A laboratory-scale anoxic-oxic sequential reactor system was seeded with acclimatized mixed microbial consortium for the treatment of common effluent treatment plant (CETP) wastewater having 7000-7400mgL(-1) of COD and 3000-3400mgL(-1) of BOD. Initially, CETP wastewater was treated under anoxic reactor at 5000mgL(-1) of MLSS concentrations, 5.26 ± 0.27kg COD m(-3)day(-1) of organic loading rate (OLR) and 36h of hydraulic retention time (HRT). Further, the effluent of anoxic reactor was treated in oxic reactor with an OLR of 6.6 ± 0.31kg COD m(-3)day(-1) and 18h HRT. Maximum color and COD removal were found to be 72 and 85% at total HRT of 2.25days under anoxic-oxic sequential reactor at 37 °C and pH 7.0. The UV-VIS, FTIR, NMR and GCMS studies showed that majority of peaks observed in untreated wastewater were either shifted or disappeared after sequential treatment. Phytotoxicity study with the seeds of Vigna radiata and Triticum aestivum showed more sensitivity toward the CETP wastewater, while the products obtained after sequential treatment does not have any inhibitory effects. The results demonstrated that the anoxic-oxic reactor fed with bacterial consortium VN11 could bring about efficient bioremediation of industrial wastewaters.