Pulse Generator Research Articles

Cherenkov second harmonic generation of femtosecond laser pulses in a homogeneous nonlinear crystal

In experiments on second harmonic (SH) generation (SHG), a conical structure of radiation has been observed. In the present study, a non-stationary theory of SH excitation of ultrashort laser pulses with phase modulation has been developed, which explains the properties of such a structure as Cherenkov radiation. Under phase-mismatched interactions, a maximum of the SH spectrum is observed at the Cherenkov angle, which is determined by the ratio of the SH and laser radiation phase velocities. It is shown that tightly focused laser beams are preferred to observe Cherenkov SHG. The SH spectral width depends on the group velocity mismatch and is more complicated on the excited radiation spectrum. The SH energy can be proportional to the crystal length or group delay length depending on their ratio. We also demonstrate that a complex angular distribution of spectral components (an angular chirp) appears within the SH cross-section.

63 - Battery depletion of implanted pulse generator in Sacral Neuromodulation: How do we notice it? And what could we do to ensure the continuity of care?

63 - Battery depletion of implanted pulse generator in Sacral Neuromodulation: How do we notice it? And what could we do to ensure the continuity of care?

Motor improvement of remote programming in patients with Parkinson's disease after deep brain stimulation: a 1-year follow-up.

Remote programming (RP) is an emerging technology that enables the adjustment of implantable pulse generators (IPGs) via the Internet for people with Parkinson's disease (PwPD) who have undergone deep brain stimulation (DBS). Previous studies have not comprehensively explored the effectiveness of RP in managing motor symptoms, often omitting assessments such as the rigidity and retropulsion tests during the follow-up. This study evaluates the comprehensive improvements in motor performance and the potential cost benefits of RP for PwPD with DBS. A retrospective analysis was conducted on two groups of patients-those who received RP and those who received standard programming (SP). Clinical outcomes including motor improvement, quality of life, and daily levodopa dosage were compared between the groups during a 12 (± 3)-month in-clinic follow-up. A total of 44 patients were included in the study, with 18 in the RP group and 26 in the SP group. No significant differences were observed in the frequency of programming sessions or clinical outcomes between the groups (p > 0.05). However, the RP group experienced significantly lower costs per programming session than the SP group (p < 0.05), despite patients in the former group living further from our center (p < 0.05). Our findings suggest that RP could significantly reduce the costs of programming for PwPD with DBS, especially without compromising the effectiveness of treatment across all motor symptoms in the short term.

The dependence of operating frequency of NbN Toggle Flip-flop on parameters of NbN Josephson junctions

We performed a comprehensive investigation of the relationship between the maximum operating frequency of the NbN superconducting frequency divider and the key parameters of the NbN Josephson junction (JJ). We designed a superconducting frequency divider that uses a single NbN JJ as a pulse generator, several NbN Josephson transmission lines, an NbN Toggle Flip-flop, and a load. By comparing the bias voltage V in of the pulse generator with the output voltage V out of the load, we determined if the circuit was working correctly and calculated the maximum operating frequency f max. Additionally, we employed JSICsim software for simulations to analyze the impact of key parameters of the NbN JJ, such as critical current density J c, gap voltage V g, characteristic voltage V c, quality factor Q, and specific capacitance C s, on f max. The simulation results demonstrate that f max increases with increasing J c and Q. Specifically when J c exceeds 300 kA cm−2 and Q surpasses 4, the superconducting frequency divider can achieve a f max of 1 THz. Furthermore, we successfully fabricated a superconducting frequency divider using a 10 kA cm−2 process and tested a f max of 260 GHz, with a deviation of approximately 6% from the simulation results.

Single-drive electro-optic frequency comb source on a photonic-wire-bonded thin-film lithium niobate platform.

Stable pulse and flat-top frequency comb generation are an indispensable component of many photonic applications, from ranging to communications. Lithium niobate on insulator is an excellent electro-optic (EO) platform, exhibiting high modulation efficiency and low optical loss, making it a fitting candidate for pulse generation through electro-optic modulation of continuous-wave (CW) light, a commonly utilized method for generating ultrashort pulses. Here, we demonstrate an on-chip electro-optic comb generation module on thin-film lithium niobate (TFLN) consisting of a Mach-Zehnder interferometer (MZI) amplitude modulator (AM) and a cascaded phase modulator (PM) system driven by a single-electrode drive. We show that when operated in the correct regime, the lithium niobate chips can generate frequency combs with excellent spectral power flatness. In addition, we optically package one of the pulse generator chips via photonic wire bonding. The pulses generated by the photonic-wire-bonded device are compressed to 840 fs pulse duration using an optical fiber and show extremely stable operation.

POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons.

Inactivating mutations in the melanocortin 4 receptor ( MC4R ) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of MC4RKO female mice. However, the cellular mechanisms by which MC4R regulates reproduction are unknown. Kiss1 neurons directly stimulate gonadotropin-releasing hormone (GnRH) release through two distinct populations; the Kiss1 ARH neurons, controlling GnRH pulses, and the sexually dimorphic Kiss1 AVPV/PeN neurons controlling the preovulatory LH surge. Here, we show that Mc4r expressed in Kiss1 neurons is required for fertility in females. In vivo , deletion of Mc4r from Kiss1 neurons in female mice replicates the reproductive impairments of MC4RKO mice without inducing obesity. Conversely, reinsertion of Mc4r in Kiss1 neurons of MC4R null mice restores estrous cyclicity and LH pulsatility without reducing their obese phenotype. In vitro , we dissect the specific action of MC4R on Kiss1 ARH vs Kiss1 AVPV/PeN neurons and show that MC4R activation excites Kiss1 ARH neurons through direct synaptic actions. In contrast, Kiss1 AVPV/PeN neurons are normally inhibited by MC4R activation except under elevated estradiol levels, thus facilitating the activation of Kiss1 AVPV/PeN neurons to induce the LH surge driving ovulation in females. Our findings demonstrate that POMC ARH neurons acting through MC4R, directly regulate reproductive function in females by stimulating the "pulse generator" activity of Kiss1 ARH neurons and restricting the activation of Kiss1 AVPV/PeN neurons to the time of the estradiol-dependent LH surge, and thus unveil a novel pathway of the metabolic regulation of fertility by the melanocortin system.

Simulation of the synergistic effect of multiple operation parameters on cavity soliton in nonlinear fiber resonator

All optical soliton communication is a new generation of ultra-long distance and ultra-high speed optical fiber communication technology. Optical cavity solitons (CSs), whose pulse property is unique, have shown great potentials in optical soliton communication systems. Here, a theoretical model of nonlinear fiber resonator for CS generation is proposed. The effect of pump laser and resonant cavity parameters on the CS pulse performance is detailedly investigated and deeply analysed. Furthermore, the synergistic effect of continuous wave (CW) pump laser power and pump pulse peak power, and the synergistic effect of dispersion condition, fiber nonlinear coefficient and fiber length on the generation and property of CS pulse are respectively discussed and summarized. Finally, the launch conditions and parameter variation tolerances of cavity soliton in nonlinear fiber resonant cavity have been successfully generalized. These results can provide important instruction to the experimental generation and optimization of CS pulse.

Pulsed THz radiation under ultrafast optical discharge of vacuum photodiode

In this paper, we first present an experimental demonstration of terahertz radiation pulse generation with energy up to 5 pJ under the electron emission during ultrafast optical discharge of a vacuum photodiode. We use a femtosecond optical excitation of metallic copper photocathode for the generation of ultrashort electron bunch and up to 45 kV/cm external electric field for the photo-emitted electron acceleration. Measurements of terahertz pulses energy as a function of emitted charge density, incidence angle of optical radiation and applied electric field have been provided. Spectral and polarization characteristics of generated terahertz pulses have also been studied. The proposed semi-analytical model and simulations in COMSOL Multiphysics prove the experimental data and allow for the optimization of experimental conditions aimed at flexible control of radiation parameters.Graphical

Full phonon dispersion along the stacking direction in nanoscale van der Waals materials by picosecond acoustics

Phonon dispersion in crystals determines many important material properties, but its measurement usually requires large-scale facilities and is limited to bulk samples. Here, we demonstrate the measurement of full phonon dispersion along the stacking direction in nanoscale systems by using picosecond acoustics. A heterostructure sample was prepared consisting of layers of hexagonal boron nitride (hBN) sandwiching a thin layer of black phosphorus (BP), within which a strain pulse was generated by photoexcitation and observed with an optical probe in the BP layer. The strain pulse traverses to the few nanometer thick hBN layers, where it propagates to the edge and echoes back, like acoustic waves in Newton’s cradle. The echoes returning to the BP layer provide information on the frequency-dependent time-of-flight and group velocity dispersion of the sample system. The microscopic origin of the photoinduced strain pulse generation and its propagation is revealed from first principles. Phonon frequency combs observed in the Fourier transform spectrum confirm the strain wave round trips and demonstrate the feasibility of determining group velocity dispersion through photoacoustics.

