General Tonic Research Articles

Molecular Authentication of Radix Behen Albi (“Bahman Sefid”) Commercial Products Reveals Widespread Adulteration

Background and objectives: The roots of Centaurea behen L., (Asteraceae) known as Radix Behen Albi are used as an aphrodisiac, anti-lithiasis and general tonic. It is available as dried or powdered ...

Microwave vacuum drying behaviour on quality of dried Piper betle leaf

Herbs are mainly preserved by air drying. Air drying becomes inefficient in respect of energy consumption, drying time and dried product quality. In microwave vacuum drying, water boiling point inside product can be decreased, therefore, allowing product to be dried at a lower temperature. This will have less negative effect to the phytochemical components and indirectly to maintain the desired quality of dried material. Piper betle is one of the invaluable medicinal plants where its leaves have been used for many medicinal purposes such as ailments, infections and as a general tonic. Chief constituent of the leaves is the volatile oil. Betel oil contains two phenols: betelphenol (chavibetol) and chavico. During rainy season, betel leaf is perishable quickly. Drying is an essential approach to process betel leaf to avoid spoilage for further use with higher value addition. In our current study, the effect of microwave-vacuum drying technique on quality of P. betle leaves was evaluated. This research was conducted from 2018 to 2019 in the Scientific Laboratory of Can Tho University, Vietnam. Results clearly revealed that the raw P. betle leaves should be blanched in hot water at 100°C in 30 sec, primarily dried under convective dryer at 50°C in 4 h, deeply dried under microwave vacuum dryer in pressure of 400 mbar at 60°C within 10 min to get the final safety moisture content 8%. By this approach, the most phytochemical components such as total phenolic, flavonoid and tannin could be maintained in an effective manner. Microwave vacuum drying can save energy and preserve product quality of medicinal and aromatic plants in general and P. betle leaves in particular.

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities.

Background:Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera).

Withania somnifera (L.) Dunal (Solanaceae), known as Indian ginseng or ashwagandha, has been used in Indian Ayurveda for the treatment of a variety of disorders, such as diabetes and reproductive and nervous system disorders. It is particularly used as a general health tonic, analgesic, and sedative. As part of continuing projects to discover unique bioactive natural products from medicinal plants, phytochemical investigation of the roots of W. somnifera combined with a liquid chromatography–mass spectrometry (LC/MS)-based analysis has led to the isolation of two novel phenylpropanoid esters, Withaninsams A (1) and B (2), as an inseparable mixture, along with three known phenolic compounds (3, 4, and 6) and a pyrazole alkaloid (5). The structures of the new compounds were elucidated using a combination of spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HR-ESIMS). Withaninsams A (1) and B (2) are phenylpropanoid esters that contain a side chain, 4-methyl-1,4-pentanediol unit. To the best of our knowledge, the present study is the first to report on phenylpropanoid esters with 4-methyl-1,4-pentanediol unit. The anti-inflammatory activity of the isolated compounds (1–6) was evaluated by determining their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, where compound 3 inhibited LPS-induced NO production (IC50 = 33.3 μM) and TNF-α production, a pro-inflammatory cytokine (IC50 = 40.9 μM). The anti-inflammatory mechanism through the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments for the active compound 3, which showed decreased iNOS protein expression.

PHYTOTHERAPY FOR INFLAMMATORY DISEASES OF THE PROSTATE

The article discusses the effectiveness of herbal medicine in inflammatory diseases of the prostate. This literature review presents clinical studies of the successful use of herbal ingredients in the treatment of chronic prostatitis and relief of lower urinary tract symptoms (LUTS). Biological active substances of Urtica dioica, Cucurbita moschata, Saw palmetto (Serenoa repens), and zinc are effective in the treatment of chronic prostatitis due to anti-inflammatory, antiproliferative, antiandrogenic and antioxidant action. Phytopreparations containing these substances can be recommended as the first line of correction of LUTS in chronic forgive categories III and IV; as a general tonic for men leading a sedentary lifestyle over the age of 35 years.

