General Model Research Articles

ProkDBP: Toward more precise identification of prokaryotic DNA binding proteins.

Prokaryotic DNA binding proteins (DBPs) play pivotal roles in governing gene regulation, DNA replication, and various cellular functions. Accurate computational models for predicting prokaryotic DBPs hold immense promise in accelerating the discovery of novel proteins, fostering a deeper understanding of prokaryotic biology, and facilitating the development of therapeutics targeting for potential disease interventions. However, existing generic prediction models often exhibit lower accuracy in predicting prokaryotic DBPs. To address this gap, we introduce ProkDBP, a novel machine learning-driven computational model for prediction of prokaryotic DBPs. For prediction, a total of nine shallow learning algorithms and five deep learning models were utilized, with the shallow learning models demonstrating higher performance metrics compared to their deep learning counterparts. The light gradient boosting machine (LGBM), coupled with evolutionarily significant features selected via random forest variable importance measure (RF-VIM) yielded the highest five-fold cross-validation accuracy. The model achieved the highest auROC (0.9534) and auPRC (0.9575) among the 14 machine learning models evaluated. Additionally, ProkDBP demonstrated substantial performance with an independent dataset, exhibiting higher values of auROC (0.9332) and auPRC (0.9371). Notably, when benchmarked against several cutting-edge existing models, ProkDBP showcased superior predictive accuracy. Furthermore, to promote accessibility and usability, ProkDBP (https://iasri-sg.icar.gov.in/prokdbp/) is available as an online prediction tool, enabling free access to interested users. This tool stands as a significant contribution, enhancing the repertoire of resources for accurate and efficient prediction of prokaryotic DBPs.

A Hybrid Experimental Modelling Approach to Solar Photovoltaic Cell Temperature Prediction

Solar cell temperature is critical in the determination of solar energy generated by a solar photovoltaic power plant. High temperatures are associated with a reduction in the energy generated and hence prediction of photovoltaic cell temperature is essential in temperature mitigation and solar energy forecasting especially in commercial power plants. The present study focused on the development of a machine learning based predictive model for solar photovoltaic cell temperature prediction in commercial solar photovoltaic power plants. A physical experimental set up was developed to measure solar cell temperature under different weather and other related parameters. Satellite data were also collated for those parameters difficult to measure experimentally and were used to compliment experimental data used in this study. Satellite data used in the study were statistically transformed for each parameter used to mimic experimentally measured data. Statistical approaches were adopted to analyse the influence of both the dependent and independent variables on solar cell temperature. The analysis included multicollinearity and correlation analysis with the aid of heat maps meant to establish the relationships among the independent and dependent variables. Feature selection and dimensionality reduction was also performed to reduce the input variables and maintain relevant data in the modelling process. Parameters with a strong correlation to each other had some of them eliminated in the modelling process. A solar cell temperature predictive model based on selected weather parameters was developed using a machine learning approach (Random Forests), and parameters used were selected from the statistical analysis. The prediction accuracy of the developed model was analysed using the coefficient of determination (R2) and the mean absolute percentage error (MAPE). The results indicated a higher model performance compared to generic models used in cell temperature prediction. The prediction MAPE for the developed model was 0.83 °C while an R2 value of 0.93 was obtained which was indicative of a good model. The developed model was also comparable to other contemporary models developed to predict solar photovoltaic cell temperature. Simulations were also done to determine the annual energy generated with the incorporation of the solar cell temperature prediction model. The results revealed a 3.4% difference in the annual energy generated between a simulation which considered solar cell temperature and that which ignored the solar cell temperature. The study also revealed that this difference is even larger in monetary terms when lifetime energy generation is considered. The present study demonstrated that Random Forests, a machine learning approach to predictive modelling, can handle complex models and can provide models with a higher accuracy compared to statistical modelling approaches. The study recommends the use of solar cell predictive models to improve the accuracy of energy prediction on solar photovoltaic power plants which in turn assists in energy planning and deployment.

A multifluid model with chemically reacting components — Construction of weak solutions

We investigate the existence of weak solutions to a multi-component system, consisting of compressible chemically reacting components, coupled with the compressible Stokes equation for the velocity. Specifically, we consider the case of irreversible chemical reactions and assume a nonlinear relation between the pressure and the particular densities. These assumptions cause the additional difficulties in the mathematical analysis, due to the possible presence of vacuum.It is shown that there exists a global weak solution, satisfying the L∞ bounds for all the components. We obtain strong compactness of the sequence of densities in Lp spaces, under the assumption that all components are strictly positive. The applied method captures the properties of models of high generality, which admit an arbitrary number of components. Furthermore, the framework that we develop can handle models that contain both diffusing and non-diffusing elements.

