Mutation testing, a fundamental software testing technique, which is a typical way to evaluate the adequacy of a test suite. In mutation testing, a set of mutants are generated by seeding the different classes of faults into a program under test. Test data shall be generated in the way that as many mutants can be killed as possible. Thanks to numerous tools to implement mutation testing for different languages, a huge amount of mutants are normally generated even for small-sized programs. However, a large number of mutants not only leads to a high cost of mutation testing, but also make the corresponding test data generation a non-trivial task. In this paper, we make use of intelligent technologies to improve the effectiveness and efficiency of mutation testing from two perspectives. A machine learning technique, namely fuzzy clustering, is applied to categorize mutants into different clusters. Then, a multi-population genetic algorithm via individual sharing is employed to generate test data for killing the mutants in different clusters in parallel when the problem of test data generation as an optimization one. A comprehensive framework, termed as <inline-formula><tex-math notation="LaTeX">$\mathbf {FUZGENMUT}$</tex-math></inline-formula> , is thus developed to implement the proposed techniques. The experiments based on nine programs of various sizes show that fuzzy clustering can help to reduce the cost of mutation testing effectively, and that the multi-population genetic algorithm improves the efficiency of test data generation while delivering the high mutant-killing capability. The results clearly indicate that the huge potential of using intelligent technologies to enhance the efficacy and thus the practicality of mutation testing.