Cultural geomorphology is a very recent discipline that studies the geomorphological component of a territory which embodies both a cultural feature of the landscape and its interactions with cultural heritage: this cultural approach concerns the dialogue and cultural integration between humanistic and scientific disciplines and can be extended to all the fields of Earth Sciences. Ophiolite rock masses strongly characterize the landscape: their greenish-black, sometimes red-brown colour; the steep profile of the slopes, which results from their greater resistance to erosion than the surrounding softer sedimentary rocks; the scarce or even absent vegetation cover. The value of ophiolites is not only related to scientific and aesthetic interests, but is also due to historical–geographical, cultural and socio-economic issues. In this research, we present the elements of cultural and landscape value related to the ophiolites of the Northern Apennines, and how these geological and geomorphological features have led to specific relationships with humankind and human geography. Indeed, ophiolites represent characteristic elements of popular culture with immediate reference to toponymy, local legends and religion. Ophiolites are also an element of great strategic importance, as they are crucial for human settlement, with specific reference to defence, and for mining and quarrying activities. The landscape of ophiolites is of great geological, geomorphological, hydrogeological and pedological interest, resulting in a high concentration of geosites, hence on the one hand the opportunity for enhancement and potential geotourism, and on the other hand the need for their protection and geoconservation.