Global COVID-19 Pandemic Research Articles

Evidence of SARS-CoV-2 Spread in Rural Tanzania During the First 6 Months of the Global COVID-19 Pandemic.

In the first 6 months of the coronavirus disease 2019 pandemic, limited testing clouded understanding of the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in Africa. In particular, Tanzania halted all testing and reporting of SARS-CoV-2 cases after May 2020, not resuming until June 2021. In July-August 2020, we performed a seroprevalence survey in rural Bagamoyo district, 40 km outside Dar es Salaam. Among 347 asymptomatic children and adults, 64/347 (18.0%) demonstrated seroreactivity to SARS-CoV-2 spike receptor binding domain by ELISA. Given significant antibody cross-reactivity in malaria-endemic regions, seropositivity was additionally confirmed via a multitarget Luminex immunoassay. Thirty-seven, or 58% of initially seroreactive persons, were Luminex positive, leading to an estimated SARS-CoV-2 seroprevalence of 10.7% (37/347, 95% CI 7.6-14.4%). Working in health care appeared to be associated with seropositivity. Reporting of viral symptoms or health care-seeking behavior in the previous 3 months was not more frequent in seropositive individuals.

Quality of Life of Adolescents and Young Adult Survivors of Childhood Cancer: A Qualitative Study.

To analyse how adolescents and young adults who survived childhood cancer experience their quality of life and to explore their meanings and conceptualisations of quality of life. Narrative design following Squire's method. In-person and virtual recruitment, due to the global COVID-19 pandemic, was carried out in Brazil between May and November 2021. Eighteen semi-structured virtual interviews were conducted with childhood cancer survivors. These data were analysed using reflexive thematic analysis and employing a triangulation of investigators. Four subthemes were identified, encompassing participants' perceptions and meanings of quality of life. Through the reflection and synthesis of these subthemes, a central theme emerged entitled 'New self', capturing the profound impact of the cancer and survival experience on every aspect of the self, along with participants' sense of having gained 'a new life' and a 'second chance'. The study provides a rich and nuanced understanding of quality of life for childhood cancer survivors. The results highlight that after all the changes in life due to cancer, integrating the new self becomes a central aspect of quality of life for survivors. Recognising the profound shifts in self-perception that survivors of childhood cancer undergo, nurses should engage early in empowering patients and families, offering education, space and support to help adolescents and young adults grow throughout their journey. The richness and depth inherent in qualitative data on quality of life can inform the development of care standards and health policies for survivors, guide the allocation of strategic resources and shape the development of plans and interventions focusing on childhood cancer survivors. The COREQ checklist was used. No patient or public contribution.

An artificial intelligence-enabled consumables tracking system for medical laboratories

Abstract The medical laboratory plays a crucial role within a hospital setting and is responsible for the examination and analysis of patient specimens to accurately diagnose various ailments. The burden on medical laboratory personnel has significantly increased, particularly in the context of the ongoing global COVID-19 pandemic. Worldwide, the implementation of comprehensive and extended COVID-19 screening programs has placed a significant strain on healthcare professionals. This burden has led to exhaustion among medical employees, limiting their ability to effectively track laboratory resources, such as medical equipment and consumables. Therefore, this study proposed an artificial intelligence (AI)-based solution that contributes to a more efficient and less labor-intensive workflow for medical workers in laboratory settings. With the ultimate goal to reduce the burden on healthcare providers by streamlining the process of monitoring and managing these resources, the objective of this study is to design and develop an AI-based system for consumables tracking in medical laboratories. In this work, the effectiveness of two object detection models, namely, YOLOv5x6 and YOLOv8l, for the administration of consumables in medical laboratories was evaluated and analyzed. A total of 570 photographs were used to create the dataset, capturing the objects in a variety of settings. The findings indicate that both detection models demonstrate a notable capability to achieve a high mean average precision. This underscores the effectiveness of computer vision in the context of consumable goods detection scenarios and provides a reference for the application of real-time detection models in tracking systems within medical laboratories.

SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization

BackgroundSARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.MethodsHere, we integrated bioinformatic analysis of COVID-19 RNA-seq data from the GEO database and performed functional studies to explore the regulatory role of SARS-CoV-2 in solid tumor progression, including lung, colon, kidney and liver cancer.ResultsOur results demonstrate that infection with SARS-CoV-2 is associated with a decreased expression of genes associated with cancer proliferation and metastasis in lung tissues from patients diagnosed with COVID-19. Several cancer proliferation or metastasis related genes were frequently downregulated in SARS-CoV-2 infected intestinal organoids and human colon carcinoma cells. In vivo and in vitro studies revealed that SARS-CoV-2 nucleocapsid (N) protein inhibits colon and kidney tumor growth and metastasis through the N-terminal (NTD) and the C-terminal domain (CTD). The molecular mechanism indicates that the N protein of SARS-CoV-2 interacts with YBX1, resulting in the recruitment of PKM mRNA into stress granules mediated by G3BP1. This process ultimately destabilizes PKM expression and suppresses glycolysis.ConclusionOur study reveals a new function of SARS-CoV-2 nucleocapsid protein on tumor progression.

Financial Crisis Arising in Small-Scale Industries After Pandemic Periods

The global COVID-19 pandemic has deeply impacted the economy, with small-scale industries (SSIs) facing severe financial crises. These industries, which are the backbone of many economies due to their contribution to employment and GDP, were disproportionately affected by the pandemic. This research article will focus on the financial challenges faced by SSIs post-pandemic, specifically addressing diminished demand, cash flow constraints, supply chain disruptions, and obstacles in securing financial assistance.This paper explores the financial challenges encountered by small-scale industries during and after the pandemic, focusing on liquidity crunches, disruptions in supply chains, reduced consumer demand, and labour shortages. Furthermore, it examines the recovery strategies employed by SSIs and suggests long-term solutions for resilience against future crises.

A review of UK primary care pathways for acute ophthalmic conditions.

Care pathways for the management of acute ophthalmic conditions have developed and transformed significantly over recent years, owing to a combination of legislative changes, policy implementation and the pressing requirement to redistribute increased demand away from traditional secondary care providers through collaboration with primary care. Following UK healthcare devolution in 1999, each nation has developed and implemented their own strategies for managing the growing demands on acute ophthalmology services. Local commissioning across England has seen Enhanced Service Pathways develop to provide acute eye care by primary care optometrists, with provision and access dependent upon locality. Northern Ireland has seen the implementation of a nationwide Primary Eyecare Acute Referral Service, whilst in Scotland and Wales, the respective Governments have redesigned primary care optometry General Ophthalmic Service contracts to incorporate provision of extended investigations and management of acute conditions by optometrists across the nation, recognising the added benefit of optometrists with higher qualifications. This narrative review summarises both peer reviewed and appropriate grey literature articles reporting on acute eye care pathways in primary care. Despite significant progress, particularly during the global COVID-19 pandemic, there is arguably still a great deal of further research and evaluation required relating to pathway innovation, the role of professionals with higher qualifications, including independent prescribing, the role of telemedicine, reassurance around clinical safety, and how digital interconnectivity could potentially add value to collaborative schemes to meet the growing demand on acute eyecare.

Exploring B-cell epitope conservation and antigenicity shift in current COVID-19 variants: Analyzing spike-antibody interactions for therapeutic uses

SARS-CoV-2, responsible for the global COVID-19 pandemic, has undergone significant genetic changes, leading to various variants impacting transmissibility, severity, and vaccine efficacy. The methodology involved evaluating SARS-CoV-2 variants designated by WHO as Variants of Interest (VOIs) and Variants Under Monitoring (VUMs). Several noteworthy mutations including G446S, K417N, T478K, E484A, N501Y, and Y505H exhibit a strong pattern of convergent evolution across all these variants, particularly at antigenic sites within the spike protein. Conformational epitopes mapping and antigenicity shift analyses implicated epitope changes which were compared for therapeutic purposes. VUMs BA.2.86 and XBB.2.3 show significant antigenicity changes and epitope dynamics, correlating with high root mean square deviation values and epitope expansions or contractions. Nonsynonymous mutations are predominant in all variants, suggesting functional changes affecting transmissibility and immune evasion. VOIs XBB.1.5, BA.2.86, and CH.1.1 show high solvent-accessible surface area and radius of gyration, indicating structural expansion and increased epitope availability. In contrast, stable VOI EG.5.1 displays minimal structural changes and moderate epitope expansions. We evaluated two classes of antibodies for their effectiveness in neutralizing SARS-CoV-2 variants. Antibodies CC12.1 and P4A1 from Class I, alongside CV07-250, P5A-2G9, and MW05 from Class II, display strong binding across multiple variants, indicating broad neutralizing capabilities. Specifically, P4A1 shows the highest affinity for EG.5 and EG.5.1, while MW05 exhibits the strongest binding to XBB.1.5, CH.1.1, and XBB.2.3, highlighting their potent neutralization potential. This study aims to elucidate epitope variations in evolving SARS-CoV-2 strains, offering critical insights for developing targeted interventions against current challenges posed by the virus.

