In this study, it was aimed to determine the relationship between the organizational vulnerability and self-confidence levels of teachers working in public secondary schools in Ankara. The study employed the relational survey model, one of the survey models and causal comparative model. The population of the study consists of 16171 teachers working in nine central districts of Ankara, and the sample consists of 377 teachers determined by using the stratified sampling method. Research data were collected with the Organizational Vulnerability Scale and the Self-Confidence Scale. In the analysis of the data, statistics such as percentage, frequency and arithmetic mean were used to describe the situations related to the variables. In order to test whether the teachers’ organizational vulnerability and self-confidence levels vary significantly depending on the independent variables, t-test and one-way analysis of variance were used. The degree and direction of the relationship between organizational vulnerability and self-confidence were determined using the Pearson correlation coefficient, and whether self-confidence predicts organizational vulnerability was determined through multiple regression analysis. According to the analysis results, the teachers’ level of defencelessness is relatively higher than their levels of sadness, incomptence and intolerance. The teachers’ organizational vulnerability was found to not vary significantly depending on the variables of gender, school type, professional experience and union membership. However, their levels of defencelessness, sadness and general vulnerability were found to vary significantly depending on their education level and their level of incomptence was found to vary significantly depending on their branch. The teachers’ level of self-confidence was found to not vary significantly depending on the variables of gender, union membership, education level and school type; however, their levels of intrinsic and general self-confidence were found to vary significantly depending on their branch and their levels of extrinsic self-confidence and general self-confidence were found to vary significantly depending on the variable of professional experience. There is a low and negative correlation between the level of incomptence and the levels of intrinsic and extrinsic self-confidence. Self-confidence does not significantly predict organizational vulnerability.