The fact that two antipodal points in the quaternion characterize the same physical attitude depicts that the design of the global attitude control system is uneasy. This study deals with a smooth quaternion-based attitude tracking control system that is composed of a differential equation known as the augmented dynamical system. The augmented dynamical system plays such an important role that it is possible to conduct a novel perspective on viewing the set containing all possible motions as not a manifold. Therefore, the topological obstruction does not exist. The designed attitude tracking control system has a guarantee of stability in the large within a set containing all possible motions. It is able to avoid the unwinding phenomenon, and it is noise-induced chattering-free since there is no discontinuity. Furthermore, we show that the smooth attitude tracking control system has an integral input-to-state stability (iISS) guarantee in the presence of uncertainties in the moment of inertia and environmental disturbance. Simulations carried out show the effectiveness of the designed attitude tracking control system.