Abstract
Editorial: Monitoring endogenous GPCRs: lessons for drug design.
Highlights
Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France Keywords: G protein-coupled receptors, biased signaling, heteromers, chronic pain, mood disorders
G protein-coupled receptors (GPCRs) represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market
Brogi et al (2014) review novel approaches in medicinal chemistry for class A GPCRs that all aim at more efficacy with less side effects
Summary
Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France Keywords: G protein-coupled receptors, biased signaling, heteromers, chronic pain, mood disorders. Endogenous GPCRs are most often difficult to study because of a lack of tools to target them and single out their response to physiological or drug-elicited stimulations. Increasing attention is given to the concept of heteromerization that corresponds to the physical association of two receptor types resulting in new signaling properties.
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