Building Sports Brand and Fan Relationships Through Social Media During Covid-19 Pandemic and Post Pandemic Era

This study aims to investigate the measures taken by professional hockey clubs in Sweden for building brand and relationship with fans through social media (SM) during the global pandemic Covid-19. The study followed an inductive approach and qualitative method. Data were collected from officials and fans of three well-known Swedish Hockey league (SHL) teams through semi-structured interviews. A content analysis was undertaken to analyze the collected responses from the club officials and fans. The findings provide insight on the actions taken by the clubs to build their brand and fan relationships through SM. The study provides a framework signifying the important factors that sports organizations need to focus on while building their brand and fan relationships during a global pandemic and in the post pandemic era.

Private equity buyouts & firm exporting in crisis periods: Exploring a new channel

This paper examines whether private equity (PE)-backed companies are better able to remain active on export markets compared to similar non-PE firms, when hit by a negative shock. We look at two such recent shocks, namely the global financial crisis (GFC) and COVID-19 pandemic. We construct two matched samples, one for each crisis period, to assess the resilience of exporting under PE ownership in recessionary periods. We then explore how improvements in working capital management allow PE-backed firms to engage in international activities and maintain their export relationships relative to similar, non-PE-backed firms. Our results show that the export activities of PE-backed firms are significantly more resilient to the effects of the GFC but less pronounced following COVID-19. PE investment enhances working capital management, which in turn improves the persistence in export markets at the onset of the crises.

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants.

The recent global COVID-19 pandemic has highlighted treatments for coronavirus infection as an unmet medical need. The main protease (Mpro) has been an important target for the development of SARS-CoV-2 direct-acting antivirals. Nirmatrelvir as a covalent Mpro inhibitor was the first such approved therapy. Although Mpro inhibitors of various chemical classes have been reported, they are generally less active against nirmatrelvir-resistant variants and have limited pan-coronavirus potential, presenting a significant human health risk upon future outbreaks. We here present a novel approach and utilized DNA-encoded chemical library screening to identify the noncovalent Mpro inhibitor 5, which demonstrated a distinct binding mode to nirmatrelvir. A macrocyclization strategy designed to lock the active conformation resulted in lactone 12 with significantly improved antiviral activity. Further optimization led to the potent lactam 26, which demonstrated exceptional potency against nirmatrelvir-resistant variants as well as against a panel of viral main proteases from other coronaviruses.

P70S6K as a Potential Anti-COVID-19 Target: Insights from Wet Bench and In Silico Studies.

The onset of SARS-CoV-2 infection in 2019 sparked a global COVID-19 pandemic. This infection is marked by a significant rise in both viral and host kinase activity. Our primary objective was to identify a pivotal host kinase essential for COVID-19 infection and the associated phenomenon of the cytokine storm, which may lead to long-term COVID-19 complications irrespective of viral genetic variations. To achieve this, our study tracked kinase phosphorylation dynamics in RAW264.7 macrophages following SPIKE transfection over time. Among the kinases surveyed, p70S6K (RPS6KB1) exhibited a 3.5-fold increase in phosphorylation at S418. This significant change prompted the selection of p70S6K for in silico investigation, utilizing its structure bound to M2698 (PDB: 7N93). M2698, an oral dual Akt/p70S6K inhibitor with an IC50 of 1.1 nM, exhibited psychosis side effects in phase I clinical trials, potentially linked to its interaction with Akt2. Our secondary objective was to discover a small-molecule analogue of M2698 that exhibits a distinct binding preference for p70S6K over Akt2 through computational modeling and analysis. The in silico part of our project began with validating the prediction accuracy of the docking algorithm, followed by an OCA analysis pinpointing specific atoms on M2698 that could be modified to enhance selectivity. Subsequently, our investigation led to the identification of an analog of M2698, designated as S34, that showed a superior docking score towards p70S6K compared to Akt2. To further assess the stability of S34 in its protein-ligand (PL) complexes with p70S6K and Akt2, MD simulations were conducted. These simulations suggest that S34, on average, forms two hydrogen bond interactions with p70S6K, whereas it only forms one hydrogen bond interaction with Akt2. This difference in hydrogen bond interactions likely contributed to the observed larger root mean square deviation (RMSD) of 0.3 nm in the S34-Akt2 complex, compared to 0.1 nm in the S34-p70S6K complex. Additionally, we calculated free binding energy to predict the strength of the binding interactions of S34 to p70S6K and Akt2, which showed ~2-fold favorable binding affinity of S34 in the p70S6K binding pocket compared to that in the Akt2 binding pocket. These observations may suggest that the S34-p70S6K complex is more stable than the S34-Akt2 complex. Our work focused on identifying a host kinase target and predicting the binding affinity of a novel small molecule to accelerate the development of effective treatments. The wet bench results specifically highlight p70S6K as a compelling anti-COVID-19 target. Meanwhile, our in silico investigations address the known off-target effects associated with M2698 by identifying a close analog called S34. In conclusion, this study presents novel and intriguing findings that could potentially lead to clinical applications with further investigations.

