Introduction. The regional geographic information system, being a tool for information and analytical support for making managerial decisions, has been widely used in almost all areas of the Federal Service in the field of consumer protection and human well-being, increasing their effectiveness and efficiency. Purpose. To analyze the effectiveness of the use of a regional geographic information system in solving the problems of the sanitary and epidemiological well-being of the region and to assess the prospects for the development of this system in the activities of the service. Material and methods. Retrospective analysis of the results of the adopted management decisions to improve the state of the environment and health of the population based on the implemented regional geographic information system. Results. The conducted retrospective analysis showed the high efficiency of using regional geoinformation systems when performing environmental and hygienic studies to assess the state of public health, environmental pollution, and in particular, to establish cause-and-effect relationships between the influence of environmental factors on public health and medical demographic indicators. Limitations. The limitation of the study is due to the inability to analyze the long-term experience of using geoinformation systems in solving the problems of sanitary and epidemiological well-being, as well as the lack of indicators of the effectiveness of their use on examples from other regions. Conclusion. The use of geoinformation technologies makes it possible for the authorities of the region to visually present information on priority hygienic and epidemiological problems in a particular administrative territory, and helps to determine the priorities for developing measures aimed at preserving the health of the population.