Under the background that the in-depth profile control technology is gradually applied in low-permeability fractured reservoirs, this paper regards block H of Changqing Oilfield as the research object, referring to the range of its physical parameters and field application data. Three common in-depth profile control agents (PCAs), nanosphere suspension, poly(ethylene glycol) single-phase gel particle (PEG) and cross-linked bulk gel and swelling particle (CBG-SP), are selected to investigate the compatibility between the fractured channels and the PCAs through a series of experiments. The experimental results show that the nanospheres with particle sizes of 100 nm and 300 nm have good injectivity and deep migration ability, which remains the overall core plugging rate at a high level. The residual resistance coefficient of 800 nm nanospheres decreases in a “cliff” manner along the injection direction due to the formation of blockage in the front section, resulting in a very low plugging rate in the rear section. The injection rate is an important parameter that affects the effect of PEG in the fractured channels. When the injection rate is lower than 0.1 mL/min, the plugging ability will be weakened, and if the injection rate is higher than 0.2 mL/min, the core plugging will occur. The appropriate injection rate will promote the better effect of PEG with the plugging rate > 90%. The average plugging rate of CBG-SP in fractured rock core is about 80%, and the overall control and displacement effect is good. Based on the experimental data of PCAs, the optimization criteria of slug configuration and pro-duction parameters are proposed. According to the principle “blocking, controlling and displacing”, references are provided for PCAs screening and parameters selection of field implementation.
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