A generalized duality quantum computer acting on mixed states (GDQC-MS) is established, which is a device consisting of a generalized quantum wave divider, a finite number of generalized quantum operations, and a generalized quantum wave combiner. Some of the interesting properties of a GDQC are explored. For example, it is proved that the divider and the combiner of a GDQC-MS are mutually dual contractions, and when the generalized quantum operations used in a GDQC-MS are contractions, the GDQC-MS is also a contraction. In that case, the loss of an input state passing through a GDQC-MS is measured and the corresponding operator of a GDQC-MS is a generalized quantum operation.
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