Development Of Global Strategy Research Articles

Asia-inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler.

With the International Conference on Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) E17 guidelines in effect from 2018, the design of Asia-inclusive multiregional clinical trials (MRCTs) has been streamlined, thereby enabling efficient simultaneous global development. Furthermore, with the recent regulatory reforms in China and its drug administration joining the ICH as a full regulatory member, early participation of China in the global clinical development of novel investigational drugs is now feasible. This would also allow for inclusion of the region in the geographic footprint of pivotal MRCTs leveraging principles of the ICH E5 and E17. Herein, we describe recent case examples of model-informed Asia-inclusive global clinical development in the EMD Serono portfolio, as applied to the ataxia telangiectasia and Rad3-related inhibitors, tuvusertib and berzosertib (oncology), the toll-like receptor 7/8 antagonist, enpatoran (autoimmune diseases), the mesenchymal-epithelial transition factor inhibitor tepotinib (oncology), and the antimetabolite cladribine (neuroimmunological disease). Through these case studies, we illustrate pragmatic approaches to ethnic sensitivity assessments and the application of a model-informed drug development toolkit including population pharmacokinetic/pharmacodynamic modeling and pharmacometric disease progression modeling and simulation to enable early conduct of Asia-inclusive MRCTs. These examples demonstrate the value of a Totality of Evidence approach where every patient's data matter for de-risking ethnic sensitivity to inter-population variations in drug- and disease-related intrinsic and extrinsic factors, enabling inclusive global development strategies and timely evidence generation for characterizing benefit/risk of the proposed dosage in Asian populations.

Self-assembled Si-based anode combined with electrostatic spinning method to realize high-performance lithium-ion batteries

Addressing the volume expansion when silicon and metal oxides alone are used as anode materials for lithium-ion batteries. This study used a simple self-assembly method and electrostatic spinning technique to prepare silicon@copper oxide@carbon nanofibres (CNFs) anodes with dual modification. The high rigidity of metal oxide CuO and the excellent cycling stability of CNFs effectively reduce the buildup of silicon particles, alleviate the volume expansion effect, and improve the electrical conductivity, which leads to better cycling stability and larger specific capacity of lithium-ion batteries. An excellent reversible specific capacity of 748.5 mAh g‐1−1 was observed after 800 cycles at a high current density of 1 A g−1. In addition, the surface of Si@CuO@CNFs electrodes remains smooth and undamaged after 800 cycles, and the increase in cross-sectional thickness is about 68 %, which is significantly smaller than the 300 % increase in cross-sectional thickness of pure Si anode and effectively improves the specific capacity of Li-ion batteries. This research optimizes the design of silicon-based anode materials with simple and mature process technology, which makes an indispensable contribution to developing high-efficiency, long-life, and environmentally friendly lithium-ion batteries. The easy availability and non-polluting nature of the materials used also effectively reduce the reliance on rare or expensive elements, minimize the production process's environmental impact, and vigorously promote the global energy transition and low-carbon green development strategy.

Fundamentals of building a global development strategy and improving competitiveness of the Russian military-industrial complex

Fundamentals of building a global development strategy and improving competitiveness of the Russian military-industrial complex

Theoretical Justification for the Implementation of Special Economic Zones: The Case of Luanda-Bengo Economic Zone in Angola

Purpose: In the present study, a literature review was carried out on theories of regional development, namely: the classic ones, those with an emphasis on agglomeration factors, and new theories of regional development. It intended to provide a theoretical foundation for implementing special economic zones, contextualizing the analysis to the Luanda-Bengo Special Economic Zone. Materials and Methods: Thus, the document analysis technique was used to review relevant literature on regional development and its main supporting theories. Findings: It was possible to achieve three main results: that the existence of hubs that bring together population and capital play a central role in the location of commercial and industrial activities; that companies come together in a logic of cooperation, innovation competitiveness, and ZEELB, as a hub of industrial activity, is no exception. Finally, the factors that determine the location and spatial agglomeration of economic activities, as well as the relationships of interdependence established between the various driving and driven units, possible in a ZEE, are also present in the foundations of adopting ZEELB operations. Implications to Theory, Practice and Policy: Theories about the location and agglomeration of economic activities in geographically, customs, and legally demarcated spaces, such as ZEELB, should be used in studies for future implementations of similar projects. Exchange between academia and structuring investment planning bodies such as ZEELB, so that based on its adoption as part of the global economic development strategy, is necessary. Public policymakers should see ZEELB as an opportunity to serve as a laboratory for policies at the following levels: tax, customs, regulatory, commercial, and management

