General Aspects Research Articles

New genera, species and subspecies of tessaratomine true bugs(Heteroptera: Tessaratomidae, Tessaratominae).

The genus Oukhypencha gen. nov. is described to accommodate Hypencha ophthalmica Stl, 1863, and three new species, O. clemenceae sp. nov., O. florenceae sp. nov., and O. stali sp. nov. A new subspecies, O. ophthalmica sumaterensis ssp. nov. is described from Sumatra. The genus Homoiacoris gen. nov. is created for a new species of tessaratomine true bug from Palawan Island in the Philippines, H. annemarieae sp. nov.. Habitus, male and female genitalia are illustrated. The general aspect of the new genera is similar to that of Hypencha Amyot & Serville, and the main diagnostic characters are found in the genitalia. Keys to genera of the sub-tribe Tessaratomina and species of Oukhypencha are given.

NURSING IN MEN'S HEALTH CARE IN ANDROPAUSE: literature review

Andropause, also known as late-onset male hypogonadism, is a condition related to male aging that involves a gradual decrease in testosterone levels in the body. Among the main experimental symptoms, we can list: the reduction in testosterone levels, a main characteristic of andropause. This symptom unfolds into others, such as fatigue, loss of energy, reduced libido and erectile dysfunction. The general objective of this research is to describe andropause, presenting its general and clinical aspects, in addition to demonstrating the importance of nurses in relation to treatment and health promotion. To this end, it was necessary to outline the following specific objectives: prepare a description of the general characteristics of andropause; expose considerations about male aging and the need to break taboos; demonstrate the importance of the nurse's role in the guidance and treatment of andropause. This is basic, qualitative research. As for the objectives, it is classified as descriptive and exploratory. Regarding procedures, bibliographical research was used. It was concluded that it is essential for the primary care team to plan effective nursing actions to meet the needs of men in andropause, seeking to diagnose and prevent diseases related to this phase of male life.

Myositis-associated interstitial lung disease

Introduction/ObjectiveTo review the epidemiology, general clinical aspects and diagnosis, impact on morbidity and mortality, and general treatment approaches for myositis-associated ILD. Materials and methodsThe relevant literature was reviewed. ResultsThe clinical, radiographic, and histopathological features of interstitial lung disease (ILD) in idiopathic inflammatory myopathies (IIM) are similar to idiopathic ILD. Patients with a known diagnosis of myositis require prompt clinical evaluation including the determination of myositis-associated autoantibodies. Patients possessing autoantibodies associated with ILD or those with any pulmonary symptoms should undergo a pulmonary function test and high-resolution CT (HRCT) scanning of their lungs. ConclusionDespite the lack of placebo-controlled trials, systemic glucocorticoids are considered the mainstay of initial treatment of myositis-associated ILD. Glucocorticoid-sparing agents are often concomitantly administered, particularly in patients with severe disease. The first-line conventional immunosuppressive drugs include either mycophenolate mofetil or azathioprine. If these agents fail or if the pulmonary features are severe or rapidly progressive, then more aggressive immunosuppressive or immunomodulatory therapy including cyclophosphamide, tacrolimus or cyclosporine, rituximab, IVIg, or tofacitinib can be considered. Further investigations are required to assess the role of novel therapies in the treatment of myositis-associated ILD.

Amendments to the constitution: general theoretical aspect

It suggests that improving the process of drafting constitutions and implementing constitutional support is critical to world-building efforts in the twenty-first century. We live in the days of constitutions; more than half of the nearly two hundred existing national constitutions have either been reformed or drawn up in the last thirty years. Every year, about twenty constitutional reforms are carried out and new higher laws are adopted, most of which are part of the peace-building process in countries torn by war or as a result of economic or social crises.
 It was noted that the main dilemma of Ukrainian constitutionalism of the transitional period was expressed in the conflict between the principles of Soviet legitimacy (the so-called «Soviet democracy») and plebiscite presidential power. However, this conflict has not received a final solution until today. It is most clearly manifested in the opposition of various political forces to the Constitution and finds expression in changes to it. This phenomenon is by no means completely new in history.
 Analysis of the changes to the Constitution makes it possible to draw conclusions about the general direction of these initiatives. Thus, among them there are no proposals related to the constitutional regulation of property relations and the social sphere in general (for example, land law), an extremely small number of changes related to territorial organization, organization on the new basis of local administration and self-government, administrative and judicial reform (problems of democratization of the legal system and ensuring the rights of the individual), that is, precisely those fundamental issues that form the basis of legal modernization.
 In conclusion, one should be deeply aware of all responsibility for the strategy, implementation and consequences of the political reform aimed at updating the Constitution in accordance with new realities, balancing power relations in the state, and consolidating society. This large and multifaceted work can be considered successful only when it brings real positive changes to our lives, has a beneficial effect on all spheres and in all dimensions - from the nation, the state to a specific person and a specific family. It should be assumed that changes of such a scale and depth objectively introduce elements of instability and disagreements into society and the political situation. Therefore, they must be balanced, accurately and responsibly calculated and implemented in the shortest possible time, without disturbing the general atmosphere in the state, the rhythm of its economic life. For these reasons, it is no less important that such campaigns are carried out as rarely as possible.

