Pulse Generator Research Articles

High-power idler-resonant intracavity KTA OPO driven by a dual-loss-modulated Q-switched mode-locked laser with AOM and Sb2Te3 nanosheets

By using Sb2Te3 nanosheets as saturable absorbers (SA) and an acousto-optic modulator (AOM), a laser-diode (LD) end-pumped idler-resonant KTiOAsO4 (KTA)-based intracavity optical parametric oscillator (IOPO) pumped by a dual-loss-modulated Q-switched mode-locked (QML) laser has been realized. The experimental results show that the pulse widths of the Q-switched envelope and the mode-locking pulse numbers underneath the Q-switched envelope decrease as the pump power increases. When the pump power reaches a certain value, only one mode-locking pulse underneath a Q-switched envelope exists, resulting in the generation of the subnanosecond mode-locking pulses of OPO with the repetition rate of AOM. The minimum mode-locking pulse durations of the signal and idler waves were measured to be 545 and 936 ps at an AOM frequency of 1 kHz and a diode pump power of 22.45 W, corresponding to the maximum peak powers of 648 and 185 kW, respectively. Furthermore, a set of coupled rate equations for the dual-loss-modulated QML laser-pumped intracavity idler-resonant OPO was formulated according to the Gauss distribution of intracavity photon density. The numerical simulations of these equations agree with the experimental results. These results collectively suggest the potential application of Sb2Te3 as a promising nanomaterial in the realm of optoelectronics.

Nanosecond pulse electric field treatment initiates mitochondrial apoptosis pathway by inducing mitochondrial morphological changes in myocardial cells.

As an emerging myocardial ablation technique, the mechanism of nanosecond pulse electric field (nsPEF) ablation is currently less studied. Mitochondria are one of the important membrane structure organelles in cells, participating in numerous life activities within the cell. This study aimed to explore the morphological changes of mitochondria in living cells following nsPEF treatment. Myocardial cells were treated with a self-made solid-state LTD high-voltage nanosecond pulse generator with a pulse width of 100ns for 80 times. The changes in mitochondrial membrane potential and cell apoptosis in rat myocardial cells after nsPEFs were investigated using JC-1 assay kit, apoptosis double staining assay kit, and mitochondrial fluorescence probe. The results showed that after nsPEF treatment, the mitochondrial membrane potential decreased, apoptosis increased, and the average mitochondrial area decreased from 0.48 µm2 in live myocardial cells to 0.16 µm2. The average circumference ranges from 3.17µm dropped to 1.60µm. The shape factor decreased from 1.92 to 1.41. The aspect ratio has decreased from 2.16 to 1.59. nsPEF treatment induces changes in the morphology of myocardial cell mitochondria. Based on the results of mitochondrial membrane potential and apoptosis, it can be inferred that under this equipment and parameter conditions, nsPEF treatment first causes changes in mitochondrial morphology, and then initiates the mitochondrial apoptosis pathway, which may provide experimental basis for investigating the potential mechanism of nsPEF ablation of myocardial cells.

Dual skin effect and deep heterostructure of titanium alloy subjected to high-frequency electropulsing-assisted laser shock peening

Laser shock peening, an advanced technology for severe surface plasticity peening, encounters challenges such as shallow hardened layers and surface spalling when dealing with difficult-to-machine materials. In this study, we introduced a high-frequency electropulsing-assisted laser shock peening (HFEP-LSP) technique that coupled laser shock peening with high-frequency electric pulses to achieve a significant and deeper plastic deformation layer. In the HFEP-LSP technique, we first considered the dual “skin effect”, which coupled the skin effect of high-frequency electric pulses with the “skin effect” of the mechanical effect induced by the laser shock wave. An integrated experimental platform comprising an electric pulse generator, laser shock peening equipment, and a control system was built. A >1.6 mm deep compressive residual stress layer was obtained, and the depth of the plastic deformation layer increased by 83.3 %. Furthermore, we elucidated the dual “skin effect”-induced complex heterostructure and βm phase transition. A comprehensive analysis revealed the factors contributing to the deeper strengthening layer induced by HFEP-LSP, including the compressive residual stress and plastic deformation layers. In addition, the effects of laser shock peening and HFEP-LSP on the mechanical properties were investigated. Compared to the annealed samples, the ultimate tensile strength and elongation of the HFEP-LSP-treated samples were increased by 12.3 % and 57.1 %, respectively, with a fatigue life improvement of 176.4 %. The mechanism of synergistic improvement in strength and ductility was demonstrated.

