least 50% of the world population, is often treated by probabilistic antimicrobial therapies due to the lack of antimicrobial resistance data provided by clinical laboratories to clinicians. However, targeted antimicrobial therapies are increasingly recommended to achieve efficient eradication with a limited impact on the gut microbiota and with fewer adverse events for the patient. Recent advancements in next-generation sequencing strategies have opened new opportunities in the diagnosis of H. pylori infection. The significance of our research is the development of a novel next-generation sequencing strategy based on target-enrichment. This approach enables the identification of the resistome and the virulome of H. pylori directly from gastric biopsies, providing clinicians with a broad overview of therapeutic options.

Investigation of the relationship between helicobacter pylori positivity and colon polyps in simultaneous oesophagogastroduodenoscopy and colonoscopy procedures.

Colorectal polyps evolve into colorectal cancer with genetic mutations. Helicobacter pylori (HP) infection, which is classified as carcinogen, is thought to affect 50% of the world population. Retrospectively, demographic data, HP positivity status, the size, location and number of polyps in patients over 18 years of age who underwent simultaneous sedated oesophagogastroduodenoscopy and colonoscopy procedures between January 2023 and December 2023 were analysed and documented through file records. One hundred and sixteen patients with polyps in the colon and who underwent polypectomy were analysed. HP histology was positive in 50% of cases with colon polyps. No difference was observed in age, gender, number of polyps, polyp size, polyp type and polyp localisation between patients with HP and patients without HP. Colon polyps in patients with tubular adenoma were more common in the transverse colon (P = 0.035). However, no difference was observed regarding HP histology. In patients with hyperplastic polyps, the proportion of patients with a polyp size above 1 cm was higher and those with a polyp size below 0.5 cm was lower (P = 0.029). However, no difference was observed regarding polyp localisation and HP. Although HP may be effective on colon polyps due to its effect on virulence factors and gastrointestinal hormones, current literature cannot clearly address this question and the relationship between HP histology and colon polyps is still controversial. In the present study, no significant results were found between demographic data and subtypes of polyps.

Estimation of Working Error of Electricity Meter Using Artificial Neural Network (ANN)

Together with the rapidly growing world population and increasing usage of electrical equipment, the demand for electrical energy has continuously increased the demand for electrical energy. For this reason, especially considering the increasing inflation rates around the world, using an electricity energy meter, which works with the least operating error, has great economic importance. In this study, an artificial neural network (ANN)-based prediction methodology is presented to estimate an active electricity meter’s combined maximum error rate by using variable factors such as current, voltage, temperature, and power factor that affect the maximum permissible error. The estimation results obtained with the developed ANN model are evaluated statistically, and then the suitability and accuracy of the presented approach are tested. At the end of this research, it is understood that the obtained results can be used by high accuracy rate to estimate the combined maximum working error of an active electricity energy meter with the help of a suitable ANN model based on the internal variable factors.

The Molecular Mechanisms of Natural Medicinal Active Ingredients Interfering with Male Fertility.

The challenges posed by excessive global population growth remain significant. Hormonal female contraceptive pills, which have been approved for over 60 years, serve as an important means of contraception; however, many women experience adverse effects after taking these pills, including abnormalities in blood clotting, dizziness, headaches, and vomiting. In this context, male contraceptives have emerged as a prominent area of research. Unfortunately, most male contraceptives are still in the experimental or clinical research stages. Therefore, screening for active ingredients that can specifically inhibit sperm function from natural drug active ingredient libraries holds substantial clinical and practical significance. In this manuscript, we review the inhibitory effects of various natural drug active monomers on sperm function and their underlying molecular mechanisms, aiming to provide theoretical insights for the future development of novel male contraceptives.

Pathogenic variants in the Alport genes are prevalent in the Singapore multiethnic population with highest frequency in the Chinese

Alport syndrome is a common monogenic kidney disease resulting from pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The estimated global population prevalence is one in 106 individuals for autosomal dominant (AD) and one in 2,320 for sex-linked (XL) conditions. Here, we aimed to estimate the population prevalence of individuals carrying pathogenic variants that cause Alport syndrome in Singapore, and to stratify the prevalence by ancestry. We used population-scale genomic data of 9,051 unrelated subjects, comprising 5,443 (60.8%) Chinese, 1,922 (21.4%) Indian and 1,686 (17.8%) Malay individuals. The prevalence of individuals with pathogenic variants that cause AD and XL Alport syndrome are 1 in 165 and 1 in 2,262 respectively. Additionally, 0.8% of Chinese and 0.3% of Malay populations carry pathogenic Alport syndrome variants, with Chinese individuals being 2.7 times more affected than Malays (95% CI:1.147–6.437, P = 0.027). Interestingly, each pathogenic variant was associated with people of a single ancestry. The two most prevalent pathogenic variants, COL4A3: c.3856G > A (p.Gly1286Arg) (n = 8) and COL4A3: c.4793T > G (p.Leu1598Arg) (n = 4), were exclusively found in the Chinese population. In conclusion, AD Alport syndrome may be prevalent in Singapore, with higher frequencies among the Chinese. Furthermore, founder effects may exist within the ancestries.