The new physics case for beam-dump experiments with accelerated muon beams

As the field examines a future muon collider as a possible successor to the LHC, we must consider how to fully utilize not only the high-energy particle collisions, but also any lower-energy staging facilities necessary in the R&D process. An economical and efficient possibility is to use the accelerated muon beam from either the full experiment or from cooling and acceleration tests in beam-dump experiments. Beam-dump experiments are complementary to the main collider as they achieve sensitivity to very small couplings with minimal instrumentation. We demonstrate the utility of muon beam-dump experiments for new physics searches at energies from 10 GeV to 5 TeV. We find that, even at low energies like those accessible at staging or demonstrator facilities, it is possible to probe new regions of parameter space for a variety of generic BSM models, including muonphilic, leptophilic, Lμ − Lτ, and dark photon scenarios. Such experiments could therefore provide opportunities for discovery of new physics well before the completion of the full multi-TeV collider.

Aerodynamic flow field analysis of vortex interactions on multi-swept wing configurations

The underlying flow physics of vortex breakdown and vortex-vortex interactions at moderate to high angles of attack is not well understood. This lack of understanding is a challenge to the development of optimized wing designs for fighter aircraft. The goal of this study is to gain insight into the breakdown of vortices on multi-swept wing configurations. Two generic models were considered, one with a gradual vortex breakdown and one with a rapid (abrupt) breakdown. Aerodynamic forces were calculated from the US Air Force Academy (USAFA) subsonic wind tunnel to validate the experimental setup using computational fluid dynamics (CFD) and previous work. Stereoscopic particle imaging velocimetry (SPIV) was used to visualize vortex-vortex interactions, measure vortex strengths, and identify vortex breakdown locations. The measured lift and drag forces showed flow physics that agreed with previous experiments and CFD, supporting the validity of the new experimental setup. Analysis of SPIV and CFD data improved our understanding of the different types of vortex interactions observed for both models. The only difference between the models was the location of the secondary sweep angle on the chord. The C4L80 model, with a secondary sweep angle at 40% of the root chord, had a large shear layer along the leading edge, which led to vortex merging and gradual vortex breakdown at lower angles of attack than its counterpart. The C6L80 model, with a secondary sweep angle at 60% of the root chord, had no such shear layer and instead developed strong, isolated vortices that were characterized by vortex braiding and abrupt breakdown at high angles of attack. These vortices were entrained into the main vortex at the leading edge of the strake (inboard vortex), creating a balanced vortex system that enhanced lift and delayed the onset of gradual vortex breakdown seen in the C4L80 model.

Temperature compensation through kinetic regulation in biochemical oscillators

Nearly all circadian clocks maintain a period that is insensitive to temperature changes, a phenomenon known as temperature compensation (TC). Yet, it is unclear whether there is any common feature among different systems that exhibit TC. From a general timescale invariance, we show that TC relies on the existence of certain period-lengthening reactions wherein the period of the system increases strongly with the rates in these reactions. By studying several generic oscillator models, we show that this counterintuitive dependence is nonetheless a common feature of oscillators in the nonlinear (far-from-onset) regime where the oscillation can be separated into fast and slow phases. The increase of the period with the period-lengthening reaction rates occurs when the amplitude of the slow phase in the oscillation increases with these rates while the progression speed in the slow phase is controlled by other rates of the system. The positive dependence of the period on the period-lengthening rates balances its inverse dependence on other kinetic rates in the system, which gives rise to robust TC in a wide range of parameters. We demonstrate the existence of such period-lengthening reactions and their relevance for TC in all four model systems we considered. Theoretical results for a model of the Kai system are supported by experimental data. A study of the energy dissipation also shows that better TC performance requires higher energy consumption. Our study unveils a general mechanism by which a biochemical oscillator achieves TC by operating in parameter regimes far from the onset where period-lengthening reactions exist.