Features of the diet of athletes playing sports

The article is devoted to the peculiarities of the formation of hygienic approaches to nutrition of students involved in game sports. The article analyzes the practical skills and methods of organizing the culture of nutrition of athletes of high-intensity sports. Some approaches to the rationality of the diet, taking into account modern scientific trends in the biochemical state of the organism, have been determined. Features of the diet of participants of game sports are associated with the definition of the needs of the body of athletes in energy, food and biologically active components. The issues of the use of food additives and specialized food ingredients in the practice of sports nutrition are considered. Recommendations on the development of biochemical orientation of dietary regimes were prepared depending on the level of energy expenditure of athletes, indicators of basic metabolism and body weight regulation. Such recommendations will be useful to participants of team sports and to all who are interested in the peculiarities of improving the diets of athletes. Compliance with a specially designed diet for players of game sports is especially important due to the extremely high physical activity during the competition. At the same time, before the game you can not completely abandon the usual diet and dramatically change the range of consumed foods. It is necessary to turn to a benign and simple diet that takes into account the tastes of each athlete, but with the condition that traditional products will be enriched with natural highly concentrated dietary supplements. Team sports players should pay particular attention to adaptogens, substances that are not doping-related, but have a general tonic effect on the athlete's body.

К вопросу стандартизации экстракта сухого “Солодка 7”

A promising direction for the search and development of new adaptogenic drugs of natural origin is the study of nonspecific drugs from the arsenal of Tibetan medicine, recommended for the weakened, as well as for elderly people, as a general tonic, "giving longevity and health." Based on the prescription recipe "Glyzyrhiza-7", in the indications for use: "with pain in the kidneys, lower back, limb stiffness, sudden flushes of heat in different parts of the body" developed a dry plant extract from the roots Glyzyrrhiza uralensis Fisch, wood Caragana jubata (Pall.) Poir, roots Polygonatum odoratum (Mill) Druse, roots Polygonatum humile Fisch ex Maxim, bulbs Orchis mascula L., roots Rheum rhabarbarum L., roots Rubia tinctorum L. HPLC in the dry extract revealed the presence of ten marker components whose raw material source is Rheum (deoxy-raponticin, raponticin, rapontigenin, caffeic acid), Glyzyrrhiza (likuritin, glycyrrhizinic acid), Rubia (alizarin, purpurine, ruberitrinic acid, lucidin-primverozid) The dominant compounds of the licorice 7 extract are anthraquinones, the content of which was 7.65 mg/g; stelben content 6.13 mg/g; terpenes (glycyrrhizic acid) 1.67 mg/g, flavonoids and phenol carboxylic acids account for 2.07 and 1.12 mg/g, respectively. A technique has been developed for the quantitative determination of the content of glycyrrhizic acid in the dry extract (16.5%), which can be used to standardize this object.

Cissus quadrangularis: A Natural Booster

Cissus quadrangularis L. is one of the beneficial plant blogging to the family Vitaceae mostly seema in the tropical and subtropical xeric wood. It is a flesh, cactus-like herb which is used as a food item in the variousparts of indian continents. The plant parts were also prescribed in the early Ayurvedic literature to great general tonic and analgesic diseases with certain specifications like bone fracture and healing properties. The plant is also been use in the treatment of the helminthiasis, anorexia, dyspepsia, colic, flatulence, skin diseases, leprosy, hemorrhage, epilepsy, convulsion, haemoptysis, tumors, chronic ulcers, swellings. The present review is an attempt to highlight the classification, alternatenamra, phytochemicalsqnalysis as well as the microscopic character including the various traditional uses as well as pharmacological reports on Cissus quadrangularis L are made to under stand easily.