The 2020 Olympic Games’ impact on Japan’s image from German and American perspectives: perils of COVID or the fails of the Olympics?

ABSTRACT This study investigated the influence of the 2020 Tokyo Olympic Games on Japan’s country and destination images from German and American perspectives while the event took place under strict restrictions due to the global pandemic of COVID-19. The image of Japan before, during, and after the Games and the Olympic Games image and the pandemic’s influence on the Games were measured. The findings revealed that the Americans had significantly stronger positive images of Japan and the Olympics than the Germans. Overall, there was a strong positive correlation between the Olympic Games image and the country and destination images of the host country, indicating a potential spillover effect.

The role of platelets and megakaryocytes in sepsis and ARDS.

Since the global COVID-19 pandemic, there has been a renewed focus on lung injury during infection. Systemic inflammatory responses such as acute respiratory distress syndrome (ARDS) and sepsis are a leading cause of morbidity and mortality for both adults and children. Improvements in clinical care have improved outcomes but mortality remains ∼40% and significant morbidity persists for those patients with severe disease. Mechanistic studies of the underlying biological processes remain essential to identifying therapeutic targets. Furthermore, methods for identifying the underlying drivers of organ failure are key to treating and preventing tissue injury. In this review, we discuss the contribution of megakaryocytes (MKs) and platelets to the pathogenesis of systemic inflammatory syndromes. We explore the role of MKs and the new identification of extramedullary MKs during sepsis. We describe the alterations in the platelet transcriptome during sepsis. Lastly, we explore platelet function as defined by aggregation, activation and the formation of heterotypic aggregates. Much more work is necessary to explore the contribution of platelets to these heterogenous syndromes, but the foundation of platelets as key contributors to inflammation has been laid.

Mapping the Evolution of Digital Health Research: Bibliometric Overview of Research Hotspots, Trends, and Collaboration of Publications in JMIR (1999-2024).

While bibliometric studies of individual journals have been conducted, to the best of our knowledge, bibliometric mapping has not yet been utilized to analyze the literature published by the Journal of Medical Internet Research (JMIR). In celebration of the journal's 25th anniversary, this study aimed to review the entire collection of JMIR publications from 1999 to 2024 and provide a comprehensive overview of the main publication characteristics. This study included papers published in JMIR during the 25-year period from 1999 to 2024. The data were analyzed using CiteSpace, VOSviewer, and the "Bibliometrix" package in R. Through descriptive bibliometrics, we examined the dynamics and trend patterns of JMIR literature production and identified the most prolific authors, papers, institutions, and countries. Bibliometric maps were used to visualize the content of published articles and to identify the most prominent research terms and topics, along with their evolution. A bibliometric network map was constructed to determine the hot research topics over the past 25 years. This study revealed positive trends in literature production, with both the total number of publications and the average number of citations increasing over the years. And the global COVID-19 pandemic induced an explosive rise in the number of publications in JMIR. The most productive institutions were predominantly from the United States, which ranked highest in successful publications within the journal. The editor-in-chief of JMIR was identified as a pioneer in this field. The thematic analysis indicated that the most prolific topics aligned with the primary aims and scope of the journal. Currently and in the foreseeable future, the main themes of JMIR include "artificial intelligence," "patient empowerment," and "victimization." This bibliometric study highlighted significant contributions to digital health by identifying key research trends, themes, influential authors, and collaborations. The findings underscore the necessity to enhance publications from developing countries, improve gender diversity among authors, and expand the range of research topics explored in the journal.

