Global COVID-19 Pandemic Research Articles

Questionnaire Survey on Perception and Attitude Toward of Remote Treatment by Korean Medicine Doctors

Objectives: Following the global COVID-19 pandemic, with the escalation of remote medical care formalization in Korea, there is a pressing need for objective data in the Korean medicine field to respond to remote treatment medical care policies. This study aims to investigate the perceptions and acceptance of remote treatments among Korean Medicine Doctors (KMDs).Methods: After expert reviews and pilot testing, the 31-question survey covered participant characteristics, experiences, forms, intentions, and perceptions related to Remote Treatments. The survey was electronically distributed to members of the Association of Korean Medicine, and 662 clinical KMDs provided valid responses.Results: Among respondents, 76.1% engaged in remote treatments, utilizing various platforms. Those with experience in Remote Treatments showed a significantly higher willingness to continue participating during the institutionalization process (p<0.001). 49.7% of respondents stated that traditional Korean medicine is competitive in remote treatments, with the main reasons being the ability for regular management after herbal medication(26.1%) and increased patient satisfaction due to sufficient counseling compared to Western medicine(25.2%). Respondents preferred Remote Treatment conditions with a treatment time of less than 10 minutes(47.6%) and equivalent fees to in-person visits(45.6%). Regarding suitable intervention tools during Remote Treatment, respondents favored non-covered herbal prescriptions(39.0%), covered herbal granules(24.6%), and non-covered herbal granules(23.0%).Conclusion: This study investigated the perceptions and acceptance of KMDs regarding remote treatments. These findings provide valuable insights for policymakers aiming to establish effective policies for Remote Treatments suitable for the Korean medicine healthcare environment.

The Three Rs of Fear Messaging in a Global Pandemic: Recommendations, Ramifications and Remediation.

We consider the UK Independent Scientific Pandemic Insights Group on Behaviours' (SPI-B) support for fear messaging during the global COVID-19 pandemic, evaluate the consequences and make recommendations for the future. Using evidence from published documents, we show that SPI-B supported the use of fear messaging during the COVID-19 pandemic. This is inconsistent with the extant psychological literature and contrary to the disaster planning literature. The recommendations regarding fear messaging may have had harmful ramifications and impacts, especially for young people. We recommend that a wider multidisciplinary expertise is employed to deal effectively, ethically and holistically with future crises. Plans for future pandemics must include meaningful engagement with the public, particularly children and young people.

The Effects of Online Learning Platforms on Student Engagement and Academic Performance

The rapid proliferation of Online Distance Learning (ODL) platforms, accelerated by the global COVID-19 pandemic, has transformed the educational landscape, necessitating a revaluation of their impacts on student engagement and academic performance. This study aims to explore the nuanced effects of ODL on undergraduate students, specifically focusing on the challenges and benefits associated with its use. Employing a quantitative research design, this research utilized an online survey modified from existing instruments to suit the study's objectives. The survey, comprising both Likert scale and open-ended questions, was designed to capture students' experiences, engagement levels, and academic outcomes related to ODL. The target population included final-year undergraduate students from the Faculty of Civil Engineering at Universiti Teknologi MARA (UiTM) Penang, with purposive sampling ensuring a focused examination of the impacts of ODL within this specific academic context. Data were collected from 36 participants via Google Forms and analysed using IBM SPSS, revealing significant correlations between the use of digital tools, student engagement, and perceived academic performance. Key findings indicate that while digital tools are integral to ODL, their usage is associated with increased feelings of isolation, distraction, and negative impacts on sleep patterns. However, students also recognized the benefits of digital learning, such as flexibility and accessibility. The study concludes that the effectiveness of ODL platforms is contingent upon balancing digital tool usage with strategies to mitigate their potential drawbacks, emphasizing the need for interactive elements that mimic face-to-face interactions and support services to address students' psychological well-being. This research contributes to the ongoing discourse on the efficacy of online learning, offering insights into optimizing ODL environments to enhance student engagement and performance while ensuring their mental and social well-being.