Echium amoenum from viewpoint of Avicenna: a brief review

Echium amoenum, also named Gol-e-gavzaban in Persian, from boraginaceae family is one of the most commonly used medicinal plants, is distributed in the Northern region of Iran, as well as Europe and Mediterranean region. E. amoenum is traditionally used as herbal tea in Iranian traditional medicine for conditions such as common cold, bronchitis, stress and fatigue. It also possesses diaphoretic, diuretic and blood rectifying properties. The dried violet–blue petals of Iranian Borage are used as general tonic, cardiotonic, diaphoretic, diuretic, sedative and anti-tussive according to the Iranian Traditional Medicine (ITM). In this review article, the uses of E. amoenum as explained by Avicenna book II, Canon of medicine, book of Al-Adviah-Al-ghalbiah, and various databases of the latest scientific studies are discussed and compared. Using the experiences of old scientists in the botanical field and the properties of herbal medicines, as well as adapting new findings to old knowledge, can help us improve our understanding of prevention and treatment.It can also lead to obtain safe and cheap drugs. However, there are many common characteristics about the pharmacological properties of this plant in modern medicine and Iranian traditional medicine, but more research is needed to prove the safety and efficacy of the plant.

Plants of the GenusLavandula: From Farm to Pharmacy

The Lavandula genus, belonging to the Lamiaceae, includes 39 species, with nearly 400 registered cultivars. Lavandula are worldwide plants that occur over the Mediterranean, Europe, North Africa, southwest Asia to southeast India. Lavandula plants have been used since ancient time to flavor and preserved food, to treat diseases including wound healing, sedative, antispasmodic, microbial and viral infections. Numerous researches have described the chemical composition and the primary components of lavender oils are the monoterpenoids (linalool, linalyl acetate, 1,8-cineole, β-ocimene, terpinen-4-ol, and camphor), sesquiterpenoids (β-caryophyllene and nerolidol) and other terpenoid compounds (e.g., perillyl alcohol). The high concentrations of linalyl acetate make them attractive in perfumery, flavoring, cosmetics and soap industries. Currently, data on the antimicrobial activity of lavender plants have been scientifically confirmed. Indeed, lavender essential oils possess wide spectra of biological activities such as antispasmodic, carminative, analgesic, sedative, hypotensive, antiseptic, antimicrobial, antifungal, antidiuretic and general tonic action. In addition, clinical studies support their uses as treatment of health conditions. However, further clinical studies are necessary to define the magnitude of the efficacy, mechanisms of action, optimal doses, long-term safety, and, potential side effects of lavender plants.

Evaluation of an early twentieth century Afghan herbalist’s preparations

Mahomet Allum was a flamboyant philanthropist and herbalist who worked in South Australia in the early part of last century, whose herbal therapies generated some controversy at the time. Two of his preparations have survived to the present day, a general tonic and a treatment for liver and kidney dysfunction. Given the frequent use of pharmaceutical drugs in "tonics" at the time, toxicological analysis was undertaken at Forensic Science SA, Adelaide with liquid chromatography/quadrupole-time-of-flight mass-spectrometer (LC-QTOF MS), liquid-chromatography/ diode array detector (LC/UV) and gas chromatography/ nitrogen phosphorous- detector/mass-spectrometer (GC-NPD/MS), to look for common drugs. In addition DNA analysis was also undertaken at Trace and Environmental DNA (TrEnD) Laboratory (Curtin University) to evaluate the types of plant products used to make these remedies. The general tonic contained genera from the Triticeae (wheat) family as well as the Medicago family (includes alfalfa), possibly as fillers. Other genera found included Utrica (nettle) and Passiflora (passion flower). The preparation for liver and kidney disease also contained genera from the Medicago family as well as genera Arctostaphylos (bear berry) which has traditionally been used for the treatment of dysuria and bladder stones. No common drugs were found. Thus it appears that the two treatments prepared by Mahomet Allum contained only herbal substances and not adulterant pharmaceutical agents. The herbals identified provide an insight into herbalist practices in the early twentieth century.