Peripheral administration of a κ-opioid receptor agonist nalfurafine inactivates gonadotropin-releasing hormone pulse generator activity in goats

Neurons co-expressing kisspeptin, neurokinin B, and dynorphin A (KNDy neurons), located in the arcuate nucleus (ARC) of the hypothalamus, are indicated to be the gonadotropin-releasing hormone (GnRH) pulse generator. Dynorphin A is reported to suppress GnRH pulse generator activity. Nalfurafine is a selective agonist of the κ-opioid receptor (KOR), a receptor for dynorphin A, clinically used as an anti-pruritic drug. This study aimed to evaluate the effects of nalfurafine on GnRH pulse generator activity and luteinizing hormone (LH) pulses using female goats. Nalfurafine (0, 2, 4, 8, or 16 μg/head) was intravenously injected into ovariectomized Shiba goats. The multiple unit activity (MUA) in the ARC area was recorded, and plasma LH concentrations were measured 2 and 48 h before and after injection, respectively. The MUA volley interval during 0–2 h after injection was significantly increased in the nalfurafine 8 and 16 μg groups compared with the vehicle group. In 0–2 h after injection, the number of LH pulses was significantly decreased in the nalfurafine 8 and 16 μg groups, and the mean and baseline LH were significantly decreased in all nalfurafine-treated groups (2, 4, 8, and 16 μg) compared with the vehicle group. These results suggest that nalfurafine inhibits the activity of the GnRH pulse generator in the ARC, thus suppressing pulsatile LH secretion. Therefore, nalfurafine could be used as a reproductive inhibitor in mammals.

High-voltage pulse generator for time-of-flight mass spectrometry in electrospray thrusters.

Electrospray thrusters exhibit diverse operational modes based on the nature of ejected particles. Time-of-flight mass spectrometry is frequently employed to analyze the composition of the plume. This study introduces a novel converter-based bipolar high-voltage pulse generator aimed at producing synchronized bipolar high-voltage pulses with controllable voltage levels and frequencies, specifically tailored for the study of electrospray thrusters. The proposed topology generates bipolar high-voltage rails from a low-voltage power source through the forward-flyback with Cockcroft-Walton voltage multiplier topology. Subsequently, fast high-voltage MOSFETs are employed to generate high-voltage pulses. This paper outlines the operational principles and design methodologies of the pulse generator. Experimental verification corroborates its operational principles and functionalities, revealing that the pulse rise and fall times consistently remain below 30ns, while the voltage can be tuned within the range of 300-1000V. An electrospray thruster was employed to conduct a thorough and practical validation of the high-voltage pulse generator. This included generating time-of-flight curves and mass spectra of the plume, resulting in precise differentiation of all particles present.

Efficient laser-driven proton acceleration from a petawatt contrast-enhanced second harmonic mixed-glass laser system

Efficient laser-driven plasma acceleration of ion beams requires precision control of the target–plasma profile, which is crucial to optimize the laser energy transfer. Along the laser propagation direction, this can be achieved by tailoring the temporal structure of the laser pulse. We show for the first time that frequency-doubling of a short pulse (hundreds-femtosecond range) petawatt-class mixed-glass laser system, which results in temporal intensity contrast enhancement, enables surface and volumetric laser–energy coupling, and the acceleration of proton beams from few-nanometer-thick foil targets. Experimentally, maximum ion energies and laser-to-proton energy conversion efficiencies were found to be both maximized at optimum laser and target conditions manifested when the normalized target density nearly equalizes the normalized laser vector potential, which is in agreement with theory and simulations. These signatures are recognized as a unique indication of the interaction between ultra-intense laser pulses with high temporal intensity contrast and ultra-thin nanometer-scale targets. Transverse modulations of accelerated proton beams in the form of bubble- and ring-like structures measured in the thinnest targets provide additional evidence of volumetric laser-driven particle acceleration regimes and transitional features in ultra-thin foil targets specific to laser–plasma interactions characterized by a high temporal intensity contrast. These results open avenues in the generation of high contrast laser pulses from short-pulse-femtosecond petawatt mixed-glass laser systems and demonstrate the feasibility of this technique for applications requiring high laser intensity contrast with high efficiency.