Innovative learning spaces: Visions for the future(s) of education

This article has its origins in the work of an International Society for Education through Art (InSEA) focus group formed in 2020 to respond to a UNESCO consultation on the ‘future(s)’ of education. The membership of the group spanned four continents and we met online during 2020, a period when most of the world was in lockdown due to the global COVID-19 pandemic. The group reflected and envisioned possible social, cultural, economic and environmental challenges in future and focused on how the visual arts can meet these challenges. Our focus group looked into the crystal ball and tried to imagine the circumstances in which education through art may take place in future. We imagined how knowledge, learning and education might shape the future of humanity. In short, we addressed how the collective purposes of education may change including what, how and where we learn.

Evil Re-Examined: Barthian Insights Post-Covid Pandemic

This paper delves into Karl Barth's unique interpretation of evil within the context of the 2019-2022 global COVID-19 pandemic, guided by Kenneth Surin's concept of 'practical theodicy.' Employing a critical analysis of Barth's theological works, with a particular focus on 'das Nichtige' (nothingness), it uncovers a fresh understanding of Barth's theological intentions concerning the problem of evil. Barth's theology highlights the inherent malevolence of evil and its ultimate defeat through Christ, providing a theological framework for addressing post-pandemic suffering challenges. This reinterpretation holds specific relevance for Indonesia's and global Christian community, offering a practical theological foundation for navigating the pandemic's aftermath. The research's implications extend to theology and ethics, offering a new perspective on how Christians can comprehend and respond to suffering in a post-pandemic world. Informed by 'practical theodicy,' Barth's theological insights prompt a reconsideration of our approach to evil and its implications for human existence. This paper reevaluates Karl Barth's theology of evil through a contemporary lens, presenting a novel interpretation that is particularly valuable to scholars and theologians seeking fresh viewpoints on the enduring issue of suffering. Moreover, it offers practical guidance for Indonesia's Christian community in addressing the challenges posed by the global pandemic.

Intimate Selves: A Poetic Inquiry into Self-Knowledge

This article uses poetic inquiry to explore the author’s experiences of the global COVID-19 pandemic, which brought about a State of Disaster in South Africa from 26 March 2020 to 5 April 2022. The author had, before the pandemic, been used to going to an office and interacting with colleagues every day, and was not used to spending long periods of time alone. The poetry presented in this article was written during, and about, time the author spent alone during the pandemic and afterwards. The methodology of poetic inquiry, which was introduced as a scholarly approach in the 1970s (Davis, 2023), is used to reflect on the poems. Poetic inquiry typically fashions a poem from research data, instead of presenting the data according to the conventional schema for reporting (for example, with separate sections for ‘Findings’, ‘Data Analysis’, and ‘Conclusions’). Advocates of poetic inquiry find it an apt method for reducing data to a much more manageable corpus. In addition, it enables researchers to include affect, and to use evocative figurative language. The article uses the author’s subjective experiences as research data, presents the poems crafted from them, and comments on the poetry.

Global VAX: A U.S. contribution to global COVID-19 vaccination efforts, 2021–2023

In December 2021 the U.S. Government announced a new, whole-of-government $1.8 billion effort, the Initiative for Global Vaccine Access (Global VAX) in response to the global COVID-19 pandemic. Using the foundation of decades of U.S. government investments in global health and working in close partnership with local governments and key global and multilateral organizations, Global VAX enabled the rapid acceleration of the global COVID-19 vaccine rollout in selected countries, contributing to increased COVID-19 vaccine coverage in some of the world’s most vulnerable communities. Through Global VAX, the U.S. Government has supported 125 countries to scale up COVID-19 vaccine delivery and administration while strengthening primary health care systems to respond to future health crises. The progress made by Global VAX has paved the way for a stronger global recovery and improved global health security.