A Curious Case of Hypercalcemia

Hypercalcemia is a clinical entity commonly seen on Internal Medicine inpatient units. Through standard diagnostic algorithms, the etiology of most cases can be elucidated. Brivaracetam is a novel anti-epileptic agent that binds synaptic vesicle protein 2A shown to significantly reduce seizure frequency. We describe the first case of hypercalcemia secondary to brivaracetam.
 Résumé
 L'hypercalcémie est une entité clinique couramment observée sur les unités d'hospitalisation en médecine interne. Grâce à des algorithmes de diagnostic standard, l'étiologie de la plupart des cas peut être élucidée. Brivaracetam est un nouvel agent anti-épileptique qui lie la protéine de vésicule synaptique 2A montrée pour réduire significativement la fréquence de saisie. Nous décrivons le premier cas d'hypercalcémie secondaire à Brivaracetam.
 
 

GUL-E- SURKH (Rosa damascena Mill.) AND ITS THERAPEUTIC USES DESCRIBED IN UNANI LITERATURE

Gul-e-Surkh (Rose flower) is the Persian name for the Rosa damascena Mill. In Unani system of medicine Rose flower is used for medicinal purposes. Ibn Sina considers Gul-e- Surkh as one of the best drug for liver. Rose flower in various doses form and/or in combination with many other drugs are indicated in various disease. It is commonly being used as general tonic for Lungs, Stomach, Intestine, Liver, Rectum, Kidney, Heart, and Uterus. Fresh flowers are purgative and dried one is astringent in properties. In this review article authors try to encompass the therapeutic indication of Rosa damascena Mill described in Unani literature.

Pharmacists' knowledge, attitudes, and practices towards herbal remedies in the West Bank: a cross-sectional study

BackgroundThe consumption of complementary and herbal products is increasing in many parts of the world. The purpose of this study was to investigate the knowledge and attitudes among pharmacists in West Bank towards the use of herbal products. MethodsThis cross-sectional study was done in the four largest cities in occupied Palestinian territory (Ramallah, Hebron, Bethlehem, and Nablus) between Dec 10, 2014, and March 30, 2015. Pharmacists from all specialties (community pharmacists, hospital pharmacists, and medical representatives) were invited to complete a questionnaire after giving informed consent. The responses to the questionnaire were reviewed by four research experts for face validity and piloted with 12 pharmacists to test for clarity. The questionnaire had two sections. The first section requested details of the participant's demographic information (eg, age, sex), whereas the second section included open-ended questions about the participant's behaviours towards and knowledge about use of herbal remedies. Findings350 pharmacists completed the questionnaire. The mean age of pharmacists was 32·9 years (SD 6·5). 238 (68%) pharmacists worked in community pharmacies, and their experience in practice ranged from 1–26 years. Only 133 (38%) pharmacists believed that herbal products are very effective, and 171 (49%) pharmacists believed that herbal remedies are very safe. Product packaging and product representatives were the sources of information most consulted by the pharmacists (154 [44%] for product packaging vs 89 [25%] for product representatives). General health tonic preparations were the most widely dispensed drugs, followed by cough preparations (19%). 227 (65%) pharmacists believed that herbal remedies were effective, but 175 (50%) pharacists reported concern about their safety. The knowledge about indications for herbal medicines was good, but the pharmacists' awareness of interactions and adverse effects was inadequate. 308 (88%) pharmacists believed that regulation of herbal products should be increased, whereas 262 (75%) pharmacists believed that available information about herbal products is inadequate. InterpretationMany pharmacists in West Bank believed that herbal remedies were an effective alternative therapeutic option. Continued education of herbal medicine for practicing pharmacists should be encouraged to enable pharmacists to provide competent, effective, and holistic patient care. FundingNone.

