Caries on the occlusal surface of dentition is a significant dental health problem. Among all of the teeth particularly molars and premolars have greater susceptibility to caries. Their susceptibility to caries is probably related to its occlusal morphology. Use of fissure sealant and fluoride have been shown to play an important role in reducing caries. This can be possible through converting the caries susceptible areas like pits and fissures into glazed surface which prevent bacterial colonization and makes the tooth easy to clean. Pit and fissure areas of enamel do not receive sufficient protection from topical or systemic fluorides, the reason for ineffectiveness of fluorides in the pit and fissure caries may be due to inaccessibility to these areas and due to the differences in enamel thickness. The most efficient way to prevent pit and fissure caries is by effectively sealing the fissures using resins called pit and fissure sealants.