ABSTRACT Surface urban heat island (SUHI) is a major anthropogenic alteration of Earth’s surface and can influence the local thermal environment by altering the surface energy flux balances. Researchers have paid much attention to SUHI studies in the last decades; still, its geospatial variability over a larger area is poorly understood. Detailed research is required to understand the mechanism and dynamics of SUHI along with its different driving variables. Hence in this study, we quantified the diurnal, seasonal, and interannual variation of SUHI intensity (SUHII) over 150 major Indian cities situated over different climatic zones using MODIS data from 2003 to 2018. The results reveal urban cool islands occurrence over the hot desert, hot steppe, and tropical monsoon climatic zone during daytime in both summer (−0.25 to −0.17°C) and winter (−0.33 to 0.17°C) season. In contrast, nighttime SUHII shows clear evidence of positive urban heat island irrespective of climatic region and seasonal variation of 0.48–1°C in summer and 0.46–1.32°C in winter is seen. The Mann–Kendall and Sen’s slope estimator tests are used to detect the trend of the SUHII during the study period, which suggests a higher percentage of cities showing an increasing trend of SUHII for urban heat islands than the cities of the urban cool island. Pearson’s correlation and stepwise multiple linear regression model determine the possible SUHII controlling variable over different climatic zones. During the daytime, the SUHII’s distribution is controlled by vegetation, evapotranspiration, and thermal inertia in the summer/winter season. Whereas, it is linked tightly to built-up intensity, white sky albedo, and thermal inertia in both seasons during nighttime. Overall, we found that the stepwise multiple linear regression model can explain the SUHII variance more in the daytime (>0.8) than in nighttime (>0.7, except for tropical cities) and more in understanding the SUHII behaviors for cool cities as compared to hot cities. Moreover, this study also quantifies the significant control of thermal inertia and soil moisture in understating urban heat and cool island behavior over different climatic zones.