Benefits, risks and problems of digitalization of society:general theoretical aspect

The article analyzes the essence of digitization. It was determined that the main goal of digitization is to achieve the digital transformation of already existing and the creation of new sectors of the economy, as well as the transformation of spheres of life into new, more efficient and modern ones. Digitization is a recognized mechanism of economic growth due to the ability of technology to positively influence the efficiency, effectiveness, cost and quality of economic, public and personal activities. Its further dissemination and implementation is possible when ideas, actions, initiatives and programs related to digitization are integrated into national, regional, industry strategies and development programs. The direction of the influence of the digitization process on the country's life activities is determined. Digitization is one of the leading socio-economic trends of our time. Like any complex phenomenon, it has many facets of its manifestation. Let's name only two key ones. One of them is related to the transition of technical and economic systems from analog to digital methods of recording and broadcasting information. The second involves a phase transition to a new model of the organization of economic systems, which can tentatively be called the „digital economy". The characteristic features of the modern era - the era of digitalization - are the exponential growth of the use of intelligent devices, the speed of the Internet and the extent of its penetration into the economic and social life of society. The positive impact of digitization on social relations, the standard of living of citizens, including an increase in labor productivity, an increase in the competitiveness of enterprises, a reduction in production costs, the creation of new jobs, etc., is outlined. Risks and negative elements in the process of further implementation of digitalization in all spheres of society are highlighted, including unauthorized access to information and other threats to cyber security; mass unemployment; digital inequality. Possible regulatory measures that should be taken at the state level and help to minimize the systemic risk of digital transformation are formulated, among them are the establishment of clear rules and regulations on online content, privacy and data use, support of competition that will help stimulate investment and innovation in digital infrastructure and activities, primarily in the field of domestic digital solutions, as well as the cessation of attempts to establish foreign control in the Ukrainian segments of the digital economy and the promotion of joint investment through public-private partnerships, etc. It is emphasized that the identification of possible risks and negative consequences for the life process of society is important as for strategic forecasting and long-term planning. the impact of digitization on the further development of society is ambiguous and contradictory, as evidenced by the large number of threats it carries. It was concluded that in order to obtain positive features from the spread of digitalization, a special approach to the implementation of digital technologies in all spheres is necessary, taking into account the peculiarities of the processes taking place and the real state and peculiarities of development (educational, economic, political, social, national, cultural, etc. .) of all countries of the world, as well as mutually beneficial cooperation of countries in the spread and uniform implementation of digital technologies and the implementation of control over these processes.

Candidate Genes Associated with the Course of Epilepsy in Cerebral Palsy: Remission or Refractoriness

Epilepsy often accompanies congenital cerebral palsy (CP). Canalopathies can be the cause of congenital epilepsy. The aim of the study is to determine the influence of various determinants on the course of epilepsy. Materials and methods: The results of clinical and genetic analysis of 136 cases of cerebral palsy (CP) with epilepsy are presented. The patients were divided into groups according to the syndromes according to the classification of CP (Panteliadis and R. Korinthenberg, 2005). Epileptic syndromes were divided into three groups: focal childhood epilepsy with structural brain changes and benign epileptiform discharges (BEDC) in EEG - 41 children (30.1%), structural focal epilepsy - 37 children (27.2%), epileptic encephalopathies 58 children (42.7%). Pathogenic variants in genes were confirmed by next generation sequencing (NGS) Sanger methods of venous blood. Results. Remission was more difficult to achieve in patients with determinants of regulation of general aspects of cellular metabolism, mitochondrial function, cytoskeleton formation and function, and transport across the outer membrane. The need for polypharmacy was in the groups that regulate the function of mitochondria, the formation and functioning of the cytoskeleton, and the regulation of membrane excitability. Conclusion. Determinant analysis provides a better understanding of the mechanisms of patient responsiveness to anticonvulsant therapy. The determinant of mitochondrial function most significantly affects its effectiveness. Probably, the violation of energy metabolism in the cell neutralizes the stabilization of the neuronal membrane under the influence of anticonvulsants. The determinant of the formation and functioning of the cytoskeleton, according to our preliminary data, is associated with the formation of malformations of the brain. In this case, the refractoriness of epilepsy can be secondary and determined by the severity of structural changes in the brain.

