The Integral Squeeze Film Damper (ISFD) finds widespread application in various rotating machinery, such as gas turbines, turbochargers, and high-speed rotors, to dampen vibrations and improve operational stability. This study presents a comprehensive methodology to predict the fatigue life of an Integral Squeeze Film Damper (ISFD) by combining Low Cycle Fatigue (LCF), High Cycle Fatigue (HCF) test, and Finite Element (FE) simulations. An S-shaped spring specimen is designed and tested under high-cycle fatigue loading to develop the stress amplitude versus the number of the cycles curve. LCF tests are performed to obtain fatigue parameters, and a Chaboche kinematic hardening model is employed for cyclic plasticity FE simulations. FE analysis of the ISFD is conducted to establish its dynamic characteristics, aiding in identifying critical locations based on maximum von Mises stress. The integration of local stress–strain states from FE simulations with experimental fatigue parameters is carried out to predict fatigue life of ISFD. The validity of the methodology is confirmed through experimental and stress analyses, providing valuable insights for optimizing the fatigue performance of ISFD components.