Instrumental and theoretical advancements in pulsed elution-LC × LC: Investigation of pulse parameters and application to wastewater effluent

Due to the decoupling of the first (1D) and second (2D) dimension in pulsed elution-LC × LC (PE-LC × LC), method development is more flexible and straightforward compared to fast comprehensive LC × LC where the dependencies of key parameters between the two dimensions limits its flexibility. In this study we present a method for pulse generation, which is based on a switching valve alternating between one pump that delivers the gradient and a second pump that delivers low eluotrophic strength for the pause state. Consequently, the dwell volume of the system was circumvented and 7.5, and 3.75 times shorter pulse widths could be generated at flow rates of 0.2, and 0.4 mL/min with satisfactory accuracies between programmed and observed mobile phase composition (relative deviation of 6.0 %). We investigated how key parameters including pulse width and step height, 2D gradient time and flow rate affected the peak capacity in PE-LC × LC. The conditions yielding the highest peak capacity for the PE-LC × LC- high-resolution mass spectrometry (HRMS) system were applied to a wastewater effluent sample. The results were compared to a one dimensional (1D)-LC-HRMS chromatogram. The peak capacity increased with a factor 34 from 112 for the 1D-LC run to 3770 for PE-LC × LC-HRMS after correction for undersampling. The analysis time for PE-LC × LC-HRMS was 12.1 h compared to 67.5 min for the 1D-LC-HRMS run. The purity of the mass spectra improved for PE-LC × LC-HRMS by a factor 2.6 (p-value 3.3 × 10−6) and 2.0 (p-value 2.5 × 10−3) for the low and high collision energy trace compared to the 1D-LC-HRMS analysis. Furthermore, the signal-to-noise ratio (S/N) was 4.2 times higher (range: 0.06–56.7, p-value 3.8 × 10−2) compared to the 1D-LC-HRMS separation based on 42 identified compounds. The improvements in S/N were explained by the lower peak volume obtained in the PE-LC × LC-HRMS.

Molybdenum gallium carbide coated D-shape fiber for nanosecond dark pulse generation in erbium-doped fiber laser

Molybdenum gallium carbide (Mo2Ga2C), a material belongs to MAX phase group, has garnered significant interest in a wide range of scientific field, including material science, engineering, and laser physics. It is chemically and structurally promising since it exhibits a low shear modulus, superconducting behaviour, and high mechanical stability. Here, we prepared a saturable absorber (SA) based on Mo2Ga2C coated D-shape fiber using solution casting technique. It exhibits outstanding saturable absorption of 7.2%, allowing it to generate dark pulse laser in an erbium-doped fiber laser cavity. We analyzed the laser’s performance and obtained a dark pulse with a pulse energy, peak power, and average output power of 3.9 nJ, 27.5 mW, and 7.3 mW, respectively. This foundational work may introduce a new material as an alternative SA device in fiber laser cavity.

A COMPREHENSIVE DESIGN AND SIMULATION OF QUADRUPOLE ELECTROMAGNETIC LINEAR SYSTEMS FOR PRECISE POSITIONING IN AEROSPACE

For linear motion applications, particularly in aerospace, this study outlines the creation of an essential Quadrupole Electromagnetic System (QES) as a substitute for a four-track electromagnetic launcher. The QES design is compared with a four-track system to address concerns regarding rail-armature contact sliding. In a QES, four coils provide a homogeneous electromagnetic field, resulting in a Lorentz force on the slider. The QES was designed using the three-dimensional modeling capabilities of the ANSYS software. The results of the magnetic properties show a high potential for scaling this model to various levels. Additionally, the QES power circuit was simulated using ANSYS Simplorer. The circuit uses silicon-controlled rectifiers (SCR) and a pulse-width modulation (PWM) pulse generator. A force of 4kN was achieved, and this paper presents the current and force plots in detail. The study includes finite element analysis, electromagnetic and current characteristics simulation, and monitoring of the skin and proximity effects. Performance is increased by optimizing the QES design parameters using Particle Swarm Optimization (PSO). The simulation results demonstrate the feasibility and scalability of the QES design.

