In this study, new calculations on the excitation functions of 13C(p,n)13N, 14N(p,a)11C, 15N(p,n)15O, 16O(p,a)13N, 18O(p,n)18F, 62Ni(p,n)62Cu, 68Zn(p,n)68Ga and 72Ge(p,n)72 As reactions have been carried out in the 5–40 MeV incident proton energy range. In these calculations, the pre-equilibrium and equilibrium effects have been investigated. The pre-equilibrium calculations involve hybrid model, geometry dependent hybrid model, the cascade exciton model and full exciton model. Equilibrium effects were calculated according to Weisskopf-Ewing model. The calculated results have been compared with experimental data taken from literature.