General Synthetic Method For Preparation Research Articles

Discovery of biomimetic transamination as a general synthetic method for preparation of fluorine-containing amines and amino acids

In this perspective review article, we describe the discovery of azomethine-azomethine isomerization of fluorinated N-benzyl-imines and its further development into one of the most convenient, scalable, and practical synthetic methods for preparation of biologically relevant fluorinated amines and amino acids. Currently referred to as 1,3-Proton Shift Reaction, this method is widely used by organic chemists for synthesis of variety fluorinated amino compounds playing important role in the design of modern pharmaceuticals and agrochemicals

General synthetic method for preparation of optically active propargyl and allylstannanes

The reaction of chiral allenyltitaniums, generated from optically active secondary propargyl phosphates and a Ti(O- i-Pr) 4/2 i-PrMgCl reagent, with trialkylstannyl chloride proceeded with a high chirality transfer of more than 93% to afford optically active secondary propargylstannanes in excellent yield, and which, in turn, were converted to optically active ( Z)-allylstannanes by reaction with Ti(O- i-Pr) 4/2 i-PrMgCl and the following hydrolysis.

Phenethylamines via Heck arylation of a new vinylamine equivalent

A new vinylamine equivalent, N-vinyloxazolone 3, has been prepared in three steps and shown to undergo Heck arylation with a variety of substrates. The Heck adducts thus obtained are then converted in one step and high yield to phenethylamine hydrochlorides. As a general synthetic method for preparation of substituted phenethylamines, use of this new reagent is shown to be superior to N-vinylphthalimide in number of steps, regiospecificity, and chemical yield

ChemInform Abstract: Reactions of the Dirhenium(II) Complexes Re2Cl4(PR3)4 with Lithium Aluminum Hydride. A Convenient Synthetic Route to the Dirhenium Octahydride Complexes Re2H8(PR3)4.

AbstractA general synthetic method for preparation of the title complexes (III), (IV) (space group P21/n, Z=2; yield 35%), and (V) (70%), which involves the reaction of triply bonded tetrachloride analogues with LiAlH4, is demonstrated for the examples (III).