Artificial Intelligence and Renewable Energy Utilization

Abstract This article shows the role that digital intelligence has on renewable energy, based on literature underpinnings. Therefore, the methodological research is based on literature review to demonstrate the link between artificial intelligence and renewable energy, with a focus on global sustainable development strategies in this field. The main findings reveal the fact that we must take advantage of the opportunities offered by artificial intelligence on energy, in general, and renewable energy, in particular. Referring to literature, it is constantly expanding due to the importance of the development of renewable energy for researchers but also for the population, being many parties interested in this field. The aim of the study is to highlight the relationship between renewable energy and artificial intelligence. Therefore, with the help of artificial intelligence and energy innovations, the population enjoys renewable energy that exists in its many forms (solar panels or photovoltaic panels, water, or wind energy and so on). To put in a nutshell, the research considered in this article reflects the impact of artificial intelligence on renewable energy as part of supporting the achievement of sustainable economic development.

FEATURES OF THE BACHELOR’S EDUCATIONAL PROGRAM “POLISH STUDIES – LANGUAGE, CULTURE, SOCIETY” AT THE JAGELLONIAN UNIVERSITY (for Chinese Students)

The article examines the special 2-year double degree diploma program of the Bachelor’s Education Level “Polish studies – language, culture, society” for Chinese students at the Institute of Polish Glottodidactics of the Jagiellonian University. This is an innovative project, the idea of which appeared back in 2006, when a cooperation agreement was signed between the Jagiellonian University and the Chinese State Administration for the Development of the Chinese Language, but the idea was implemented in 2019–2020. The turning point in this direction was 2013, when the government of the People’s Republic of China adopted the initiative of the One Belt, One Road global infrastructure development strategy, which led to a number of reforms not only in the economic, but also in the educational sphere, in particular in the teaching of Polish as a foreign language. Poland became an important point in the development of the implementation of the idea of this global project as a transfer between Western Europe and China. In accordance with the signed agreement and the Common European Framework of Reference for Languages in Poland Chinese students deepen their knowledge of the Polish language, history and culture and acquire new skills and abilities. This program is implemented in two main parts (2 + 2). The first four semesters take place at the student’s home university in China, and the next four semesters are at the Jagiellonian University. The main task of this program is to train specialists who, on the one hand, have a high level of language skills, but, on the other hand, they must also have knowledge of the country whose language they are studying, have a broad global perspective and be able to participate in a strong competition and international cooperation. Also, the article pays special attention to the prerequisites for the creation of the program “Polish studies – language, culture, society”, describes the main tasks and academic disciplines, the topics of diploma theses, and also explains the mechanisms of using the experience of Polish colleagues on the Ukrainian reality. Key words: Double Degree Program, Polish Studies, Chinese students, Institute of Polish Glottodidactics, Jagiellonian University.

How do Financial Development and Stability Shape Human Development?

Abstract The crucial role of financial systems in sustainable development has become the center of global and national interest and development strategies, and more developed and stable financial systems are the cornerstone for development finance and achieving the sustainable development goals. This research aims to examine the impact of financial development and stability on human development firstly in a sample of 185 countries worldwide, and secondly in a sample of 21 MENA countries, over the period 1990–2019. This study adopts the Panel Data Econometrics (Fixed Effects and Random Effects Methods) and proxy for human development by exploiting the UNDP’s Human Development Index and its three subindices (Education, Income, and Life expectancy), while it adopts broad money, credit to the domestic private sector, and banking sector deposits (all as a percentage of GDP) to proxy for financial development. Moreover, it represents financial stability by the banking sector Z-score and a dummy variable representing crises. The empirical results reveal the prevailing role of development and stability in the financial systems on human development and its three subcomponents, regardless of the country’s economic development level.

