Gastric Acid Response Research Articles

Gastric Acid Response to Massive Doses of Insulin: I. Prolonged Observations on One Individual

Summary 1.Observations of the level of gastric acidity after large and varying doses of insulin are presented as they were obtained in a single individual during a course of insulin shock treatment. Large variations were noted in acid values from day to day under apparently identical conditions. 2.No clear relationship was found between the acid response and the level of hypoglycemia, the dose of insulin or the degree of clinical insulin shock. 3.Neither massive doses of insulin nor profound hypoglycemia inhibited the parietal cell response. 4.No exhaustion of the parietal cells was noted after this prolonged stimulation.

Is gastric secretion or digestion impaired by a mixture of carbohydrate and protein in the diet?

Five people, free of any organic gastro-intestinal disease, were studied by repeated fractional gastric analysis following meals of distilled water, a pure carbohydrate, a pure protein, and mixtures of the two. Four had a normal gastric acid response and one was an achlorhydric. The studies were done in order to test the validity of the claims made that mixtures of protein and carbohydrate interfere with proper gastric digestion. The gastric secretory studies included the usual titration of acidity to Topfer’s and to phenolphthalein, hydrogen ion determinations, total chlorides, and quantitative pepsin. Gastric digestion was followed by quantitative determinations of reducing substances and amino-nitrogen in the separate fractions. More than 6,000 determinations were made on over 900 fractional specimens in the course of the studies. The results showed that:

GASTRIC MUCIN TREATMENT FOR PEPTIC ULCER

My interest in the role played by mucin in the physiology of the gastro-intestinal tract and the management of gastroduodenal ulceration was stimulated by Lim's publication, On the Relationship Between the Gastric Acid Response and the Basal Secretion of the Stomach. 1 At the lower secretory rates the concentration of mucus is undoubtedly higher than during the more active phases of gastric secretion. Many clinicians have noted a decreased secretion of mucus in patients with ulcer. 2 It is likewise noteworthy that the many patients with ulcer rarely return to a normal basal secretory state. My objective, therefore, was to feed mucin to patients with ulcer in an attempt to correct the mucin deficiency as well as to restore normal basal secretory rates. By 1929 I had prepared a gastric mucin adequate for experimental and clinical investigation. The first clinical report on the treatment of gastroduodenal ulceration with gastric mucin