To predict extreme weather events, we conducted high-resolution global atmosphere modeling and simulation using high-performance computing. Using a new-generation global weather/climate prediction model called MPAS (Model for Prediction Across Scales) with variable resolution, we tested strong scalability on the KISTI (Korea Institute of Science and Technology Information) supercomputer NURION. In addition to assessing computational performance, we simulated three typhoons that occurred in 2019 to analyze the forecast accuracy of MPAS. MPAS results were also applied to force an ADCIRC (The Advanced CIRCulation) + SWAN (Simulating Waves Nearshore) model to predict coastal flooding over southern Korea. The time-integration of MPAS showed excellent scalability up to 4096 cores of NURION KNL (KNight Landing) nodes, but a serious I/O bottleneck issue was still found after trying two additional I/O strategies (i.e., adjusting the stripe count and using a burst buffer). On the other hand, the forecast accuracy of MPAS showed very encouraging results for wind and pressure during typhoons. ADCIRC+SWAN also generated a good estimate of significant wave height for typhoon Mitag. The proposed variable-resolution MPAS model, under an efficient computational environment, could be utilized to predict and understand the highly nonlinear chaotic atmosphere and coastal flooding in typhoons.