El endotelio sano y su disfunción en el riesgo cardiovascular

The endothelium is a monolayer of flatten cells named endothelial cells that form the inner layer of the heart, blood, and lymphatic vessels. Its function is not just as a barrier, but it is a regulator of vascular permeability and tone, hemostasis, inflammation, and angiogenesis. This review is about the general aspects of vascular endothelium and endothelial dysfunction that leads to increased vascular risk. Activation and dysfunction are discussed, considering the endothelialactivation as a self-limiting process, necessary to promote inflammation and hemostasis. Endothelial dysfunction is a pathological process in which the endothelium loses its ability for self-regulation and acquires a prothrombotic and proinflammation phenotype. Endothelial dysfunction is the initial step for atherosclerosis and increased cardiovascular risk, so the main biomarkers of endothelial dysfunction are reviewed. As basic knowledge about endothelium increases, preventive or therapeutic measures can be designed as treatment or prevention the risk of its dysfunction. Key words: Healthy endothelium; activation; endothelial; endothelial dysfunction; cardiovascular risk; atherosclerosis.

Unraveling the Sexual Dimorphism of First Instar Nymphs of the Giant Stick Insect, Cladomorphus phyllinus Gray, 1835, from the Atlantic Forest, Brazil.

The first instar nymphs, both male and female, of the giant stick insect Cladomorphus phyllinus Gray, 1835 were carefully described and measured, revealing a remarkable sexual dimorphism that is considered rare among insects and is poorly explored in the order Phasmida. The studied F1 nymphs originated in captivity from eggs laid by a coupled female specimen collected in the Atlantic Forest in the vicinity of Petrópolis city, state of Rio de Janeiro, Brazil. The first instar nymphs of C. phyllinus were measured and illustrated in high-resolution photographs to show the general aspects and details of sexually dimorphic traits, making clear the phenotypic differences in the sexes. A total of 100 nymphs were kept alive until morphological sexual dimorphism was confirmed and quantified. All recently hatched first instar nymphs were separated based on the presumed male and female characteristics, i.e., the presence and absence of the suture in the metanotum in the males and females, respectively, had their sexes confirmed in 100% of the specimens as previously assigned. These results confirm this new morphological trait, which here is named "alar suture" as sex-specific in the first instar nymphs, a novelty in this stage of development of sexual differentiation. In addition, the distinct conformations of the last three abdominal sternites of both sexes were recorded.

Nanofluids and Ionic Fluids as Liquid Electrodes: An Overview on Their Properties and Potential Applications

The current review work focuses on recent developments in the exploration of electroactive nanofluids, ionanofluids, and ionic liquids acting as liquid electrodes. The nanofluids used for this purpose are composed of organic or aqueous electrolytes as base fluids with the addition of nanoparticles in pure, oxidized, or hybrid forms. On the other hand, the ionic liquids are formed by adding a solution, which can be an acid, a base, or a salt, in water. The electrochemical properties, such as electrical conductivity and capacitance, of these innovative fluids are discussed thoroughly, along with their influencing factors, such as the nature and concentration of the included nanoparticles, the type of base fluids, and the operating temperature. Moreover, this overview summarizes the fundamental applications of electroactive nanofluids, ionanofluids, and ionic liquids in various possible flow-cell configurations and electrolysis methods, along with the associated feasibility factors. Additionally, this survey of scientific papers on the matter enabled the listing and evaluation of general aspects related to the usage of electroactive nanofluids, ionanofluids, and ionic liquids. Finally, it addresses the main problems associated with such types of fluids and outlines the primary prospects for further research and utilization of electroactive nanofluids, ionanofluids, and ionic liquids in diverse scientific and technological fields.