Lessons Learned from Cross-Systems Approach to COVID-19 Pandemic Response in Juvenile Justice System, Colorado, USA.

The global COVID-19 pandemic illustrates the importance of a close partnership between public health and juvenile justice systems when responding to communicable diseases. Many setting-specific obstacles must be navigated to respond effectively to limit disease transmission and negative health outcomes while maintaining necessary services for youth in confinement facilities. The response requires multidisciplinary expertise and collaboration to address unique considerations. Public health mitigation strategies must balance the risk for disease against the negative effects of restrictions. Key aspects of the COVID-19 response in the juvenile justice system of Colorado, USA, involved establishing robust communication and data reporting infrastructures, building a multidisciplinary response team, adapting existing infection prevention guidelines, and focusing on a whole-person health approach to infection prevention. We examine lessons learned and offer recommendations on pandemic emergency response planning and managing a statewide public health emergency in youth confinement settings that ensure ongoing readiness.

Strategy development to increase consumer intention of purchasing prescription drugs through e-pharmacy in Indonesia.

The global COVID-19 pandemic has forced people to obtain health products and services from home. Similar to other e-commerce, medicines are bought online and delivered using a courier service. By being fully concerned to patient safety, this study aims to determine development strategies to increase intention in purchasing prescription drugs through e-pharmacy. Two stages of measurement are employed in this study, namely confirmatory factor analyis using PLS-SEM and pairwise comparison using AHP method. To discover consumer perception in using e-pharmacy, the basic model of Theory of Planned Behavior (TPB) is employed with several extensions. The results of PLS-SEM express that Trust has a major role as an intervening variable to enhance the indirect effect of Subjective Norms and Perceived Values on Purchase Intention. In general, PLS-SEM structural model is declared "fit" (GFI = 0.93 ≥ 0.90; RMSEA = 0.045 ≤ 0.08; SRMR = 0.033 ≤ 0.05). Measurement model test proves that all selected indicators are valid to represent their related constructs (Loading Factor ≥ 0.50), and all selected constructs are reliable to build the whole path model (CR ≥ 0.7; AVE ≥ 05). Meanwhile, the results of AHP indicate that strengthening government policies and regulations is prioritized to increase consumer intention of purchasing prescription drugs through e-pharmacy, followed by protection of user confidential data in the second place. Those two eigenvectors are 0.236 and 0.185 respectively. Future research is suggested to add perceived risk as latent variable in the study of consumer behavior for any high-risk products.

The characteristics of BCR-CDR3 repertoire in COVID-19 patients and SARS-CoV-2 vaccinated volunteers.

The global COVID-19 pandemic has caused more than 1 billion infections, and numerous SARS-CoV-2 vaccines developed rapidly have been administered over 10 billion doses. The world is continuously concerned about the cytokine storms induced by the interaction between SARS-CoV-2 and host, long COVID, breakthrough infections postvaccination, and the impact of SARS-CoV-2 variants. BCR-CDR3 repertoire serves as a molecular target for monitoring the antiviral response "trace" of B cells, evaluating the effects, mechanisms, and memory abilities of individual responses to B cells, and has been successfully applied in analyzing the infection mechanisms, vaccine improvement, and neutralizing antibodies preparation of influenza virus, HIV, MERS, and Ebola virus. Based on research on BCR-CDR3 repertoire of COVID-19 patients and volunteers who received different SARS-CoV-2 vaccines in multiple laboratories worldwide, we focus on analyzing the characteristics and changes of BCR-CDR3 repertoire, such as diversity, clonality, V&J genes usage and pairing, SHM, CSR, shared CDR3 clones, as well as the summary on BCR sequences targeting virus-specific epitopes in the preparation and application research of SARS-CoV-2 potential therapeutic monoclonal antibodies. This review provides comparative data and new research schemes for studying the possible mechanisms of differences in B cell response between SARS-CoV-2 infection or vaccination, and supplies a foundation for improving vaccines after SARS-CoV-2 mutations and potential antibody therapy for infected individuals.

