The scientific research that has become the subject of consideration in this article is related to assessment of the influence of geophysical factors on sustainable functioning of transport systems and the system analysis of their impact on the transport infrastructure at the Arctic latitudes. The research is a new direction in the field of study of operational reliability of transport systems and scientific support for development of transport infrastructure in the Russian Arctic.The paper touches upon the issues of reliability and possible failures of technical equipment under the influence of space weather, and also discusses multifaceted problems of safety and efficiency of development of transport systems considering new data on the structure and properties of the lithosphere referring to thawing of permafrost and mineral deposits. A separate section is devoted to new information on seismic activity and seismic hazard assessment in areas of operation and promising development of the transport infrastructure of the Arctic zone of the Russian Federation (AZRF).Intellectual accounting and generalisation of the obtained interdisciplinary results together with their visualisation are provided by geoinformatics methods. The paper presents also the results of adoption of modern geodatabase management systems, of the application of modern technologies of geoportals and interactive spherical visualisations for qualitative presentation of new geophysical knowledge obtained in the course of research.