General Considerations in Managing Non-Odontogenic Orofacial Pain

Orofacial pain is characterized as facial and mouth discomfort. The most prevalent inflammatory pain to appear in this area is dental pain. However, chronic pain illnesses, such as temporomandibular joint disorders, primary headaches (neurovascular), neuropathic pain, and idiopathic pain, can commonly mimic toothaches. Dentistry's specialty in orofacial pain focuses on diagnosing and treating persistent, complicated facial pain and oromotor disorders. This area of dentistry has grown throughout time due to the desire to comprehend better a group of patients who, for some reason, were not experiencing tooth pain issues. Orofacial discomfort has a major impact on morbidity and the use of medical services. Several illnesses can cause orofacial discomfort; diagnostic uncertainty is commonly seen in clinical practice. Due to their varying pain presentation, toothaches can resemble many chronic episodic orofacial pain syndromes, leading to many improperly prescribed antibiotic regimens and surgical treatments. Ear, nose, throat, and maxillofacial surgeons also fall victim to the misdiagnosis, making them not the only professionals to suffer from it. The orofacial region's complex diversity makes it difficult for doctors to handle non-odontogenic pain with an oral origin. The physician must be well-versed in the many pain problems affecting the orofacial area and the various alternatives accessible for their best care to provide a precise diagnosis and successful treatment. This paper focuses on the different types of pain, characteristics, assessments, investigations, and general considerations in managing non-odontogenic pain of the orofacial region. To adequately manage these patients, our profession has come to understand how important a fundamental understanding of orofacial pain is. Many improvements have been brought about by this adjustment in the approach in both clinical and educational settings. This review covers all general aspects of orofacial pain management.

Nanoclays and mineral derivates applied to pesticide water remediation

Although pesticides are vital in agroecosystems to control pests, their indiscriminate use generates innumerable environmental problems daily. Groundwater and surface water networks are the most affected environmental matrices. Since these water basins are mainly used to obtain water for human consumption, it is a challenge to find solutions to pesticide contamination. For these reasons, development of efficient and sustainable remedial technologies is key. Based on their unique properties including high surface area, recyclability, environmental friendliness, tunable surface chemistry and low cost, nanoclays and derived minerals emerged as effective adsorbents towards environmental remediation of pesticides. This study provides a comprehensive review of the use of nanoclays and mineral derivatives as adsorbents for pesticides in water. For this purpose, the characteristics of existing pesticides and general aspects of the relevant clays and minerals are discussed. Furthermore, the study provides insightful discussion on the potential application of nanoclays and their derivatives toward the mitigation of pesticide pollution in the environment. Finally, the outlook and future prospects on nanoclay implications and their environmental implementation are elucidated.

General Aspects of Bank Strategy on the Digital Transformation in North Macedonia

Abstract Change management in banking becomes more complex with a strong accent on the non-financial aspects to preserve sustainable development. The objective of this research paper is to promote powerful market interactions in the evolution of banking business models by exploiting the business model canvas method. The major banking business models in North Macedonia, identified by the method of cluster analysis in this paper were analyzed from the marketing perspective in order to present a generalized canvas of the commercial banking digital transformation aspects and strategy at the country level. The analysis was conceptualized over eight key strategic aspects. The visualization method was chosen to approach the relevance of stakeholders in the banking strategy and the value creation for society. Finally, this study concludes with the existence of substantial digitalization capacity of the banking institutions in North Macedonia, confirming its positive linkage with size, social responsibility, and international aspects.

Optimization of solid oral dosage form administration to patients with swallowing difficulties: An integrative review.

