This study aimed to choose appropriate strategies to reduce GHG emissions through sustainable MSW management (MSWM) in Semarang City, Indonesia. The Intergovernmental Panel on Climate Change (IPCC) guidelines was used to calculate GHG emissions from the waste sector. The factors that describe MSWM towards GHG emission mitigation were derived using a bibliometric analysis (VOSviewer). Information on current management practices and the choice of appropriate strategies was acquired using closed questionnaires answered by 20 experts and analyzed quantitatively using strengths, weaknesses, opportunities, and threats (SWOT) and quantitative strategic planning matrix (QSPM) analyses. The total GHG emissions from 2021 to 2030 can be decreased to 10.73 Gg CO2-eq/year if there is an intervention to reduce the amount of illegal waste dumping. Currently, Semarang City needs competitive strategies (ST) to achieve the reduction target based on the SWOT analysis matrix. The highest strategic priority for GHG reduction in the MSW sector is to increase the performance of the sub-district or decentralized services and its data quality management. The SWOT factors and alternative strategies resulting from this case study can be used as references for other capital cities in developing countries to determine their position in MSWM and choose appropriate strategies to achieve sustainability.