Study on the fit of nonwoven face masks on different face shapes

In the midst of the global COVID-19 pandemic, airborne infectious diseases, including contagious tuberculosis and illnesses transmitted through airborne droplets, such as influenza, SARS, and avian influenza, have emerged as some of the most severe pandemics in human history. Face masks have become an essential everyday item, despite their previous use primarily for the sick. Current mask designs come in various sizes; however, they may not be suitable for all face shapes, particularly for individuals with smaller or frequently moving facial features. Therefore, there is a need for research, especially focusing on women and individuals with smaller faces, to enhance the effectiveness of face masks in providing adequate protection. Accordingly, this study examined the current typical mask design ‘normal mask’ and four proposed mask designs for five face shapes (round, diamond, oval, square, or oblong) by using a quantitative fit test, as suggested in ISO 16975-3 and OSHA 29 CFR1910.134, to determine the masks’ fit factor (FF). The FF of the normal mask was 80% on round faces, 66% on diamond faces, but only 41% on square and oblong faces. The FaceMe artificial intelligence program was used to modify the face mask design in accordance with each face shape, and the level of air leakage was evaluated. The results showed that modifying the mask edges could reduce air leakage, especially during movements. For square faces, the leakage level was reduced from 63% (normal mask) to 38% (line mask). For oblong faces, the normal mask had a leakage level of 63%, whereas wave masks reduced leaking to 34%, resulting in a reduction of almost 30%. Mask fit could also be improved by adjusting earloop tightness.

Heritage Tourism Resilience and Sustainable Performance Post COVID-19: Evidence from Hotels Sector

Heritage tourism in Egypt, differentiated by its distinctive ancient wonders and cultural prosperity, has faced numerous challenges through its history, with political unrest, economic fluctuations, and, most recently, the global COVID-19 pandemic. This research paper investigates the dynamic interplay between planned and adopted resilience within the hotel sector in Egyptian heritage sites and their consequential effects on both social and economic sustainability. A quantitative research method was employed to empirically explore these dynamics. A structured questionnaire was distributed to 550 top and middle managers in hotels located in heritage sites, capturing insights into their perspectives on planned and adopted resilience. The collected data underwent rigorous analysis utilizing “partial least squares structural equation modeling” (PLS-SEM), providing a robust foundation for drawing meaningful conclusions. Findings from the research underscore the necessity of aligning planned and adopted resilience to generate sustainable social and economic performance. The synthesis of planned and adopted resilience was revealed to be pivotal in generating sustainable social and economic performance for hotels. This synthesis catalyzes the hotels’ ability to mitigate uncertainties, adjust to changing environment, and ensure long-term viability. This research might contribute to the current literature by suggesting industry-specific awareness for the reciprocal relationship between planned and adopted resilience in the hotel businesses and their combined influence on both sides of sustainability (social and economic). The findings provide actionable recommendations for hotel management, policymakers, and industry stakeholders to enhance resilience, foster social cohesion, and ensure the economic sustainability of heritage tourism in an everchanging environment.

Effective expression and characterization of the receptor binding domains in SARS-CoV-2 Spike proteins from original strain and variants of concern using Bombyx mori nucleopolyhedrovirus in silkworm