Study on the partial discharge characteristics induced by the motion of cellulose particles in transformer oil

AbstractCellulose particles present a significant concern within the oil‐paper insulation of transformers, posing potential risks to insulation performance. Under the influence of the electric field, the movement of cellulose particles can compromise the transformer's insulation, leading to potential failure. An experimental platform was established to synchronously record particle motion images, partial discharge (PD) pulses, and electric voltage waveforms in oil, aiming to observe the PD characteristics resulting from particle motion under alternating current (AC) voltage and investigate the relationship between different particle motion modes, motion positions, and PD signals. The findings reveal that the phase distribution of PD signals is correlated with the particle motion mode. Specifically, the phase distribution of PD pulses during the back‐and‐forth motion mode is between 4°–94° and 182°–275°. In the suspended oscillation motion mode, the PD pulses phase is concentrated between 20°–84° and 203°–268°. The generation of PD pulses is closely linked to the particle's motion position. PD pulses occur when the particle remains on the electrode during the back‐and‐forth motion mode, generally, PD pulses rarely occur during the jumping process between the two electrodes. In the suspended oscillation motion mode, PD pulses occur when the particle moves upward, but generally do not occur during downward movement. Furthermore, the Pulse Sequence Analysis technique was used to employ the PD characteristics caused by particle motion in transformer oil. The simulation calculations of the electric field distribution for two different particle motion modes show that the particle's motion can cause distortion of the electric field distribution, leading to the generation of PD. The study of the PD characteristics at different particle motion modes and positions obtained contributes to a deeper understanding of the PD induced by cellulose particle motion under AC voltage and provides a reference for the insulation evaluation of transformers.

Non-Linear Phenomena in Voltage and Frequency Converters Supplying Non-Thermal Plasma Reactors

Atmospheric pressure cold plasmas have recently been the subject of intense research and applications for solving problems in the fields of energy, environmental engineering, and biomedicine. Non-thermal atmospheric pressure plasma sources, with dielectric barrier discharges, plasma jets, and arc discharges, are non-linear power loads. They require special power systems, which are usually designed separately for each type of plasma reactor, depending on the requirements of the plasma-chemical process, the power of the receiver, the type of process gas, the current, voltage and frequency requirements, and the efficiency of the power source. This paper presents non-linear phenomena accompanying plasma generation in the power supply plasma reactor system, such as harmonic generation, resonance, and ferroresonance of currents and voltages, and the switching of overvoltages and pulse generation. When properly applied, this can support the operation of the above-mentioned reactors by providing improved discharge ignition depending on the working gas, thus increasing the efficiency of the plasma process and improving the cooperation of the plasma-generation system with the power supply.

Rates and Predictors of Pain Reduction With Intracranial Stimulation for Intractable Pain Disorders.

Intracranial modulation paradigms, namely deep brain stimulation (DBS) and motor cortex stimulation (MCS), have been used to treat intractable pain disorders. However, treatment efficacy remains heterogeneous, and factors associated with pain reduction are not completely understood. We performed an individual patient review of pain outcomes (visual analog scale, quality-of-life measures, complications, pulse generator implant rate, cessation of stimulation) after implantation of DBS or MCS devices. We evaluated 663 patients from 36 study groups and stratified outcomes by pain etiology and implantation targets. Included studies comprised primarily retrospective cohort studies. MCS patients had a similar externalized trial success rate compared with DBS patients (86% vs 81%; P = .16), whereas patients with peripheral pain had a higher trial success rate compared with patients with central pain (88% vs 79%; P = .004). Complication rates were similar for MCS and DBS patients (12% vs 15%; P = .79). Patients with peripheral pain had lower likelihood of device cessation compared with those with central pain (5.7% vs 10%; P = .03). Of all implanted patients, mean pain reduction at last follow-up was 45.8% (95% CI: 40.3-51.2) with a 31.2% (95% CI: 12.4-50.1) improvement in quality of life. No difference was seen between MCS patients (43.8%; 95% CI: 36.7-58.2) and DBS patients (48.6%; 95% CI: 39.2-58) or central (41.5%; 95% CI: 34.8-48.2) and peripheral (46.7%; 95% CI: 38.9-54.5) etiologies. Multivariate analysis identified the anterior cingulate cortex target to be associated with worse pain reduction, while postherpetic neuralgia was a positive prognostic factor. Both DBS and MCS have similar efficacy and complication rates in the treatment of intractable pain. Patients with central pain disorders tended to have lower trial success and higher rates of device cessation. Additional prognostic factors include anterior cingulate cortex targeting and postherpetic neuralgia diagnosis. These findings underscore intracranial neurostimulation as an important modality for treatment of intractable pain disorders.