Optimized low carbon scheduling strategy of integrated energy sources considering load aggregators

In the context of the global low-carbon energy development strategy, the massive influx of renewable energy leads to the instability of the power system, so it is necessary to carry out effective scheduling strategy and management mechanism for energy. On this basis, the Integrated Energy System including Electricity/Heat/Storage (EHSIES) is discussed in this paper. First, an ordered clustering method using a combination of simulated annealing and improved profile coefficients for load evolution number approximation is proposed. Second, a hybrid load clustering algorithm based on hierarchical clustering algorithm and K-means++ is presented and four types of load scenarios are obtained. Third, an Improved Harris Hawk Optimization (IHHO) algorithm based on the hybrid strategy is proposed and solved to the model of EHSIES. Finally, under the premise of the dynamic carbon trading mechanism considering historical compliance and load aggregator management, the scheduling strategies of flexible electric loads and thermal loads participating in EHSIES are discussed and solved by CPLEX. The results show that the solution time of IHHO is 50% and 33.3% lower than that of particle swarm optimization (PSO) and Harris hawk optimization (HHO), and the number of iterations is 76.6% and 56.25% lower than that of PSO and HHO, respectively. In addition, considering a flexible load aggregator and a compliance-based dynamic carbon trading mechanism in EHSIES scheduling can effectively reduce the actual operating cost by 27.37%, the source-side energy spill rate by 68.75%, and the carbon emission by 51.92% and improve the operating efficiency and economic benefits of EHSIES.

An Introduction to a Way of Increasing Chinese International Influence: The Implementation of the Belt and Road Initiative (BRI)

This article is written for a general audience of economists, including those who have a novice understanding of this subject. China continues to become more important in the community of nations. In order\to promote further internationalization of China’s influence, major strategies are being pursued. The focus of this article is the implementation of the ambitious program of the Belt Road Initiative (BRI). Within China, this program is called One Belt One Road (Chinese: 一带一路; pinyin: Yīdài Yīlù) or OBOR for short. This is a global infrastructure development strategy adopted by the Chinese government in 2013 to invest in more than 150 countries and international organizations (World Bank, 2019). This article states that China benefits from the BRI and it was found that lower- and middle-income countries are more inclined to join the BRI, in comparison to high income countries This tendency is not 100 percent true. Simultaneously, there is the effort to increase the use of Chinese Renminbi (RMB) in transactions between all nations. (Chinese yuan is another phrase for RMB.) The Chinese RMB already has attained the status of reserve currency (Gentle, 2016). Of course, there is a lot of synergy between the implementation of the BRI and other means for increasing the international presence of China. This article asks the research question of does the BRI increase China’s international presence in the BRI? The answer is yes, considering the many countries, organizations and projects involved in the BRI. Tables in this article convey this information. This article may serve as a broad introduction to the BRI. The reader can thus move on to explore what other researchers have done on this issue.

A roadmap to SDGs-emergence of technological innovation and infrastructure development for social progress and mobility

The goal of this study was to conduct a thorough investigation on understanding how infrastructure growth and technological innovation affect social mobility and the Sustainable Development Goals (SDGs). This study aimed to illuminate the underlying mechanisms by exploring the mediating function of psychological empowerment and the moderating impact of community satisfaction. The study carefully chose a sizeable sample of 370 connected to the mega project CPEC. Data collection was carried out using a questionnaire-based approach. Notably, the study confirmed the large and favorable influence of technical innovation and infrastructural development on both the SDGs-13 (climate change) and social mobility. Furthermore, this study provided light on the critical function of environmental impacts identifying it as an important mediating mechanism that magnifies the effects of innovation and infrastructure on long-term development outcomes. It gives decision-makers in government, business, international organizations, and local communities useful information by offering empirical data and insights. This study offers a novel perspective and explores the relationship between infrastructure growth, technological innovation, social mobility, and SDGs-13-climate change. It uncovers the pivotal roles of psychological empowerment and community satisfaction, offering fresh insights into global development strategies influencing SDGs.