A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the global pandemic of COVID-19 in 2020. Through structural analysis, it was found that several amino acid residues in the human angiotensin-converting enzyme-2 (hACE2) receptor directly interact with those in the receptor binding domain (RBD) of the spike glycoprotein (S-protein). Various cell lines, including HEK293, HeLa cells, and the baculovirus expression vector system (BEVS) with the insect cell line Sf9, have been utilized to produce the RBD. In this study, we investigated the use of Bombyx mori nucleopolyhedrovirus (BmNPV) and BEVS. For efficient production of a highly pure recombinant RBD protein, we designed it with two tags (His tag and STREP tag) at the C-terminus and a solubilizing tag (SUMO) at the N-terminus. After expressing the protein using BmNPV and silkworm and purifying it with a HisTrap excel column, the eluted protein was digested with SUMO protease and further purified using a Strep-Tactin Superflow column. As a result, we obtained the RBD as a monomer with a yield of 2.6 mg/10 mL serum (equivalent to 30 silkworms). The RBD showed an affinity for the hACE2 receptor. Additionally, the RBDs from the Alpha, Beta, Gamma, Delta, and Omicron variants were expressed and purified using the same protocol. It was found that the RBD from the Alpha, Beta, Gamma, and Delta variants could be obtained with yields of 1.4–2.6 mg/10 mL serum and had an affinity to the hACE2 receptor.

How to Improve People's Intentions Regarding COVID-19 Vaccination in China: A Randomized Controlled Trial.

The global COVID-19 pandemic has impaired the health and living conditions of millions of people. For governments to formulate policies promoting vaccination behavior, it is important to understand individuals' intentions to vaccinate. This study explores the effectiveness of a brief online intervention based on the Health Action Process Approach (HAPA) in improving individuals' COVID-19 vaccination intention, as well as considering the reasons for their unwillingness to get vaccinated. A total of 1,258 participants were assessed using a questionnaire to determine their phase of vaccination intention (pre-intention, intention, and action). Subsequently, focused on the underlying factors in the pre-intention phase (i.e., task self-efficacy, outcome expectation, and risk perception), a 7-day randomized controlled HAPA intervention (n intervention = 57, n control = 49) was conducted online for individuals who were not willing to get vaccinated. The measurement points included pre- (T1), post- (T2), and 30-day follow-up (T3). The intervention may effectively improve participants' COVID-19 vaccination intentions; however, it had no impact on their planning and actions involved in taking the vaccine. This study provides relevant reference data for government stakeholders to use in developing public awareness campaigns and policies to encourage COVID-19 vaccination.

Perceived Mental Health among Identified Talented and Nonidentified Students from Indian Villages, Towns, and Cities During the COVID-19 Pandemic

The present study investigates the perception of experience of depression, anxiety, and stress (DAS) among young adults (18–22 years of age) from different locales in India during the global COVID-19 pandemic. The sample included 1,020 participants (603 males and 417 females) with 470 identified talented students (ITS) and 550 nonidentified students (NiS) from Indian villages, towns, and cities. multivariate analysis of variance and ordinal logistic regression analysis were carried out to understand the differences between the various subcategories and the probability of having high negative emotional states among those groups. Results point toward varying levels of DAS depending on whether they were ITS or NiS, whether male or female, and whether they came from Indian villages, towns, or cities. Both similarities and dissimilarities with other studies were observed, and the results provide insights into the effect of the pandemic on the mental health of young adults in India. The importance of developing psychological support systems for all students is implicated in the findings of the study.

Role of clinical pharmacists in multidisciplinary collaborative management of blood glucose in COVID-19 patients with hyperglycemia

BackgroundDuring the ongoing global pandemic of COVID-19, the association between hyperglycemia and COVID-19 infection has emerged as a notable concern. Therefore, finding effective methods to manage hyperglycemia in patients with COVID-19 is crucial. ObjectiveTo introduce the clinical pharmacists participating in multidisciplinary collaborative whole hospital blood glucose management mode, and to explore its effect on blood glucose control in patients with coronavirus disease 2019 infection and complicated with hyperglycemia. MethodsPatients with COVID-19 treated at Nanjing Drum Tower Hospital from December 2022 to January 2023 were assigned to routine diagnosis and treatment group and whole hospital blood glucose management group according to the blood glucose management plan received by patients. The groups were compared in regards to their adherence to management advice, blood glucose levels, fluctuation, inflammation-related indicators, medical service-related indicators, and incidence of hypoglycemia and adverse events. ResultsAfter 5 days of glucose management, both groups showed a decrease in fasting and postprandial blood glucose. Postprandial blood glucose in the whole hospital glucose management group was significantly lower than the routine group (P < 0.05). The whole hospital glucose management group showed a significant increase in compliance rate, improved inflammation-related indicators, and higher detection rates for hemoglobin and islet function (P < 0.05). Implementation rates for medical orders and treatment plans were also higher in the whole hospital group (P < 0.05). There was no significant difference in incidence of adverse events. ConclusionsMultidisciplinary blood glucose management is highly recommended for patients with COVID-19 who have hyperglycemia due to its effectiveness, standardization, safety, and improvement of inflammation indicators.