Experimental and numerical study of different mode-locking techniques in holmium fiber laser with a ring cavity.

Experimental and numerical study has been performed for three techniques of mode-locking in all-fiber Holmium laser. We have compared the fundamental repetition rate pulsed generation for mode-locking based on: nonlinear polarization evolution, polymer-free single-walled carbon nanotubes, and hybrid mode-locking. Experimental and numerical simulation results demonstrated the shortest pulse duration and maximum spectrum width for mode-locking based on the nonlinear polarization evolution: 1.3 ps, 4.2 nm and 1.3 ps, 4.1 nm, respectively. The self-starting mode in this case can vary depending on external conditions in the experiment. In Ho-doped fiber laser with polymer-free single-walled carbon nanotubes mode-locking, the small modulation depth of saturable absorption leads to a long time period of stationary single-pulse lasing development (about 104 cavity roundtrips in simulation, and ≈5 s in the experiment). Both experimental and numerical studies have indicated that a Ho-doped fiber laser with hybrid mode-locking provides optimal generation, enabling self-starting and a relatively fast transition to stable single-pulse lasing (less than 1.5 × 103 cavity roundtrips in simulation, and ≈3 s in experiment). This study presents the first employment of polymer-free single-walled carbon nanotubes for hybrid mode-locking in a Ho-doped fiber laser.

Second-harmonic generation of ultrashort pulses in refractive index linearly modulating quantum dot structure

While other works use segments of nonlinear crystal to compensate for walk-off, this work utilizes a quantum dot (QD) nanostructure for such compensation. Such nanocrystal structures allow two benefits: the high nonlinear susceptibility in these nanocrystals and the high surface density of QDs in the structure. Good results are obtained for pre-chirping and modulation parameters. The results are computed at 10 and 100 kV/cm applied electric fields. Compared to ordinary nonlinear crystals, the pulse width, intensity, and efficiency of the second harmonic (SH) pulse are all higher in QD nanocrystals, even with a low electric field applied. Higher applied fields give higher results.

Generation of attosecond gigawatt soft x-ray pulses through coherent Thomson backscattering.

Collision between relativistic electron sheets and counterpropagating laser pulses is recognized as a promising way to produce intense attosecond x rays through coherent Thomson backscattering (TBS). In a double-layer scheme, the electrons in an ultrathin solid foil are first pushed out by an intense laser driver and then interact with the laser reflected off a second foil to form a high-density relativistic electron sheet with vanishing transverse momentum. However, the repulsion between these concentrated electrons can increase the thickness of the layer, reducing both its density and subsequently the coherent TBS. Here, we present a systematic study on the evolution of the flying electron layer and find that its resulting thickness is determined by the interplay between the intrinsic space-charge expansion and the velocity compression induced by the drive laser. How the laser driver, the target areal density, the reflector, and the collision laser intensity affect the properties of the produced x rays is explored. Multidimensional particle-in-cell simulations indicate that employing this scheme in the nonlinear regime has the potential to stably produce soft x rays with several gigawatt peak power in hundreds of terawatt ultrafast laser facilities. The pulse duration can be tuned to tens of attoseconds. This compact and intense attosecond x-ray source may have broad applications in attosecond science.

Generation of double attosecond pulses with the same intensity and carrier-envelope phase

Generation of double attosecond pulses with the same intensity and carrier-envelope phase

Periodicity in the Deccan Volcanism Modulated by Plume Perturbations at the Mid‐Mantle Transition Zone

AbstractIn peninsular India, the Deccan Traps record massive, continental‐scale volcanism in a sequence of magmatic events that corresponds with the timing of mass extinction at the Cretaceous‐Paleogene boundary. Although the Deccan volcanism is linked with the Réunion hotspot, the origin of its periodic magmatic pulses is still debated. We developed a numerical model replicating the geodynamic scenario of the African superplume underneath a moving Indian plate to explore the mechanism of magmatic pulse generation during the Deccan volcanism. Our model results revealed a connection between the Réunion hotspot and the African large low shear‐wave velocity province (LLSVP), suggesting that the pulses were produced from a thermochemical plume originated in the lower mantle. The ascending plume had stagnation at 660 km due to phase changes in the transition zone, and its head eventually underwent detachment from the tail under the influence of Indian plate movement to produce sequentially four major pulses (periodicity: 5–8 Ma), each giving rise to multiple secondary magmatic pulses at a time interval of ∼0.15–0.4 Ma. This study sheds a new light on the mechanism of periodic hotspot activities from a global perspective.