Time-resolved ARPES with probe energy of 6.0 eV and tunable MIR pump at 250 kHz

In this paper, we present a laser source designed specifically for time- and angle-resolved photoemission spectroscopy (TR-ARPES) investigations of light-induced electron dynamics in quantum materials. Our laser source is based on a ytterbium-doped laser that seeds an optical parametric amplifier (OPA) followed by a difference frequency generation (DFG) stage. This configuration enables the generation of tunable near-infrared and mid-infrared laser pulses (1.5 to 8 μm - 0.82 to 0.15 eV) at 250 kHz of repetition rate, serving as the pump for TR-ARPES measurements. The remaining energy of the laser is used to generate the ultraviolet 6 eV probe pulses, which prompt the material to emit photoelectrons. We demonstrate the long-term stability of the source, as well as the characterization of the beam profiles and pulse durations. Additionally, we present preliminary TR-ARPES results obtained on Bi2Te3, a prototypical 3D topological insulator. This paper illustrates the capability of our laser source to probe electronic dynamics in quantum materials.

Basaltic Pulses and Lithospheric Thinning—Plio‐Pleistocene Magmatism and Rifting in the Turkana Depression (East African Rift System)

AbstractThe East African Rift System (EARS) provides an opportunity to constrain the relationship between magmatism and plate thinning. During continental rifting, magmatism is often considered a derivative of strain accommodation—as the continental plate thins, decompression melting of the upper mantle occurs. The Turkana Depression preserves among the most extensive Cenozoic magmatic record in the rift. This magmatic record, which comprises distinct basaltic pulses followed by periods of relative magmatic quiescence, is perplexing given the lack of evidence for temporal heterogeneity in the thermo‐chemical state of the upper mantle, the nonexistence of lithospheric delamination related fast‐wave speed anomalies in the upper mantle, and the absence of evidence for sudden, accelerated divergence of Nubia and Somalia. We focus on the Pliocene Gombe Stratoid Series and show how lithospheric thinning may result in pulsed magma generation from a plume‐influenced mantle. By solving the 1D advection‐diffusion equation using rates of plate thinning broadly equivalent to those measured geodetically today we show that despite elevated mantle potential temperature, melt generation may not occur and thereby result in extended intervals of quiescence. By contrast, an increase in the rate of plate thinning can generate magma volumes that are on the order of that estimated for the parental magma of the Gombe Stratoid Series. The coincidence of large‐volume stratiform basalt events within the East African Rift shortly before the development of axial zones of tectonic‐magmatic activity suggests that the plate thinning needed to form these stratiform basalts may herald the onset of the localization of strain.

A novel racetrack Blumlein pulse forming line.

Pulse forming lines (PFL) are widely applied in high-power pulsed power generators due to their high energy density and great ability with square waveform modulation. However, the three-cylinder coaxial Blumlein line (tPFL), a commonly used PFL structure, has low energy efficiency due to the difference in impedance of the outer and inner lines. In order to increase the outer line impedance and improve the output waveform of the PFL, a racetrack Blumlein pulse forming line (r-B PFL), formed by two inner cylinders, two middle cylinders, and one outer cylinder that resembles a runway shape, is proposed in this paper. The glycerin energy storage technology and the spiral line technology were applied in the PFL. Moreover, the r-B PFL was tested experimentally after its construction, yielding a satisfactory result. The PFL structure in which multiple middle cylinders share the same outer cylinder achieves a higher outer line impedance, leading to a high energy efficiency of the PFL, which contributes to the PFL development trend toward compactness and miniaturization.

