Matrix differential–difference Lax pairs play an essential role in the theory of integrable nonlinear differential–difference equations. We present sufficient conditions which allow one to simplify such a Lax pair by matrix gauge transformations. Furthermore, we describe a procedure for such a simplification and present applications of it to constructing new integrable equations connected by (non-invertible) discrete substitutions of Miura type to known equations with Lax pairs.Suppose that one has three (possibly multicomponent) equations E, E1, E2, a (Miura-type) discrete substitution from E1 to E, and a discrete substitution from E2 to E1. Then E1 and E2 can be called a modified version of E and a doubly modified version of E, respectively. We demonstrate how the above-mentioned procedure helps (in the considered examples) to construct modified and doubly modified versions of a given equation possessing a Lax pair satisfying certain conditions.The considered examples include scalar equations of Itoh–Narita–Bogoyavlensky type and 2-component equations related to the Toda lattice. We present several new integrable equations connected by new discrete substitutions of Miura type to known equations.