Development of composition and technology of combination drug with neurally mediated action «Memofit»

Aim. The aim of this work is to develop composition of combination drug in the form of hard-gelatin capsules «Memofit», determine technological and microbiological parameters of intermediate products and ready medicinal product and develop of manufacturing process for capsules «Memofit». Methods of the research. Investigations presented in the article were performed in accordance with the procedures described by the State Pharmacopoeia of Ukraine (SPh Ukraine). The results of the research. Necessity of the development of dietary supplement to provide special dietary properties for the purpose of regulation of functions and systems of the organism within the physiologically normal states under the nervous system dysfunction was substantiated. Results of the study of pharmaco-technological and microbiological parameters of dry extracts that are included as a compound of hard-gelatin capsules «Memofit» were presented. Optimal technological parameters for manufacturing process of capsules «Memofit» were proposed. Results of mass balance for a batch of capsules «Memofit» proved rationality of selected manufacturing process were given. Technology of manufacturing process of capsules «Memofit» was introduced into the production on the TOV “DZ “GNCLS”. Conclusions . Possibility of the development of solid formulations in the form of capsules was established based on the obtained experimental findings of the determination of pharmaco-technological and microbiological parameters of dry extracts. It was shown that capsules «Memofit» are used in dietary food ration as additional source of biologically active substances for promoting normalization of brain function and sleep, improvement of attentiveness. This preparation has general tonic properties and improves mental and physical efficiency. Manufacturing process and process flow chart for this medication was substantiated

The Effect of Alkaloidal Fraction from Annona squamosa L. against Pathogenic Bacteria with Antioxidant Activities

Background: Annona squamosa is used in different places such as India as a general tonic to enrich blood, relieve vomiting, cancer, as a vermicide, for skin complaints and also applied to wounds and ulcers. The purpose of the study was to evaluate the antibacterial and antioxidant properties from of the alkaloidal fraction of A. squamosa. Methods: Well diffusion assay, minimum inhibitory concentration and the minimum bactericidal concentration (MBC) were used to evaluate antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, MRSA and Helicobacter pylori. DPPH and SOD assays were used to evaluate antioxidant activity. LC-MS analysis was used to identify alkaloids and scanning electron microscopy studies that revealed mode of action. Results: Alkaloidal fraction of A. squamosa exhibited significant inhibition against the tested bacteria. Extracted alkaloids from the leaves of A. squamosa showed high level of antioxidant activities. LC-MS analyses of alkaloids of the plant were identified as corydine, sanjoinine, norlaureline, norcodeine, oxanalobine and aporphine in the leaves of A. squamosa. SEM analysis of the interaction of these substances with the bacteria showed morphological changes of cell wall and lysis of the targeted bacterial cells. Conclusions: It could be concluded that the alkaloids isolated from A. squamosa showed good antibacterial and antioxidant activity. The results suggest the alkaloids can be a new source of antimicrobial agents against pathogenic bacteria and antioxidant source.

Panchakola Reduces Oxidative Stress in MCF-7 Breast Cancer and HEK293 Cells

ABSTRACTA large number of studies have proven the efficacy of ayurveda in the field of health and wellness. Panchakola, an ayurvedic formulation, is a general health tonic primarily used to cure fever, inflammation, pain, indigestion, and so on. We investigated effects of panchakola on oxidative stress in MCF-7 breast cancer and human embryonic kidney 293 (HEK293) cells. This work was performed to assess the antineoplastic and free radical–scavenging potential of aqueous extract of panchakola, a polyherbal formulation, in normal and breast cancer cell lines (i.e., HEK and MCF-7, respectively) using MTT assay. Activities of antioxidant enzyme, nitric oxide scavenger, superoxide dismutase, glutathione S-transferase, and glutathione peroxidase were assessed in cell lines incubated with and without panchakola. The outcome was analyzed by spectrophotometer. The results demonstrated increased cytotoxicity in MCF-7 (IC50 16.446 μg/ml) comparable to the results obtained with standard anticancer control (curcumin) with IC50 10.265 μg/ml in MCF-7 cell line. Further, the results obtained from antioxidant assays suggested increased antioxidant activity in MCF-7 cells as compared to normal HEK cells. The results derived from this study suggested panchakola is a strong contender in the field of phytomedicines to fight cancer and free radical–related diseases.

