Aim: To investigate the effect of knee osteoarthritis (OA) compartment location on pain relief following genicular radiofrequency ablation. Materials & methods: A retrospective chart review was performed on 62 patients. Visual analog scalescores at 3 and 6months postprocedure were compared with baseline and between compartment groups. Results: Pain significantly improved for all patients at 3 and 6months (p<0.001 and p=0.005, respectively). Medial compartment OA was a significant predictor of improvement at 3months (p=0.042). Patellofemoral compartment OA was a significant predictor for a higher visual analog scale at 3months (p=0.018). Conclusion: Compartmental location of knee OA impacts pain relief following genicular radiofrequency ablation. Future protocols could target nerves based on which compartments are more affected on imaging.