Safety and efficiency of deep brain stimulation in the elderly patients with Parkinson's disease.

Deep brain stimulation (DBS) is not routinely performed in elderly patients (≥75 years old) to date because of concerns about complications and decreased benefit. This study aimed to evaluate the safety and efficacy of DBS in elderly patients with Parkinson's disease. A retrospective analysis was performed using data from 40 elderly patients from four centers who were treated with neurosurgical robot-assisted DBS between September 2016 and December 2021. These patients were followed up for a minimum period of 2 years, with a subgroup of nine patients followed up for 5-7 years. Patient demographic characteristics, surgical information, pre- and postoperative motor scores, non-motor scores, activities of daily living, and complications were retrospectively analyzed. The mean surgical procedure duration was 1.65 ± 0.24 h, with a mean electrode implantation duration of 1.10 ± 0.23 h and a mean pulse generator implantation duration of 0.55 ± 0.07 h. The mean pneumocephalus volume, electrode fusion error, and Tao's DBS surgery scale were 16.23 ± 12.81 cm3, 0.81 ± 0.23 mm, and 77.63 ± 8.08, respectively. One patient developed a skin infection, and the device was removed. The Unified Parkinson's disease rating scale, Unified Parkinson's disease rating scale of Part III, tremor, rigidity, bradykinesia, axial, and Barthel index for activities of daily living (ADL-Barthel) scores significantly improved at the 2-year follow-up (p < 0.05). The levodopa equivalent daily dose (LEDD) was significantly reduced at the 2-year follow-up (p < 0.05). However, the Montreal cognitive assessment, Hamilton depression scale, and Hamilton anxiety scale scores did not significantly change during the 2-year follow-up (p > 0.05). Additionally, in the subgroup with a 5-year follow-up, the motor symptoms, ADL-Barthel score, and cognitive function worsened over time compared to baseline. However, there was still an improvement in motor symptoms and ADL with DBS on-stimulation compared with the off-stimulation state. The LEDD increased 5 years after surgery compared to that at baseline. Eleven patients had passed away during follow-up, the mean survival time was 38.3 ± 17.3 months after surgery, and the mean age at the time of death was 81.2 (range 75-87) years. Robot-assisted DBS surgery for the elderly patients with Parkinson's disease is accurate and safe. Motor symptoms and ADL significantly improve and patients can benefit from long-term neuromodulation, which may decrease the risk of death.

Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility.

Normal reproductive function and fertility rely on the rhythmic secretion of gonadotropin-releasing hormone (GnRH), which is driven by the hypothalamic GnRH pulse generator. A key regulator of the GnRH pulse generator is the posterodorsal subnucleus of the medial amygdala (MePD), a brain region that is involved in processing external environmental cues, including the effect of stress. However, the neuronal pathways enabling the dynamic, stress-triggered modulation of GnRH secretion remain largely unknown. Here, we employ in silico modelling in order to explore the impact of dynamic inputs on GnRH pulse generator activity. We introduce and analyse a mathematical model representing MePD neuronal circuits composed of GABAergic and glutamatergic neuronal populations, integrating it with our GnRH pulse generator model. Our analysis dissects the influence of excitatory and inhibitory MePD projections' outputs on the GnRH pulse generator's activity and reveals a functionally relevant MePD glutamatergic projection to the GnRH pulse generator, which we probe with in vivo optogenetics. Our study sheds light on how MePD neuronal dynamics affect the GnRH pulse generator activity and offers insights into stress-related dysregulation.

Low-repetition-rate near-infrared femtosecond pulse generation in a harmonically-pumped idler-resonant optical parametric oscillator

Low-repetition-rate near-infrared femtosecond pulse generation in a harmonically-pumped idler-resonant optical parametric oscillator

Predicting success using response after lead implantation with sacral neuromodulation for urgency incontinence.

