BACKGROUND: The current challenge lies in defining the unique characteristics of compensatory and adaptive mechanisms formation, as well as the development of healthcare technologies for various forms of work in Arctic region conditions. AIM: To study associations between climate patterns and physiological responses to daily fluctuations in meteorological factors. Specifically, we aimed to investigate how these factors impact the cardiovascular system and psychophysiological well-being of workers during geological prospecting expeditions along the meridian travel between Tyumen (57° 09’ N) and Yamal (71° 11ʹ N). MATERIAL AND METHODS: A total of 115 men aged 20–40 years in mid-latitude conditions (baseline data) and during occupational relocation to the Arctic region comprised the sample. The examination included recording key indicators of the cardiovascular system (heart rate, blood pressure, mean arterial pressure, pulse pressure), ECG in standard unipolar and augmented leads, and psychophysiological assessments (evaluation of trait and state anxiety, stress diagnostics, regulation of self-control, and emotional lability). Additionally, to calculate the natural and climatic contrast of regions in Western Siberia, meteorological data and geomagnetic activity indicators were analyzed based on eight daily measurements over 12 months across 11 years using a unified system of meteorological station indicators in Tyumen and Kharasavey. RESULTS: The cardiovascular system experiences desynchronosis during meridian movement from middle latitudes to the Arctic region. This condition is influenced by the interregional climatic contrast and the differences in daily rhythm characteristics of meteorological data between the initial and final destinations. The interaction within the system of meteorological rhythms plays an important role in these variations. CONCLUSION: The established associations within the ‘meteorhythms–biorhythms’ system underscore the necessity for developing regional norms for chronophysiological parameters of a healthy individual under specific environmental and climatic conditions. It also highlights the importance of dynamic monitoring of deviations in these parameters during occupational relocations between mid-latitudes and the Arctic region across different seasons. This approach is essential for the effective monitoring of maladaptive disorders and for predicting the potential development of pathologies.