This paper talks about the application of Hurst Index on the Ghana Stock Exchange (GSE). The aim of the paper was to find out, whether GSE daily returns have some autocorrelation (long-term dependency) and multifractality using the Hurst Index analysis. Hurst Index of daily returns of some selected stocks in the period of January 2018 to December 2018 constituting 247 trading days were computed using Rescale Range Method and the Periodogram Method. The findings show that, 91.7% of the stocks considered possess long-term dependency and only 8.3% shows multifractality. Besides, the average percentage error of the geometric fractional Brownian motion (GFBM) model was 16.68% with an efficiency accuracy of 83.32% whilst that of the geometric Brownian motion (GBM) model percentage error is 20.90% with an accuracy of 79.10%. This indicates that, the GFBM model yielded better predicting accuracy than GBM in the long-run and par predicting accuracy in the short-run.