Comprehensive Analysis of DC/DC Converters for Electric Vehicles Applications: Topologies and Future Perspectives

In order to implement the global sustainable development strategy, reduce the burden of traditional fuel vehicles on the environment, and at the same time, due to the increasing oil prices, more and more people are reluctant to use fuel vehicles, the global automobile industry. The centre of gravity has gradually shifted from traditional industrial energy vehicles to electric vehicles. As an integral part of the electric vehicle powertrain, the DC/DC converter has the important function of supplying power to the power steering system, air conditioning and other auxiliary equipment.This paper describes in detail the DC/DC converters that provide power for electric vehicles, describes in detail the different types of DC/DC converters as well as the different topologies, and analyses the characteristics of each topology and the method of providing power to the circuit by drawing the circuit of the different topologies. Next, the advantages and disadvantages of various topologies are compared, and improvement methods and future prospects are proposed for the shortcomings of different topologies.

The Developing Global Employability Competencies of Indonesian Seafarers for Enhanced End-User Acceptance through Brand Experiences

The growth of global demand for qualified Indonesian seafarer labor is a key issue in this study. This study aims to analyze the impact of global work competencies and the mediating role of sensory, behavioral, and intellectual experiences in accepting end users in crew management companies. The study involved 240 crew managers/supervisors who interacted with Indonesian seafarers. The analysis was carried out using the Partial Least Square-Structural Equation Method. Research findings show that global work competencies have a significant effect on end-user acceptance. Nonetheless, sensory experience does not mediate the relationship between global work competence and end-user acceptance. In contrast, behavioral and intellectual experience play a key role as mediators, with intellectual experience having a more prominent impact than behavioral experience in increasing end-user acceptance. The conclusion of this study emphasizes the importance of global work competence and intellectual experience in increasing end-user acceptance in the context of crew management. The implications of this research support the development of global work competency development strategies to improve service quality in the shipping industry.

The Hubs of Transformation Dictated by the Innovation Wave: Boston as a Case Study

Cities have become nodes of global networks, standing at the intersection points of the flows of capital, goods, workers, businesses, and travelers, making them spots where innovation, progress and economic development occur. Design emerges as an essential feature in this process, which this manuscript defines as the ‘laboratorization of cities’, a cutting-edge urban development paradigm that emphasizes cities as dynamic laboratories for innovation and experimentation. This study explored the spatial hubs of transformation within the knowledge economy, providing an overview of the current models of innovation spaces before focusing on the innovation district of one of the cities that are riding the innovation wave, namely Boston, USA. Information was gathered from observations, exploratory interviews with key stakeholders, and on-desk data. The study has significant implications, spanning from informing global urban development strategies to impacting regional economic planning and national policies. It provides valuable insights into how design, innovation, and urban development are interconnected, potentially reshaping how cities and regions approach their growth in the current knowledge-driven era. Useful lessons can be drawn from the case study analysis, allowing to define valuable tools for policymakers, a forward-looking perspective on the future of the laboratorization of cities and the evolving role of design, providing a roadmap for cities aiming to position themselves as global innovation hubs.

