Event Abstract Back to Event Astrocytic structural changes correlate with overall running activities in the globus pallidus Kouko Tatsumi1*, Hiroaki Okuda1, 2, Shoko M. Takemura1, Tatsuhide Tanaka1, Ayami Ishonishi1 and Akio Wanaka1 1 Nara Medical University, Department of Anatomy & Neuroscience, Faculty of Medicine, Japan 2 Kanazawa University, Department of Functional Anatomy, Graduate School of Medical Sciences, Japan Astrocytes actively modulate neurotransmission at tripartite synapses consisted of their fine processes and neuronal synapses. Morphological changes of astrocytes are primarily attributed to such processes. During lineage-tracing studies of cells expressing Olig2, we found that Olig2-lineage mature astrocytes preferentially cluster in the globus pallidus that exerts pivotal functions in the indirect pathway of the basal ganglionic circuit. Taking advantage of membrane-targeted GAP43-EGFP, which can visualize the morphology of Olig2-lineage cells in detail, we investigated how running influenced Olig2-lineage astrocyte morphology in the globus pallidus at both the light and electron microscopic levels. Runner group mice were allowed free access to a running wheel for three weeks, and Runner-Rest group mice took an enforced three-week rest after the three-week running period. GFP immunofluorescence analyses and immunoelectron microscopy revealed that astrocytic fine processes elaborated complex arborization in the Runner mice, and reverted to simple morphology in the Runner-Rest group, which is comparable to that in the Control group. The Olig2-lineage astrocytes expressed the GABA transporter GAT-3, suggesting that they participated in inhibitory GABA transmission in the globus pallidus. The fine processes of the Olig2-lineage astrocytes underwent plastic changes that correlated with overall running activities, suggesting that they actively modulate motor functions. Keywords: Astrocytes, Globus Pallidus, Motor function, in vivo, plastic changes Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Tatsumi K, Okuda H, Takemura SM, Tanaka T, Ishonishi A and Wanaka A (2016). Astrocytic structural changes correlate with overall running activities in the globus pallidus. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00201 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Kouko Tatsumi, Nara Medical University, Department of Anatomy & Neuroscience, Faculty of Medicine, Kashihara, Nara, Japan, radha815@naramed-u.ac.jp Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kouko Tatsumi Hiroaki Okuda Shoko M Takemura Tatsuhide Tanaka Ayami Ishonishi Akio Wanaka Google Kouko Tatsumi Hiroaki Okuda Shoko M Takemura Tatsuhide Tanaka Ayami Ishonishi Akio Wanaka Google Scholar Kouko Tatsumi Hiroaki Okuda Shoko M Takemura Tatsuhide Tanaka Ayami Ishonishi Akio Wanaka PubMed Kouko Tatsumi Hiroaki Okuda Shoko M Takemura Tatsuhide Tanaka Ayami Ishonishi Akio Wanaka Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.