Deformation and Plasticity of Reinforced Concrete

Statement of the problem.Development of the model of plasticity of reinforced concrete structures is based on the intensity of the "stress-strain" relation to project tensors using transitions, as well as the coefficients of the steps of forces and axes (principal angle and strain-strain, total shear strain, etc.). Results. The dependences of plasticity modulus of concrete, transverse coefficient have been obtained. Complex functions of generalized hypotheses of deplanation of linear and angular deformations and jumps for crack formation breakaway and stiffness are constructed. It includes force flows, i.e., blocks of compressed and tensile concrete for isotropic medium (the first object), "main cracks" from fracture mechanics, functional and two-cone element for the deformation effect of reinforced concrete. The resistance of the tensile concrete is transferred to the working reinforcement using the total average longitudinal and transverse forces for the transversal-isotropic environment, including the average modulus of reinforcement and the reduced tensile concrete coefficient of the second limit state group. The special dowel effect is derived from the second level model of structural mechanics for a rebar with two pinched ends, as well as crack opening (a development of the Thomas –– author hypothesis), crack-track bank shear, and buckling. The main vector of forces in the reinforcement is characterized by two values of longitudinal and transverse displacements and the width of opening and shear of the crack-track (the third object). Conclusions. The energetic theory on the surface of the sphere and the determination of the integral of the mean square value of the tangential stresses of plasticity theory allowed to develop an alternative to the ge-neral model in the form of a paraboloid by summing the volume sectors, radius-levels from the matrix of sliding planes (including octahedral and pure shear) in concrete medium from microcracks to macrocracks.

Predicting mixed venous oxygen saturation (SvO2) impairment in COPD patients using clinical-CT radiomics data: A preliminary study.

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic airway diseases in the world. To predict the degree of mixed venous oxygen saturation (SvO2) impairment in patients with COPD by modeling using clinical-CT radiomics data and to provide reference for clinical decision-making. A total of 236 patients with COPD diagnosed by CT and clinical data at Xiangyang No. 1 People's Hospital (n= 157) and Xiangyang Central Hospital (n= 79) from June 2018 to September 2021 were retrospectively analyzed. The patients were divided into group A (SvO⩾2 62%, N= 107) and group B (SvO<2 62%, N= 129). We set up training set and test set at a ratio of 7/3 and time cutoff spot; In training set, Logistic regression was conducted to analyze the differences in general data (e.g. height, weight, systolic blood pressure), laboratory indicators (e.g. arterial oxygen saturation and pulmonary artery systolic pressure), and CT radiomics (radscore generated using chest CT texture parameters from 3D slicer software and LASSO regression) between these two groups. Further the risk factors screened by the above method were used to establish models for predicting the degree of hypoxia in COPD, conduct verification in test set and create a nomogram. Univariate analysis demonstrated that age, smoking history, drinking history, systemic systolic pressure, digestive symptoms, right ventricular diameter (RV), mean systolic pulmonary artery pressure (sPAP), cardiac index (CI), pulmonary vascular resistance (PVR), 6-min walking distance (6MWD), WHO functional classification of pulmonary hypertension (WHOPHFC), the ratio of forced expiratory volume in the first second to the forced vital capacity (FEV1%), and radscore in group B were all significantly different from those in group A (P< 0.05). Multivariate regression demonstrated that age, smoking history, digestive symptoms, 6MWD, and radscore were independent risk factors for SvO2 impairment. The combined model established based on the abovementioned indicators exhibited a good prediction effect [AUC: 0.903; 95%CI (0.858-0.937)], higher than the general clinical model [AUC: 0.760; 95%CI (0.701-0.813), P< 0.05] and laboratory examination-radiomics model [AUC: 0.868; 95%CI (0.818-0.908), P= 0.012]. The newly created nomogram may be helpful for clinical decision-making and benefit COPD patients. SvO2 is an important indicator of hypoxia in COPD, and it is highly related to age, 6MWD, and radscore. The combined model is helpful for early identification of SvO2 impairment and adjustment of COPD treatment strategies.

Deep Class-Incremental Learning From Decentralized Data.

In this article, we focus on a new and challenging decentralized machine learning paradigm in which there are continuous inflows of data to be addressed and the data are stored in multiple repositories. We initiate the study of data-decentralized class-incremental learning (DCIL) by making the following contributions. First, we formulate the DCIL problem and develop the experimental protocol. Second, we introduce a paradigm to create a basic decentralized counterpart of typical (centralized) CIL approaches, and as a result, establish a benchmark for the DCIL study. Third, we further propose a decentralized composite knowledge incremental distillation (DCID) framework to transfer knowledge from historical models and multiple local sites to the general model continually. DCID consists of three main components, namely, local CIL, collaborated knowledge distillation (KD) among local models, and aggregated KD from local models to the general one. We comprehensively investigate our DCID framework by using a different implementation of the three components. Extensive experimental results demonstrate the effectiveness of our DCID framework. The source code of the baseline methods and the proposed DCIL is available at https://github.com/Vision-Intelligence-and-Robots-Group/DCIL.