Global Diversity Character Development Strategy at the Center for Indonesian Citizenship Education Klang Malaysia

The issue of global diversity is an interesting one and must be introduced to native Indonesian students studying in Malaysia, one of whom is the Klang Malaysia Indonesian Citizen Education Center (PPWNI). The last study showed that seventh-grade students at PPWNI Klang, Malaysia, did not yet understand the meaning of global diversity. This study aims to describe the strategies of school principals and teachers to shape the character of global diversity in citizenship education and find out what diversity values are implemented in students. The research method used is descriptive-qualitative, with data collection through observation, interviews, and documentation. The analysis of research on students at the Indonesian Citizenship Education Center (PPWNI) in Klang, Malaysia, shows that the level of understanding of students still does not understand the meaning of global diversity. The activities carried out by school principals, teachers, and researchers in developing an attitude of global diversity in students by doing habituation at school, such as providing reading material on multicultural education, providing an understanding through Pancasila Education and Citizenship, and providing an understanding of global diversity through the media of global diversity posters. The implications of this research can make it easier for students to learn and understand individual differences and develop a tolerant attitude towards different people. Some of the results of the above activities that are most effective in providing students with an understanding of global diversity are achieved by using poster media, which can facilitate students' understanding of learning about differences and developing an attitude of empathy towards different people.

The Influence of Changing Socioeconomic Conditions in Europe on the Prioritisation of Risks in Travel Behaviour: A Case Study

Pandemics, political instability, social conflict and unrest, the economic crisis resulting from changes in energy supply contracts, terrorism, and civil and international wars exert a negative impact on the lives of millions of people. These events undermine economic and social stability, and they affect travel behaviour (TB). Understanding preferences in travel behaviour is essential for designing effective and sustainable transport systems. Agenda 2030 (the global sustainable development strategy) assigns a central role to mobility and transport in sustainable development and its components: economic, social, and environmental. Relevant research is scarce, which is why potential threats, including changes in socioeconomic factors that affect TB in functional urban areas (FUAs), should be identified and prioritised. The main aim of this study was to determine changes in the prioritisation of threats to TB resulting from the socioeconomic consequences of the COVID-19 pandemic and the energy crisis in Europe. The study involved an analysis of the literature, a comprehensive classification of potential threats that could impact TB, as well as an expert survey. The results of these analyses were used to develop a list of 46 factors that were grouped into six categories of key threats: social, economic, legal, infrastructural, technological/SMART, and environmental. The level of significance, similarities, and differences in the prioritisation of threats during the COVID-19 pandemic and the energy crisis after the outbreak of the military conflict in Ukraine (duration and range) were compared across 22 European countries.

THE IMPACT OF FINANCIAL DEVELOPMENT AND STABILITY ON HUMAN DEVELOPMENT

The role of financial systems in sustainable development has become the center of global and national interest and development strategies, and more developed and stable financial systems are the cornerstones for development finance and for achieving the Sustainable Development Goals. This research aims at examining the impact of financial development and stability on human development in a sample of 185 countries over the period 1990–2019. This study adopts as the primary empirical methodology, the Panel Data Econometrics (Fixed Effects and Random Effects Methods), and for the robustness test, a Dynamic GMM system. To proxy for human development, it exploits the UNDP’s Human Development Index and its three sub-indices (Education, Income, and Life expectancy), while it adopts broad money, credit to the domestic private sector, and banking sector deposits (all as a percentage of GDP) to proxy for financial development. Moreover, it represents financial stability by the banking sector Z-score and a dummy variable representing crises. The empirical results reveal the prevailing role of development and stability in the financial systems on human development and its three sub-components, regardless of the country’s economic development level.

