Abstract
In this perspective review article, we describe the discovery of azomethine-azomethine isomerization of fluorinated N-benzyl-imines and its further development into one of the most convenient, scalable, and practical synthetic methods for preparation of biologically relevant fluorinated amines and amino acids. Currently referred to as 1,3-Proton Shift Reaction, this method is widely used by organic chemists for synthesis of variety fluorinated amino compounds playing important role in the design of modern pharmaceuticals and agrochemicals
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