Machine Learning Memory Kernels as Closure for Non-Markovian Stochastic Processes.

Finding the dynamical law of observable quantities lies at the core of physics. Within the particular field of statistical mechanics, the generalized Langevin equation (GLE) comprises a general model for the evolution of observables covering a great deal of physical systems with many degrees of freedom and an inherently stochastic nature. Although formally exact, GLE brings its own great challenges. It depends on the complete history of the observables under scrutiny, as well as the microscopic degrees of freedom, all of which are often inaccessible. We show that these drawbacks can be overcome by adopting elements of machine learning from empirical data, in particular coupling a multilayer perceptron (MLP) with the formal structure of GLE and calibrating the MLP with the data. This yields a powerful computational tool capable of describing noisy complex systems beyond the realms of statistical mechanics. It is exemplified with a number of representative examples from different fields: from a single colloidal particle and particle chains in a thermal bath to climatology and finance, showing in all cases excellent agreement with the actual observable dynamics. The new framework offers an alternative perspective for the study of nonequilibrium processes opening also a new route for stochastic modeling.

Comparative Analysis of Generic and Fine-Tuned Large Language Models for Conversational Agent Systems

In the rapidly evolving domain of conversational agents, the integration of Large Language Models (LLMs) into Chatbot Development Platforms (CDPs) is a significant innovation. This study compares the efficacy of employing generic and fine-tuned GPT-3.5-turbo models for designing dialog flows, focusing on the intent and entity recognition crucial for dynamic conversational interactions. Two distinct approaches are introduced: a generic GPT-based system (G-GPT) leveraging the pre-trained model with complex prompts for intent and entity detection, and a fine-tuned GPT-based system (FT-GPT) employing customized models for enhanced specificity and efficiency. The evaluation encompassed the systems’ ability to accurately classify intents and recognize named entities, contrasting their adaptability, operational efficiency, and customization capabilities. The results revealed that, while the G-GPT system offers ease of deployment and versatility across various contexts, the FT-GPT system demonstrates superior precision, efficiency, and customization, although it requires initial training and dataset preparation. This research highlights the versatility of LLMs in enriching conversational features for talking assistants, from social robots to interactive chatbots. By tailoring these advanced models, the fluidity and responsiveness of conversational agents can be enhanced, making them more adaptable and effective in a variety of settings, from customer service to interactive learning environments.

AST: An OpenSim-based tool for the automatic scaling of generic musculoskeletal models

Background and objectivesThe paper introduces a tool called Automatic Scaling Tool (AST) designed for improving and expediting musculoskeletal (MSK) simulations based on generic models in OpenSim. Scaling is a crucial initial step in MSK analyses, involving the correction of virtual marker locations on a model to align with actual experimental markers. MethodsThe AST automates this process by iteratively adjusting virtual markers using scaling and inverse kinematics on a static trial. It evaluates the root mean square error (RMSE) and maximum marker error, implementing corrective actions until achieving the desired accuracy level. The tool determines whether to scale a segment with a marker-based or constant scaling factor based on checks on RMSE and segment scaling factors. ResultsTesting on three generic MSK models demonstrated that the AST significantly outperformed manual scaling by an expert operator. The RMSE for static trials was one order of magnitude lower, and for gait tasks, it was five times lower (8.5 ± 0.76 mm vs. 44.5 ± 7.5 mm). The AST consistently achieved the desired level of accuracy in less than 100 iterations, providing reliable scaled MSK models within a relatively brief timeframe, ranging from minutes to hours depending on model complexity. ConclusionsThe paper concludes that AST can greatly benefit the biomechanical community by quickly and accurately scaling generic models, a critical first step in MSK analyses. Further validation through additional experimental datasets and generic models is proposed for future tests.