Acute and long-term SARS-CoV-2 infection and neurodegeneration processes—circulus vitiosus

The global pandemic of COVID-19 caused by SARS-CoV-2 has had a devastating impact. Although many survived the acute effects of the pandemic, a significant number of survivors, including those with only mild symptoms, are now experiencing a prolonged and debilitating post-viral syndrome known as LC/PASC (long COVID/post-acute sequelae of SARS-CoV-2). Typical symptoms of LC/PASC include fatigue, breathlessness, chest pain, impaired cognition, difficulty sleeping, fever and gastrointestinal symptoms. Anxiety and depression can also last for weeks to months and range from mild to disabling. The association between neuropsychiatric symptoms and SARS-CoV-2 infection raises questions about the possible routes of SARS-CoV-2 entry to the central nervous system (CNS) and long-term effects of the virus on the CNS, their molecular basis, and the potential risk of neuronal damage associated with the subsequent development of neurodegenerative diseases.

How early onset of COVID-19 changed vaccine-related attitudes: A longitudinal study

The paper investigates how the onset of the global COVID-19 pandemic has influenced the attitudes and beliefs of a previously anti-vaccine and vaccine-undecided population: how it changed their anti-vaccine beliefs and related arguments, perceptions of scientists’ credibility, as well as what their beliefs about COVID-19 are and what protective action they undertake against it. We used preexisting data from a 2018 study, where we identified groups of anti-vaccine and vaccine-undecided individuals (N = 365) whom we reached out to again in April/May 2020 (during the first months of the pandemic, when no COVID-19 vaccine was available). An online survey was used to measure changes in attitudes toward vaccination, reasons for vaccine rejection, attitudes toward scientists, and (at Measure 2) to measure attitudes toward COVID-19 and protective action against it. Results indicated a general pro-vaccine shift in attitudes, as well as reduced support for all anti-vaccine arguments. Surprisingly, we also found a negative shift in the sample’s perceptions of scientists’ agency and communion. Anti-vaccine individuals were also much less likely to employ any protective measures and had the lowest levels of fear associated with COVID-19. These results show that the initial stages of the COVID-19 outbreak caused a positive change in vaccine attitudes, especially in the vaccine-undecided group. At the same time, strongly anti-vaccine individuals were likely to reject protection against COVID.

Pricing of timer volatility-barrier options under Heston’s stochastic volatility model

Timer options are financial instruments that enable investors to exercise their rights on a random maturity date the realized variance reaches the level of variance budget. These options provide a stable investment opportunity for investors under the unpredictable and complex financial markets, such as global financial crisis or COVID-19 pandemic, which can induce the drastic changes of the volatility for the underlying asset. Meanwhile, in the financial markets, investors who invest in standard timer options may face the problems caused by the postponement of the exercising time for too low volatility, compared to standard vanilla options. In this regard, to overcome such disadvantages, we propose timer volatility-barrier options, which are activated and expired when the volatility arrives at a relatively low barrier level, with the original properties of the standard timer options. In this paper, by making use of the method of images, we derive an analytical formulas for the timer volatility-barrier options so that the volatility process can be driven by Heston stochastic volatility model, and verify the pricing accuracy of the timer options by comparing our solutions with those obtained from Monte Carlo simulations. Finally, we conduct numerical studies on the timer volatility-barrier options to examine the pricing sensitivities with respect to the various model parameters, and implement the discussion for pricing formula of double volatility barrier type of the timer options.

