The general education program 2018 was built in the direction of capacity development. To form and develop in students about the ability of biology subject; At the same time, contributing to the formation and development of students with major qualities and common competencies with other subjects, the primarily educational content of the Biology subject must determine the core educational content of Biology subject according to the approach to the Levels of Living Organization (LLO)- From Molecular, Cell, Organism, Population, Community Ecosystem, to Ecosphere. Those are topics that spanned from low LLO to high, reflected common characteristics of the living world such as energy metabolism and metabolism, growth and development, reproduction, induction, and evolution. But current general school biology textbooks, especially at the high school level, are compiled according to narrow specialized knowledge such as Genetics, Evolution and Ecology, that is, maintaining the opinion of single subject, so they have not fully grasped the point of view of program construction and development. The article only focused on researching and defining the content system of the topic "Reproduction" from the LLO: molecules, cells, bodies, populations to meet the general education program of biology in 2018, suggestions to overcome The compilation of the content of Biology textbooks is the current pure specialized knowledge of biology. Helping high school teachers avoid the trend of disorienting teaching that has been taking place at high schools since the renewal of the curriculum. general education program from 2006 up to now.