Glenoid pathologies are one of the main indications for shoulder arthroplasty revisions. In most cases, the glenoid bone defect is associated with insufficiency of the rotator cuff, so that only reverse total shoulder arthroplasty can be considered as arevision implant. For stable permanent fixation of the reverse glenoid component, to avoid inferior glenoid notching, and to achieve optimal function, physiological restoration of three-dimensional glenoid anatomy is necessary. In order to approach the individual glenoid pathologies in adifferentiated and optimal manner, it is important to classify the defects. Abasic distinction must be made between centric contained and eccentric uncontained defects. Combinations often occur. It is also important to consider the severity, depth, and three-dimensional orientation of the defect. Therefore, aCT analysis of the glenoid is essential preoperatively. The data obtained should serve as the basis for computer-assisted planning to determine the optimal position of the glenoid baseplate and the type and shape of the bone graft for the reconstruction. For patients with good bone quality, we recommend defect reconstruction with autologous iliac crest. The type of graft configuration and fixation and the decision between aone- and two-stage procedure depend on the type and severity of the defect. With technically correct reconstruction and proper prosthesis implantation, sufficient integration of the bone graft and durable fixation of the glenoid component can be expected with satisfactory clinical results. After bony reconstruction of the defects, repeated treatment with areverse arthroplasty is possible in the long term in the event of renewed glenoid problems.