Development of polyherbal granules and its nutritional characterization

Two poly herbal granules (AVII and SBWII) were developed utilizing the extracts of five medicinal plants on the basis of organoleptic evaluation, nutritional composition and shelf life. Five medicinal plants viz., Asparagus racemosus, Chlorophytum borivilianum, Tinospora cordifolia, Tribulus terrestris and Withania somnifera enriched with general tonic and health promoting property were selected for the formulations which were based on Aloe vera gel and soyabean whey. The nutrient analysis of the formulated granules exhibited that the carbohydrates were the major constituents in both AVII and SBWII, followed by protein and total ash. Fat contents were 0.96 and 1.18 g/100g in AVII and SBWII, respectively. The energy levels of AVII and SBWII were 378 and 377 Kcal/100g, correspondingly. Higher contents of Ca (70.20 mg/100g), Mg (85.27mg/100g) and P (61.55 mg/100g) were observed in SBWII. The trace elements revealed that, Zn and Fe content were 1.84 and 8.63mg/100g in AVII and 1.85 and 7.85mg/100g in SBWII, respectively. The retention and stability of vitamin C, total sugar, reducing sugar and non-reducing sugar for 270 days illustrated the storage life of the product in ambient condition.

New onset status epilepticus in older patients: Clinical characteristics and outcome

PurposeWe here evaluated (1) the differential characteristics of status epilepticus (SE) in older (≥60 years) compared to younger adults (18–59 years). In particular, we were interested in (2) the proportion and characteristics of new onset SE in patients with no history of epilepsy (NOSE) in older compared to younger adults, and (3) predictive parameters for clinical outcome in older subjects with NOSE. MethodsWe performed a monocentric retrospective analysis of all adult patients (≥18years) admitted with SE to our tertiary care centre over a period of 10 years (2006–2015) to evaluate clinical characteristics and short-time outcome at discharge. ResultsOne-hundred-thirty-five patients with SE were included in the study. Mean age at onset was 64 years (range 21–90), eighty-seven of the patients (64%) were older than 60 years. In 76 patients (56%), SE occurred as NOSE, sixty-seven percent of them were aged ≥60 years. There was no age-dependent predominance for NOSE. NOSE was not a relevant outcome predictor, especially regarding age-related subgroups. Older patients with NOSE had less frequently general tonic clonic SE (GTCSE; p=0.001) and were more often female (p=0.01). Regarding outcome parameters and risk factors in older patients with NOSE, unfavourable outcome was associated with infections during in-hospital treatment (0.04), extended stay in ICU (p=0.001), and generally in hospital (p<0.001). ConclusionIn our cohort, older patients represented the predominant subgroup in patients with SE. Older patients suffered more often from non-convulsive semiology and had a less favourable short-time outcome. NOSE was not a predictive outcome parameter in older patients. Data suggest that avoiding infections should have a priority because higher infection rates were associated with unfavourable outcome.

Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats

Terminalia bellirica (Gaertn.) Roxb. is a medicinal plant used for the treatment of various ailments in the traditional system of medicine like Ayurveda where it has been prescribed as a rejuvenator and general health tonic. The fruit of the plant is one of the components of the age old ayurvedic formulation-‘Triphala’. The present study evaluates curative effect of aqueous acetone extract of Terminalia bellirica fruits (AATB) against CCl4 induced oxidative stress and liver damage in an animal model. Two doses of the fruit extract (200mg/kg body weight and 400mg/kg body weight) were investigated for the beneficial effects. At the end of the treatment, liver function markers (ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin, albumin-globulin ratio) as well as hepatic oxidative stress markers (SOD, CAT, GSH) were evaluated. Treatment with AATB significantly restored the parameters towards normal level as compared to the elevated biochemical markers in the CCl4 treated animals. Reversal to normal tissue architecture was observed in histological evaluation. The results of AATB (400mg/kg) were found comparable with that of standard drug silymarin in all the parameters. The above findings suggest the therapeutic potential of the plant in alleviating hepatic oxidative stress and tissue damage, hence the traditional use of the plant in this regard stands justified.