“I Just Know if I Keep Going, I’ll End Up Hating Nursing.” Lived Experiences of Emergency Nurses Three Years Into the Global COVID-19 Pandemic

IntroductionAs the coronavirus disease 2019 pandemic continues globally, the personal and professional pressure on health care workers continues to accumulate. Literature suggests that as the pandemic evolves, nurses are experiencing increased levels of anxiety, depression, and post-traumatic stress, ultimately leading them to voice intentions to leave the profession, if they have not done so already. MethodsInformed by an interpretive hermeneutic phenomenological approach, this longitudinal study was designed to capture how the lived experiences of 9 emergency nurses evolved over the coronavirus disease 2019 pandemic, highlighting their feelings, attitudes, and perceptions toward working in the emergency department at this time in history. Interviews were undertaken in June 2022 and were analyzed using a thematic analysis approach. ResultsData analysis resulted in a total of 2 major themes and 8 minor themes. The 2 major themes included “exposed wounds” and “Band-Aid solutions.” Levels of burnout increased during the pandemic, with most of the emergency nurse participants dropping their hours, moving roles within the profession, or leaving the profession entirely. Findings elucidate where and how concerns may arise in clinical practice and holistic well-being among emergency nurses, particularly surrounding professional boundaries and protecting work-life balance and professional identity. DiscussionAs the world moves to managing coronavirus disease 2019 as a recognized common respiratory illness, providing time and space for emergency nurses to voice their concerns, design their well-being interventions, set professional boundaries, and reconnect with their professional passion may see lower attrition rates and higher levels of professional satisfaction in emergency nurses globally.

A Comparative Analysis of Liver Injury Markers in Post-COVID Syndrome among Elderly Patients: A Prospective Study.

In the wake of the global COVID-19 pandemic, understanding its prolonged impact on vulnerable populations has become a critical area of investigation. This study aimed to elucidate the distinctive post-acute sequelae of SARS-CoV-2 infection (PASC) and liver injury in Romania's elderly population, hypothesizing unique demographic, clinical, and healthcare factors influencing the manifestation. A longitudinal design was employed, enrolling COVID-19 patients from the Victor Babes Hospital for Infectious Diseases and Pulmonology in Timisoara, Romania. Participants were stratified into three groups based on age and Long COVID status. The study focused on a variety of demographic, clinical, and biological parameters, including liver function tests, to assess the trajectory and severity of liver injury over six months post discharge. Involving 238 participants, the study revealed a significant increase in the duration of hospitalization for those over 65 (15.8 ± 8.2 days) compared to younger groups (p < 0.001). Notably, elderly Long COVID patients exhibited a marked elevation in liver enzymes post discharge, with median ΔALT and ΔAST of 24.1 U/L and 30.2 U/L, respectively, suggesting ongoing liver injury (p < 0.001). Significant metabolic disruptions were observed, with the ΔFasting glucose showing a substantial median decrease of 21.1 mmol/L in the elderly group (p < 0.001). A pronounced reduction in ΔGGT (16.7 U/L) and ΔLDH (48.7 U/L) was noted, indicating a recovery in liver function and reduced tissue damage (p < 0.001). Coagulation profiles and liver fibrosis risk scores, particularly ΔFIB-4 and ΔAPRI, also significantly improved post discharge, indicating a reduced risk of ongoing liver complications. This study confirms the hypothesis of more severe PASC and liver injury among the elderly Romanian population. Significant improvements post discharge suggest a degree of recovery, yet the persistent alterations in liver enzymes, glucose metabolism, and fibrosis risk scores call for continued monitoring and tailored management strategies.