Many women report inadequate symptom control after sacral neuromodulation (SNM), despite 50% reduction in urgency incontinence episodes (UUIE) after test stimulation. To determine the ideal percent UUIE reduction after test stimulation that predicts 24-month success. Using data from a multicenter SNM trial, we constructed receiver operating characteristic curves to identify an ideal threshold of percent UUIE reduction after test stimulation. We defined 24-month success as Patient Global Impression of Improvement of "very much better" to "better." We compared predictive accuracy of two models predicting success: (1) percent UUIE reduction alone and (2) with baseline characteristics. Of 149 women (median [IQR] baseline daily UUIE 4.7 [3.7, 6.0]), the ideal threshold for 24-month success was 72% (95% confidence interval 64,76%) UUIE reduction with accuracy 0.54 (0.42, 0.66), sensitivity 0.71 (0.56, 0.86) and specificity 0.27 (0.05, 0.55). The accuracy of the 50% reduction threshold was 0.60 (0.49, 0.71), sensitivity 0.95 (0.88, 1.0) and specificity 0.04 (0.0, 0.12). Percent reduction in UUIE was not better than chance in predicting 24-month success (concordance index [c-index] 0.47 [0.46, 0.62]); adding age, body mass index, diabetes mellitus and visual or hearing impairment the c-index was 0.68 (0.61, 0.78). Among women who received an internal pulse generator (IPG) due to ≥50% UUIE reduction after test stimulation, we found no ideal threshold that better predicted 24-month success. Percent reduction in UUIE after test stimulation poorly predicts 24-month success with or without clinical factors. Given this, re-evaluating how we determine who should receive an IPG is needed.

High-efficiency hundred-picosecond mid-infrared ZnGeP2 OPG/OPA system for mJ-level pulse generation

In this paper, we demonstrated a high-efficiency mid-infrared ZnGeP2 (ZGP) OPG/OPA system, operating at the mJ-level with hundred-picosecond pulses. The ZGP-based OPG configuration achieved a maximum pulse energy of 1.06 mJ at a repetition rate of 1 kHz, utilizing a pump pulse energy of 2.59 mJ and operating at a central wavelength of 3.9 μm. The system achieved a maximum slope efficiency of 51.1 %, leading to a corresponding total optical-to-optical conversion efficiency (OOCE) of 40.9 % and an output threshold as low as 0.046 GW/cm2. However, the beam quality factor M2 deteriorated, reaching values above 45. To optimize the beam quality of the mid-infrared laser, we employed an OPG/OPA tandem configuration and a double-pass OPG configuration, resulting in maximum pulse energies of 0.85 mJ and 0.36 mJ, respectively. At the highest output energy, for the OPG/OPA tandem configuration, the beam quality factors M2 were measured to be 3.2 in the x direction and 2.7 in the y direction. For the double-pass OPG configuration, the beam quality factors M2 in the two directions were measured to be 3.5 and 3.2, respectively.

AC metrology applications of the Josephson effect.

The performance of programmable voltage signals that exploit the quantum behavior of superconducting Josephson junctions continues to improve and enhance measurements in metrology, communications, and quantum control. We review advances in pulse-driven digital synthesis techniques with Josephson-junction-based devices. Quantum-based synthesis of voltage waveforms has been demonstrated at frequencies up to 3 GHz and rms amplitudes up to 4 V. Josephson pulse generators have also been used to control and characterize superconducting qubits.

Modelling of long-wave mid-infrared ultrashort pulse generation via difference frequency generation.

In this paper, a model of generating mid-infrared (MIR) ultrashort laser pulse through difference frequency generation (DFG) is established. The pulse evolution relationship among the pump, signal, and idler pulses during the DFG process, as well as the effects of crystal length, pulse energy of the pump and signal lights, pulse width, and other factors on the characteristics of the MIR pulse are explored. Furthermore, through simulations from the time domain to the frequency domain, the spectral characteristics and angular distribution of MIR were analyzed. DFG experimental data are also presented to support the model.