COVID-19 and Reproductive Function: A Detailed Review of Fertility Outcomes, Sperm Alterations, and Vertical Transmission Concerns

Background:The global COVID-19 pandemic, caused by SARS-CoV-2, raises concerns about its effects on reproductive health. Emerging evidence suggests potential impacts on male and female fertility, including hormonal changes, immune responses, and organ damage, though the virus’s direct influence on reproductive tissues and vertical transmission remains unclear. Objective:This review summarizes current evidence on COVID-19’s effects on male and female reproductive health, focusing on sperm count, fertility, and vertical transmission. Methods:A comprehensive literature review was conducted using databases such as PubMed, Scopus, and Web of Science. Peer-reviewed studies were included based on their relevance to reproductive outcomes, sperm count, hormonal changes, and vertical transmission of SARS-CoV-2. Results:Most studies found no direct evidence of SARS-CoV-2 in male or female reproductive tissues. However, a temporary decline in sperm count and quality has been reported in men recovering from COVID-19. Hormonal fluctuations, particularly increased luteinizing hormone (LH) levels, were observed in some male patients. In females, the presence of ACE2 receptors in reproductive organs suggests a potential risk, but no conclusive evidence of impaired fertility has been found. Vertical transmission remains uncertain, with isolated cases reporting elevated IgM antibodies in newborns. Conclusion:Although direct evidence of SARS-CoV-2 impacting fertility is limited, temporary reproductive disruptions in males, including reduced sperm count, have been noted. The risk of vertical transmission remains unclear. Further research is essential to determine COVID-19’s long-term reproductive effects.

Post-pandemic positions: new perspectives on international education and public diplomacy in Australia

PurposeIn an era of internationalism, higher education and vocational training have been core to Australia’s nation-building, regional co-operation and public diplomacy. This essay examines what has become of the people-to-people aspect of Australia’s engagements in the Indo-Pacific region, as discussed in the Australian government’s influential White Paper on Australia in the Asian Century (2012). More recently, established patterns of international educational exchange, and their economic, social and cultural benefits, have been disrupted by the global COVID-19 pandemic, shifting international relations and domestic politics, with consequences for international education and public diplomacy.Design/methodology/approachThis essay introduces the scholarly context for a reappraisal of Australian histories of international education within the Indo-Pacific region since the mid-20th century, and the role of NGOs, academia and government in educational schemes and scholarships. It draws on an approach informed by international history, the history of education and diplomatic studies, to provide an overview of key themes and the past and present case studies discussed in the seven articles of this special journal issue.FindingsThe little-known histories of international education in Australia, and associated scholarship schemes, are important aspects of soft power or public diplomacy and the nation’s relations with the Indo-Pacific region. We argue that there needs to be greater acknowledgement of the vital role of these interpersonal interactions and the international organisations that facilitated such exchanges in histories of Australia’s internationalism and diplomacy. While Australian governments have initiated scholarship programmes, what is becoming clear is that understanding their significance for Australian–regional relationships demands a research focus on student expectations and experiences that often lay beyond government control.Originality/valueThis essay and the articles in this special issue offer new historic and current insights on international education policy and programmes and Australia’s diplomatic relations. Many of the highlighted case studies have not previously been analysed within this context, and fresh analysis makes an intervention into the field, revealing the complexities and limitations of international education and people-to-people relationships for Australia’s past and present connections with the Indo-Pacific region.

Digital finance infrastructure and growth of commercial banking firms in Nigeria

This study delves into the intricate relationship between digital finance infrastructure and the growth of commercial banking firms in Nigeria. Through a comprehensive analysis of various financial indicators and statistical tests, we offer critical insights into the dynamics of the Nigerian banking sector. The findings reveal a resilient and steadily growing banking industry, even in the face of economic challenges and the global COVID-19 pandemic. Key highlights include the exponential rise in digital infrastructure, exemplified by the proliferation of Automated Teller Machines (ATMs), Point of Sale (POS) machines, and web banking accounts. These digital channels have significantly influenced the accessibility and convenience of banking services in Nigeria. Our analysis employs correlation, regression, and Granger causality tests to explore the intricate relationships between bank total assets and digital infrastructure components. While positive correlations between bank total assets and digital infrastructure components suggest a strong link between technological expansion and banking growth, the analysis reveals nuanced relationships. Furthermore, while web banking accounts have grown significantly, their influence on bank total assets remains limited. Our findings emphasize the paramount importance of continued investments in digital finance infrastructure for the Nigerian banking sector's growth. However, they also underscore the need for a more profound understanding of the underlying drivers of these trends. This study offers valuable insights for policymakers, financial institutions, and researchers interested in fostering financial inclusion and optimizing digital banking services in Nigeria's ever-evolving financial landscape. In conclusion, this study highlights the critical role of digital finance infrastructure in driving the growth of commercial banking firms in Nigeria, while also calling for more targeted strategies to maximize the benefits of technological advancements in the banking sector.