3D printing of an artificial intelligence-generated patient-specific coronary artery segmentation in a support bath

Accurate segmentation of coronary artery tree and personalized 3D printing from medical images is essential for CAD diagnosis and treatment. The current literature on 3D printing relies solely on generic models created with different software or 3D coronary artery models manually segmented from medical images. Moreover, there are not many studies examining the bioprintability of a 3D model generated by artificial intelligence (AI) segmentation for complex and branched structures. In this study, deep learning algorithms with transfer learning have been employed for accurate segmentation of the coronary artery tree from medical images to generate printable segmentations. We propose a combination of deep learning and 3D printing, which accurately segments and prints complex vascular patterns in coronary arteries. Then, we performed the 3D printing of the AI-generated coronary artery segmentation for the fabrication of bifurcated hollow vascular structure. Our results indicate improved performance of segmentation with the aid of transfer learning with a Dice overlap score of 0.86 on a test set of 10 coronary tomography angiography images. Then, bifurcated regions from 3D models were printed into the Pluronic F-127 support bath using alginate + glucomannan hydrogel. We successfully fabricated the bifurcated coronary artery structures with high length and wall thickness accuracy, however, the outer diameters of the vessels and length of the bifurcation point differ from the 3D models. The extrusion of unnecessary material, primarily observed when the nozzle moves from left to the right vessel during 3D printing, can be mitigated by adjusting the nozzle speed. Moreover, the shape accuracy can also be improved by designing a multi-axis printhead that can change the printing angle in three dimensions. Thus, this study demonstrates the potential of the use of AI-segmented 3D models in the 3D printing of coronary artery structures and, when further improved, can be used for the fabrication of patient-specific vascular implants.

What makes transitional justice possible? An analysis of the Spanish case

ABSTRACT The main purpose of this research is to identify the determinants that intervene in the transitional justice choices made in general, and those made in the Spanish case in particular. The construction of a linear regression model containing 83 transitions was developed to identify the significant explanatory factors in the transitional justice choices. The analysis enabled us to place Spain at some distance from the countries considered as successful in terms of transitional justice to classify it as an exception that is not adequately explained by the general model, while also identifying the main reasons for this.

Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in-line cell culture analysis.

This study presents a novel approach for developing generic metabolic Raman calibration models for in-line cell culture analysis using glucose and lactate stock solution titration in an aqueous phase and data augmentation techniques. First, a successful set-up of the titration method was achieved by adding glucose or lactate solution at several different constant rates into the aqueous phase of a bench-top bioreactor. Subsequently, the in-line glucose and lactate concentration were calculated and interpolated based on the rate of glucose and lactate addition, enabling data augmentation and enhancing the robustness of the metabolic calibration model. Nine different combinations of spectra pretreatment, wavenumber range selection, and number of latent variables were evaluated and optimized using aqueous titration data as training set and a historical cell culture data set as validation and prediction set. Finally, Raman spectroscopy data collected from 11 historical cell culture batches (spanning four culture modes and scales ranging from 3to 200 L) were utilized to predict the corresponding glucose and lactate values. The results demonstrated a high prediction accuracy, with an average root mean square errors of predictionof 0.65 g/L for glucose, and 0.48 g/L for lactate. This innovative method establishes a generic metabolic calibration model, and its applicability can be extended to other metabolites, reducing the cost of deploying real-time cell culture monitoring using Raman spectroscopy in bioprocesses.

The Block-Correlated Pseudo Marginal Sampler for State Space Models

Pseudo Marginal Metropolis-Hastings (PMMH) is a general approach to Bayesian inference when the likelihood is intractable, but can be estimated unbiasedly. Our article develops an efficient PMMH method that scales up better to higher dimensional state vectors than previous approaches. The improvement is achieved by the following innovations. First, a novel block version of PMMH that works with multiple particle filters is proposed. Second, the trimmed mean of the unbiased likelihood estimates of the multiple particle filters is used. Third, the article develops an efficient auxiliary disturbance particle filter, which is necessary when the bootstrap disturbance filter is inefficient, but the state transition density cannot be expressed in closed form. Fourth, a novel sorting algorithm, which is as effective as previous approaches but significantly faster than them, is developed to preserve the correlation between the logs of the likelihood estimates at the current and proposed parameter values. The performance of the sampler is investigated empirically by applying it to nonlinear Dynamic Stochastic General Equilibrium models with relatively high state dimensions and with intractable state transition densities and to multivariate GARCH diffusion-driven volatility in the mean models. Although we only apply the method to state space models, the approach will be useful in a wide range of applications such as large panel data models and stochastic differential equation models with mixed effects.

A Blueprint for Multi-use Disease Modeling in Health Economics: Results from Two Expert-Panel Consultations.