To appraise and synthesize research investigating optimizing the administration of solid oral dosage forms (SODFs) to adults with swallowing difficulties. An integrative review. An electronic search was conducted on Medical Literature Analysis and Retrieval System Online (Public Medline interface), Elsevier SciVerse Scopus and Scientific Electronic Library Online (updated February 2023). Restriction regarding the publication date was not considered for the inclusion of records. Studies addressing risks, general aspects, recommendations about patient postural adjustments, swallowing techniques, swallowing aids and aspects of concealment of SODFs were included. Fifty-three records published between 2002 and 2021 were included. The main administration risks were aspiration, asphyxia and solid oral dosage form-induced oral/oesophageal mucosal lesions. The most frequent general aspect reported was administering one oral dosage form at a time. The sitting position was the most patient postural adjustment mentioned. The most frequently reported solid oral dosage form swallowing technique was the lean-forward method for capsules. Solid oral dosage form swallowing aids cited: tongue and throat lubricant and solid oral dosage form coating device, swallowing cup and swallowing straw. The literature data on administering SODFs for adults with swallowing difficulties were appraised and synthesized. Some aspects, for example, not administering SODFs simultaneously, can make swallowing safer. Postural adjustments and solid oral dosage form swallowing aids are important to avoid administration risks. Swallowing SODFs can be easier if learned by techniques. Liquid and food are helpful as vehicles, and several of these have been listed. By optimizing the contributing factors of administering oral pharmacotherapy, the nurse can use appropriate practices to improve patient safety. Additionally, knowing and establishing the administration aspects are reasonable steps for standardizing care for patients with swallowing oral dosage form difficulties. This study addressed administering SODFs to adult patients with swallowing difficulties. The administration of SODFs to adult patients with swallowing difficulties can be optimized if only one oral dosage form at a time is administrated and if patient postural adjustments, swallowing techniques and swallowing aids are used. This investigation will impact the care of patients with swallowing difficulties. The authors declare they adhered to the relevant EQUATOR guidelines and report following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Statement. No patient or public contribution.

Cluster states and [formula omitted]-transition in the Kuramoto model with higher order interactions

We have examined the synchronization and de-synchronization transitions observable in the Kuramoto model with a standard pair-wise first harmonic interaction plus a higher order (triadic) symmetric interaction for unimodal and bimodal Gaussian distributions of the natural frequencies {ωi}. These transitions have been accurately characterized thanks to a self-consistent mean-field approach joined with extensive numerical simulations. The higher-order interactions favor the formation of two cluster states, which emerge from the incoherent regime via continuous (discontinuous) transitions for unimodal (bimodal) distributions. Fully synchronized initial states give rise to two symmetric equally populated bimodal clusters, each characterized by either positive or negative natural frequencies. These bimodal clusters are formed at an angular distance γ, which increases for decreasing pair-wise couplings until it reaches γ=π (corresponding to an anti-phase configuration), where the cluster state destabilizes via an abrupt transition: the π-transition. The uniform clusters that reform immediately after (with a smaller angle γ) are composed of oscillators with positive and negative {ωi}. For bimodal distributions we have obtained detailed phase diagrams involving all the possible dynamical states in terms of standard and novel order parameters. In particular, the clustering order parameter, here introduced, appears quite suitable to characterize the two cluster regime. As a general aspect, hysteretic (non hysteretic) synchronization transitions, mostly mediated by the emergence of standing waves, are observable for attractive (repulsive) higher-order interactions.

Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

AbstractNanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They are categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, and bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids and mesh‐like network that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, or complexion. The voids can be further sealed using suitable lipids or polymers to avoid leakage of drugs at the non‐target site, protect therapeutics from biological conditions, and control the release of therapeutics for a prolonged period. Recently, nanosponges have grasped the attention of researchers in the area of cancer by overcoming the drawbacks associated with the conventional delivery of immunotherapeutic, targeted therapeutic, and chemotherapeutic agents. Interestingly, several reports have also witnessed their potential in cancer theranostics. Owing to this supremacy, nanosponges could be an apt platform for cancer therapy and diagnosis. The current review discusses the general aspects, types, and preparation methods of nanosponges. In addition, the ambit of nanosponges in treating different types of cancer is meticulously discussed, along with detailed descriptions of their corresponding patents. Furthermore, the role of nanosponges in phototherapy and cancer theranostics are selectively canvassed.

The role of general vs pandemic-specific paranoid ideation in the use of recommended health behaviors and vaccine willingness during a worldwide pandemic: An international study in the general public