Fast spectroscopic imaging using extreme ultraviolet interferometry.

Extreme ultraviolet pulses as generated by high harmonic generation (HHG) are a powerful tool for both time-resolved spectroscopy and coherent diffractive imaging. However, the integration of spectroscopy and microscopy to harness the unique broadband spectra provided by HHG is hardly explored due to the challenge to decouple spectroscopic and microscopic information. Here, we present an interferometric approach to this problem that combines Fourier transform spectroscopy (FTS) with Fourier transform holography (FTH). This is made possible by the generation of phase-locked pulses using a pair of HHG sources. Crucially, in our geometry the number of interferometric measurements required is at most equal to the number of high-harmonics in the illumination, and can be further reduced by incorporating prior knowledge about the structure of the FTH sample. Compared to conventional FTS, this approach achieves over an order of magnitude increase in acquisition speed for full spectro-microscopic data, and furthermore allows high-resolution computational imaging.

Periodic spiking pulse formation in broadband nonlinear optoelectronic oscillator.

An approach to generating periodic spiking pulses in a broadband opto-electronic oscillator (OEO) without external injection is proposed and demonstrated. Through biasing the electro-optic Mach-Zehnder modulator (MZM) in the OEO cavity at its nonlinear working point, spiking pulses are excited by the self-generated chaos under the combined action of the loop filter response time and the nonlinear excitation effect. An interaction force is introduced between pulses. As a result, the pulse number in a single roundtrip duration and the temporal distribution of the generated spiking pulses can be tuned by adjusting the loop gain and the direct-current (DC) bias voltage of the MZM. Both numerical simulation and experiment are carried out to demonstrate the spiking pulse generation mechanism, where ultra-short spiking pulse trains with even and uneven temporal distribution are generated.

Passively harmonic mode-locked GHz U-band femtosecond pulse generation based on soliton self-frequency shift.

We demonstrate a GHz U-band fiber laser harnessing soliton self-frequency shift (SSFS). The seed source is a passively harmonic mode-locked (HML) fiber laser based on carbon nanotubes (CNTs) polymer film. By adjusting the pump power and polarization controller (PC) appropriately, the repetition rate can be tuned up to 1.104 GHz with a side mode suppression ratio (SMSR) of 42.5 dB. The seed source with different repetition rates can be frequency shifted from C-band to U-band in a piece of dispersion-shifted fiber (DSF) after amplification. We selected three repetition rates (457.8 MHz, 700.1 MHz, and 1104.1 MHz) and systematically studied the impact of different repetition rates on SSFS. The broad tuning range of wavelengths covering the entire U-band can be obtained by adjusting the pump power of the main amplifier. To the best of our knowledge, the demonstrated laser is the first U-band femtosecond fiber laser based on passively HML with a repetition rate over 1 GHz.

Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.

Stress impairs fertility, at least in part, via inhibition of gonadotropin secretion. Luteinizing hormone (LH) is an important gonadotropin that is released in a pulsatile pattern in males and in females throughout the majority of the ovarian cycle. Several models of stress, including acute metabolic stress, suppress LH pulses via inhibition of neurons in the arcuate nucleus of the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin (termed KNDy cells) which form the pulse generator. The mechanism for inhibition of KNDy neurons during stress, however, remains a significant outstanding question. Here, we investigated a population of catecholamine neurons in the nucleus of the solitary tract (NTS), marked by expression of the enzyme dopamine beta-hydroxylase (DBH), in female mice. First, we found that a subpopulation of DBH neurons in the NTS is activated (express c-Fos) during metabolic stress. Then, using chemogenetics, we determined that activation of these cells is sufficient to suppress LH pulses, augment corticosterone secretion, and induce sickness-like behavior. In subsequent studies, we identified evidence for suppression of KNDy cells (rather than downstream signaling pathways) and determined that the suppression of LH pulses was not dependent on the acute rise in glucocorticoids. Together these data support the hypothesis that DBH cells in the NTS are important for regulation of neuroendocrine and behavioral responses to stress.