The Hindukush Karakoram Himalaya region, an important global water unit, is the origin of ten major river basins worldwide. The Upper Indus basin, a part of this region, is a primary water source for the downstream population and is primarily fed by snow and glacier melt. Four semi-distributed conceptual hydrological models were used to understand this basin’s hydrological responses. As the observed data was unavailable, global gridded precipitation and discharge data from Global Flood Awareness System (GloFAS) were used to set up the model at the catchment outlet. Degree-Day Factor (DDF)-based snow and glacier modules are incorporated into the model structure to measure melt contribution. The results showed very good performance of all four models in Nash Sutcliffe Efficiency, greater than 0.75, with the GR4J model exhibiting superior performance. The dominance of snow and glacier melt during summer monsoon affects the peak discharge and offers insights to investigate the sub-basin scale.