Abstract Inlet Gas Void Fraction (IGVF) and rotating speed are key parameters influencing the flow characteristics of gas-liquid multiphase pumps. To explore the influence of these two factors on the flow characteristics of gas-liquid multiphase rotodynamic pumps, CFD simulations were carried out based on the Euler two-fluid model to analyze the flow characteristics in an axial-flow pump at three different rotating speeds (1450 r/min, 2200 r/min, 2950 r/min) with different IGVFs. The numerical results indicate that the pump efficiency and head are first increased and then decreased with the increase of IGVF. When the IGVF is 5%, the head and efficiency reach their maximum values. This is attributed to the minimum vorticity and turbulence kinetic energy in the impeller passage at IGVF= 5%, and the small vortex range at the hub of the guide vane, thus resulting in the stable two-phase flow state in the impeller and guide vane. At the same IGVF, with the increase of the rotating speed, the head and efficiency of the multiphase pump increase accordingly. This is closely related to the smallest vortex range formed by gas-liquid flow separation at n=2950 r/min, indicating a better flow state.