The impact of the COVID-19 pandemic on incidence gap in screen-detectable cancers: a cohort study in Greater Poland, Poland.

The global COVID-19 pandemic has had a significant impact on healthcare systems. This study aimed to assess the incidence gap in screening-detectable cancers in the Greater Poland (Poland) in 2020. Data on breast, cervix uteri, and colorectal cancer cases diagnosed from 2010 to 2020 were obtained from the regional cancer registry. Standardized incidence ratios (SIR) and incidence rate differences (IRD) were calculated to estimate the change in incident cancer cases during the pandemic. The number of observed cases was extracted from the registry database. Simple linear regression analysis was used to predict the expected number of incident cancer cases in 2020 and the age-standardized incidence rate based on registry data from the preceding ten years (2010-2019). In 2020, the registered number of incident female breast cancer cases decreased by 12% [SIR 0.88, 95% confidence interval (CI): 0.88-0.92, observed: 1,848, expected: 2,101], resulting in an IRD of -6.3 per 100 K. The number of registered cervical cancers decreased by 15% (SIR 0.85, 95% CI: 0.73-0.98, observed: 181, expected: 213), with an IRD of -0.8 per 100 K. For colorectal cancer, there was a 16% decrease in new cases among females (SIR 0.84, 95% CI: 0.78-0.90) and a 15% decrease among males (SIR 0.85, 95% CI: 0.80-0.91), resulting in IRDs of -3.04 and -5.29 per 100K, respectively. The COVID-19 pandemic led to a significant, 15% decrease in newly diagnosed screening-detectable cancer cases in 2020. Further studies are needed to investigate the impact of delayed cancer diagnoses on stage at diagnosis and survival rates.

Global research on RNA vaccines for COVID-19 from 2019 to 2023: a bibliometric analysis.

Since the global pandemic of COVID-19 has broken out, thousands of pieces of literature on COVID-19 RNA vaccines have been published in various journals. The overall measurement and analysis of RNA vaccines for COVID-19, with the help of sophisticated mathematical tools, could provide deep insights into global research performance and the collaborative architectural structure within the scientific community of COVID-19 mRNA vaccines. In this bibliometric analysis, we aim to determine the extent of the scientific output related to COVID-19 RNA vaccines between 2019 and 2023. We applied the Bibliometrix R package for comprehensive science mapping analysis of extensive bibliographic metadata retrieved from the Web of Science Core Collection database. On January 11th, 2024, the Web of Science database was searched for COVID-19 RNA vaccine-related publications using predetermined search keywords with specific restrictions. Bradford's law was applied to evaluate the core journals in this field. The data was analyzed with various bibliometric indicators using the Bibliometrix R package. The final analysis included 2962 publications published between 2020 and 2023 while there is no related publication in 2019. The most productive year was 2022. The most relevant leading authors in terms of publications were Ugur Sahin and Pei-Yong, Shi, who had the highest total citations in this field. The core journals were Vaccines, Frontiers in Immunology, and Viruses-Basel. The most frequently used author's keywords were COVID-19, SARS-CoV-2, and vaccine. Recent COVID-19 RNA vaccine-related topics included mental health, COVID-19 vaccines in humans, people, and the pandemic. Harvard University was the top-ranked institution. The leading country in terms of publications, citations, corresponding author country, and international collaboration was the United States. The United States had the most robust collaboration with China. The research hotspots include COVID-19 vaccines and the pandemic in people. We identified international collaboration and research expenditure strongly associated with COVID-19 vaccine research productivity. Researchers' collaboration among developed countries should be extended to low-income countries to expand COVID-19 vaccine-related research and understanding.