The International Conference PhysicA.SPb was held 22-24 October 2019 in Saint-Petersburg, Russia. The Conference continues the tradition of Saint-Petersburg Seminars on Physics and Astronomy originating from mid-90s. Since then PhysicA.SPb maintains both scientific and educational quality of contributions delivered to the audience. This is the main feature of the Conference that makes it possible to combine the whole spectrum of modern Physics and Astronomy within one event.PhysicA.SPb/2019 has brought together over 450 academics from many universities and research institutes across whole Russia as well as from USA, UK, South Africa, Finland, Ukraine, Armenia, Belarus, Azerbaijan, Kazakhstan, Macedonia, Vietnam, Netherlands, Germany and France. Oral and poster presentations were combined into well-defined sections among which one should name Astronomy and Astrophysics, Optics and spectroscopy, Physics of ferroics, Nanostructured and thin-film materials, Mathematical physics and numerical methods, Devices and materials for the THz and microwave ranges, Biophysics, Optoelectronic devices, Surface phenomena, Physics and technology of energy conversion, Plasma physics, hydrodynamics and aerodynamics, Nuclear and elementary particle physics, Impurities and defects in solids, and Physics of quantum structures.This issue of the Journal of Physics: Conference Series presents the extended contributions from participants of PhysicA.SPb/2019 that were peer-reviewed by expert referees through processes administered by the Presiders of the Organising and Program Committees to the best professional and scientific standards. This was made possible by the efforts of the Sectional Editors of this Issue: Prof. Petr Arseev (Lebedev Physical Institute), Prof. Alexander Ivanchik (Ioffe Institute), Prof. Polina Ryabochkina (Ogarev Mordova State University), Prof. Yuri Kusraev (Ioffe Institute), Dr. Sergey Nekrasov (Ioffe Institute), Dr. Nikolay Bert (Ioffe Institute), Dr. Nikita Gordeev (Ioffe Institute), Dr. Alexey Popov (Ioffe Institute), Dr. Prokhor Alekseev (Ioffe Institute), Dr. Mikhail Dunaevskii (Ioffe Institute), Dr. Kirill Zaytsev (Prokhorov General Physics Institute), Dr. Alexandra Kalashnikova (Ioffe Institute) and Prof. Dmitry Khokhlov (Moscow State University).The Editors: Nikita S. Averkiev, Sergey A. Poniaev and Grigorii S. Sokolovskii