A Review on the Position of South Caucasus in China’s Belt and Road Initiative

On the “Belt and Road Initiative (B&R)” (Chinese: 一带一路), which is recognized as a global infrastructure development strategy by the People’s Republic of China, for the first time in his speech in Kazakhstan on 7 September 2013, Chinese President, Xi Jinping, spoke about the ancient ‘silk road’ and mentioned the establishment of the ‘Silk Road Economy Belt’. As of June 23, 2021, China had signed 206 cooperation documents which covered communications infrastructure, interconnection, investment, trade, finance, technology, people’s livelihoods, and oceans with 140 countries and 32 international organizations to join the “Belt and Road Initiative”. In 2020 alone, Chinese investors made direct investments of US$ 18.61 billion in 58 countries along the “Belt and Road Initiative” route. In China’s “Belt and Road Initiative”, the South Caucasus region, known as the middle corridor, is of great significance in the process of transition to Europe. Although Azerbaijan, Armenia and Georgia officially supported this Chinese initiative, the conflict, instability and changing geopolitics in the South Caucasus region made investors uneasy. In this study, global factors, the future of the “Belt and Road Initiative” in the region and the position of the South Caucasus were studied. And, the advantages and disadvantages of the initiative are evaluated.

Digital Access Opportunities for Women’s Empowerment Collectives: A Theory of Change Based on Social Capital

The social and economic empowerment of women using digital technology is critical to global development. This article presents an expanded theory of change to explain how digital technology could augment pathways to women’s empowerment in self-help groups (SHGs), developed through an application of social capital theories to two existing theories of change. Drawing on the analysis of secondary data, it discusses SHGs in India, the determinants of mobile phone use among women in India, particularly patriarchal gender norms, and select theories of change for women’s empowerment in SHGs. The proposed enhanced theory of change has the potential to assist implementers, policymakers, researchers and SHGs themselves to more effectively leverage the empowering potential of digital technology to improve the economic and social opportunities for women in the context of global development strategies.

Research on Strategies to Enhance the International Communication of Chinese Culture ——Taking Advertisement Translation as an Example

Driven by global development strategies, both domestic and foreign enterprises tend to utilize international brand advertisements to enhance their visibility and expand their global businesses. Since its accession to the WTO, China has experienced rapid development. Therefore, for Chinese enterprises, the appropriate translation of their product advertisements directly impacts commodity sales and consumer’s brand awareness. Building upon intercultural communication theory, this thesis will further analyze the challenges in intercultural communication as perceived by professional translators and explore their specific solutions through a case study. Subsequently, this essay will provide comprehensive insights into strategies and techniques for translating contemporary Chinese local brand advertisements in the context of intercultural communication.

Integrating multi-influencing factor techniques and fuzzy methods to identify recommendation domains for out-scaling conservation agriculture in China

Climate-smart agriculture (CSA) is a global development strategy aimed to address the interlinked challenges of food security and climate change. Expanding the implementation of conservation agriculture (CA), a vital component of CSA, is essential for enhancing agricultural and food security resilience while sustainably managing arable land. However, the extensive heterogeneity of biophysical and socioeconomic conditions presents significant complexities in promoting CA adoption. Addressing these challenges, this study carried out a comprehensive theoretical investigation of biophysical and socioeconomic factors influencing CA adoption and performance, integrating stakeholder feedback to create a systematic and robust evaluation index system for assessing CA suitability. By integrating multi-influencing factor techniques and fuzzy logic methods, we spatially identified suitable areas for CA implementation in China, providing valuable insights for land use policy. The reliability of the models was verified through a sensitivity analysis using the map removal sensitivity analysis method and the extended Fourier amplitude sensitivity test. The results indicated that 29.78% of the cultivated land was unsuitable or marginally suitable for CA, while 29.30 and 40.92% were determined to be moderately suitable and suitable zones, respectively. Suitable cultivated land was primarily distributed in the northern arid and semi-arid regions, the Loess Plateau, the Huang-Huai-Hai Plain, and the Northeast China Plain. Conversely, unsuitable, and marginally suitable cultivated land was predominantly located in the Qinghai Tibet Plateau, Middle-lower Yangtze Plain, Sichuan Basin and surrounding areas, the Yunnan-Guizhou Plateau, and Southern China. The topographical index, annual mean precipitation, humidity index, and population density were identified as the most significant factors influencing CA suitability. The CA suitability maps generated in this study will guide the development and extension agents targeting CA to suitable locations with a high potential impact, thereby maximizing the likelihood of adoption and minimizing the risk of failure.