Problem Statement and Purpose At the base of the sedimentary cover of the territory of Moldovan Pridnestrovie the deposits of the Vendian System of the Upper Proterozoic lie. As a result of drilling works during the geological exploration campaigns of the last century, the data on the stratigraphic position of layers in the section were obtained, the fossil fauna were identified, the geochemical characteristics of rocks by the method of spectral analysis were studied.The purpose of the work is to summarize data on stratigraphy, present a unified local stratigraphic scheme of the Vendian System, make a metallogenetic prognosis for different stratigraphic units of the Vendian System of Moldovan Pridnestrovie for further exploration and exploration.Data & Methods The creation of the primary data array was carried out in the training license version of the K-MINE GIS program. Information on wells (more than two hundred) from geological reports was structured and entered into a factual database consisting of a number of tables and reference files interrelated by correlation links. Geostatistical analysis was conducted with the help of the Excel editor to obtain background and abnormal values of ore components. The construction of the schematic maps of contents was made in the Surfer program.Results A local stratigraphic scheme is proposed; the Volyn Series is represented by the Kamenka Formation, the Mogilev-Podolskiy Series includes the Tatarauca Veche, Derlo, Serebriya Formations, the Avdarma Series is represented by the Causeni and Sokol Formations. The justification for the distinguishing of the formations are char acteristic faunal remains identified by E.V. Aseyeva, M.B. Burzin and L.V. Piskun, described earlier in the famous monograph of B.S. Sokolov.The values of abundances of chemical elements for layers of the Vendian System were combined due to insufficiency of spectral analysis data for the formations distinguished. Thus, for the Kamenka Formation, the values of ore components were formed by summing up the values from petrographically different rock types - diabases, sandstones and weathering crust. The values for the Olchedayev, Lomazov, Cosauti, Lyadova Layers were combined into one column and, despite the fact that they include the deposits of two formations: Tatarauca Veche and Derlo, were united in Mogilev Formation (according to the stratigraphic scheme for the Podolian Plate). Accordingly, the contents for the Bernashovka, Bronnitsa and Zinkovtsy Layers are combined into the Yaryshev Formation.As a result of this analysis, the metallogenic hydrothermal specialization of the distinguished formations has been determined. For example, the Kamenka Formation is characterized by chalcopyritic mineralization, the Mogilev and Yaryshev Formations by polymetallic mineralization. The manifestations of the sedimentary group, which led to the accumulation of industrially significant manifestations of rare-earth elements, are connected with exogenous processes.