The current use of health economic decision models in HTA is mostly confined to single use cases, which may be inefficient and result in little consistency over different treatment comparisons, and consequently inconsistent health policy decisions, for the same disorder. Multi-use disease models (MUDMs) (other terms: generic models, whole disease models, disease models) may offer a solution. However, much is uncertain about their definition and application. The current research aimed to develop a blueprint for the application of MUDMs. We elicited expert opinion using a two-round modified Delphi process. The panel consisted of experts and stakeholders in health economic modelling from various professional backgrounds. The first questionnaire concerned definition, terminology, potential applications, issues and recommendations for MUDMs and was based on an exploratory scoping review. In the second round, the panel members were asked to reconsider their input, based on feedback regarding first-round results, and to score issues and recommendations for priority. Finally, adding input from external advisors and policy makers in a structured way, an overview of issues and challenges was developed during two team consensus meetings. In total, 54 respondents contributed to the panel results. The term 'multi-use disease models' was proposed and agreed upon, and a definition was provided. The panel prioritized 10 potential applications (with comparing alternative policies and supporting resource allocation decisions as the top 2), while 20 issues (with model transparency and stakeholders' roles as the top 2) were identified as challenges. Opinions on potential features concerning operationalization of multi-use models were given, with 11 of these subsequently receiving high priority scores (regular updates and revalidation after updates were the top 2). MUDMs would improve on current decision support regarding cost-effectiveness information. Given feasibility challenges, this would be most relevant for diseases with multiple treatments, large burden of disease and requiring more complex models. The current overview offers policy makers a starting point to organize the development, use, and maintenance of MUDMs and to support choices concerningwhich diseases and policy decisions they will be helpful for.

Instanton NDA and applications to axion models

We present a simple set of power counting rules which allows us to easily estimate calculable instanton effects up to O\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\mathcal{O} $$\\end{document}(1) factors. We apply the resulting Instanton NDA to examine the effects of small instantons on various axion models. We confirm that mechanisms that increase the axion mass via small instantons generically also lead to an enhancement of misaligned instanton contributions to the axion potential, deepening the axion quality problem. For generic models, new sources of CP violation in the UV must be absent in order to raise the axion mass above the QCD prediction. However, we find that ZN and composite axions are UV-safe against these misalignment effects. Axion GUT models are also insensitive to UV contributions at the GUT scale, unless a very large number of extra states are introduced below this scale.

Simple Two-Message OT in the Explicit Isogeny Model

In this work we study algebraic and generic models for group actions, and extend them to the universal composability (UC) framework of Canetti (FOCS 2001). We revisit the constructions of Duman et al. (PKC 2023) integrating the type-safe model by Zhandry (Crypto 2022), adapted to the group action setting, and formally define an algebraic action model (AAM). This model restricts the power of the adversary in a similar fashion to the algebraic group model (AGM). By imposing algebraic behaviour to the adversary and environment of the UC framework, we construct the UC-AAM. Finally, we instantiate UC-AAM with isogeny-based assumptions, in particular the CSIDH action with twists, obtaining the explicit isogeny model, UC-EI; we observe that, under certain assumptions, this model is "closer" to standard UC than the UC-AGM, even though there still exists an important separation. We demonstrate the utility of our definitions by proving UC-EI security for the passive-secure oblivious transfer protocol described by Lai et al. (Eurocrypt 2021), hence providing the first concretely efficient two-message isogeny-based OT protocol in the random oracle model against malicious adversaries.

DeepHealthNet: Adolescent Obesity Prediction System Based on a Deep Learning Framework.

The global prevalence of childhood and adolescent obesity is a major concern due to its association with chronic diseases and long-term health risks. Artificial intelligence technology has been identified as a potential solution to accurately predict obesity rates and provide personalized feedback to adolescents. This study highlights the importance of early identification and prevention of obesity-related health issues. To develop effective algorithms for the prediction of obesity rates and provide personalized feedback, factors such as height, weight, waist circumference, calorie intake, physical activity levels, and other relevant health information must be taken into account. Therefore, by collecting health datasets from 321 adolescents who participated in Would You Do It! application, we proposed an adolescent obesity prediction system that provides personalized predictions and assists individuals in making informed health decisions. Our proposed deep learning framework, DeepHealthNet, effectively trains the model using data augmentation techniques, even when daily health data are limited, resulting in improved prediction accuracy (acc: 0.8842). Additionally, the study revealed variations in the prediction of the obesity rate between boys (acc: 0.9320) and girls (acc: 0.9163), allowing the identification of disparities and the determination of the optimal time to provide feedback. Statistical analysis revealed that the performance of the proposed deep learning framework was more statistically significant (p 0.001) compared to the other general models. The proposed system has the potential to effectively address childhood and adolescent obesity.