BackgroundThe public's adherence to recommended COVID-19 preventative behaviors, including vaccinations and social distancing, has been low in certain groups and has contributed to many preventable deaths worldwide. An examination of general and pandemic-specific aspects of nonclinical paranoid ideation may aid in the understanding of the public's response to the pandemic, given that it is a global threat event. MethodsA representative international sample of general adults (N = 2,510) from five international sites were recruited with stratified quota sampling. Structural equation modeling (SEM) was used to examine the relationships among general paranoid ideation, pandemic paranoid ideation (interpersonal mistrust, conspiratorial thinking, and persecutory threat), general distress (depression, anxiety), vaccine willingness, and other preventative behaviors (masking, social distancing, hygiene). ResultsAlthough general distress and paranoid ideation were associated with vaccination willingness and preventative behaviors, their effects were inconsistent or weak. Pandemic paranoid ideation showed robust direct and indirect effects that differentially predicted COVID-19 preventative behaviors, with higher interpersonal mistrust associated with higher adherence to all behaviors, higher conspiratorial thinking related to lower adherence to all behaviors, and higher persecutory threat related to higher vaccine willingness, but lower adherence to other preventative behaviors. ConclusionsExamination of pandemic-specific paranoid ideation leads to more precise prediction of the public's adherence to recommended health behaviors during the COVID-19 outbreak. This information could be used to inform intervention strategies for micro-targeting different subgroups with nonclinical paranoid thinking, as well as for improving responses to future pandemics and vaccination efforts for other common illnesses.

The NCS code of practice for the quality assurance of treatment planning systems (NCS-35)

A subcommittee of the Netherlands Commission on Radiation Dosimetry (NCS) was initiated in 2018 with the task to update and extend a previous publication (NCS-15) on the quality assurance of treatment planning systems (TPS) (Bruinvis et al 2005). The field of treatment planning has changed considerably since 2005. Whereas the focus of the previous report was more on the technical aspects of the TPS, the scope of this report is broader with a focus on a department wide implementation of the TPS. New sections about education, automated planning, information technology (IT) and updates are therefore added. Although the scope is photon therapy, large parts of this report will also apply to all other treatment modalities. This paper is a condensed version of these guidelines; the full version of the report in English is freely available from the NCS website (http://radiationdosimetry.org/ncs/publications). The paper starts with the scope of this report in relation to earlier reports on this subject. Next, general aspects of the commissioning process are addressed, like e.g. project management, education, and safety. It then focusses more on technical aspects such as beam commissioning and patient modeling, dose representation, dose calculation and (automated) plan optimisation. The final chapters deal with IT-related subjects and scripting, and the process of updating or upgrading the TPS.

Aging and oral squamous cell carcinoma development: the role of cellular senescence.

The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype (SASP), which significantly contributes to a spectrum of age-related disorders, including cancer. In the context of carcinogenesis, the SASP produced by senescent cells has been implicated in the promotion of epithelial cancers, including oral squamous cell carcinoma (OSCC), the most common form of oral cancer. Senescent cells within the tumor microenvironment release factors that amplify the growth and invasiveness of neighboring cancer cells. Senotherapeutics, including senolytics and senomorphics, emerge as promising modalities to target senescent cells and their associated inflammatory factors, thereby opening novel avenues for augmenting the efficacy of cancer treatments. Here, we review the general aspects of cellular senescence, focusing on the relation between senescence-related inflammation with cancer development. We also analyze the available evidence linking cellular senescence with OSCC, highlighting possible clinical applications.

Clamps and saddles – Part 2: Remarks on detailing and testing

AbstractThe article presents the current status of the revision of EN 1993‐1‐11 with regard to the design of saddles and clamps for ropes or for parallel wire tension components for suspended structures. The focus here is on presenting a general approach for clamps. For saddles, emphasis is on types where the slip resistance is – in addition to the component from deviation forces – increased by clamping forces, although general aspects are also covered. This part 2 deals with the geometrical requirements for clamps and in particular saddles and with the associated verification of the transverse pressure. Finally, testing is briefly discussed, with the emphasis on linking the design and the confirmation of the assumptions made thereby with the tests.

Invasive Alien Species (IAS) spread, impact and management

Invasive Alien Species (IAS) have been an increasing subject of concern with their growing speed of spread and increasing impacts on the invaded areas. The sustainability of IAS control, that is, how to make managing IAS most economical, human, and environmentally efficient is currently an issue under discussion. This review catalogs the general aspects of invasive species, from their natural spread to human-induced causes such as how it is spread through cross-sea and cross-border trades, affected by artificial constructions such as dams and reservoirs, agriculture, climate change, and deliberate introduction. The review also analyzed how IAS causes harm to the ecosystem and human community, what harm it causes, and how humans manage these invaders. Thus, providing a foundation for future research regarding the sustainability of the management of invasive alien species.