The choice of language to use as a medium of instruction across the curriculum in schools has been a contentious issue in Africa. Ghana, like many multilingual African countries, has not been spared this serious challenge of language choice. In fact, it has become a worrying issue of concern to many Ghanaians who have an interest in education. This paper provides snapshots of varied opinions on selecting a language as a medium of instruction in Ghanaian classrooms. It discusses the existing debates on the use of English language as a medium of instruction and also asserts the writer’s stance on the subject. Finally, the paper concludes by advocating the support for Ghanaian languages as a medium of instruction across the curriculum at the lower primary level.