Feature Selection (FS) is essential in the Internet of Things (IoT)-based Clinical Decision Support Systems (CDSS) to improve the accuracy and efficiency of the system. With the increasing number of sensors and devices used in healthcare, the volume of data generated is vast and complex. Relevant FS from this data is crucial in reducing computational overhead, improving the system’s interpretability, and enhancing the Decision-Making System (DMS) quality. FS also aids in addressing the problems of data redundancy and noise, which can negatively impact the system’s performance. FS is critical to developing practical and dependable CDSS in IoT-based healthcare sectors. This research proposes a two-phase FS model. Phase-I employs an ensemble of five Filter Methods (FM), followed by a Pearson Correlation Method (PCM). Phase-II uses the Binary Optimized Genetic Grey Wolf Optimization Algorithm (BOGGWOA) as a Wrapper Method (WM). This recommended model integrates the most valuable features of each filter. Then, it uses the Pearson Correlation Coefficient (PCC) to get rid of features that aren’t needed, a Support Vector Machine (SVM) to guess how accurate their classification will be, and BOGGWOA as the Wrapper Method (WM) to pick the most essential features with the best CA.
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