We present the results of analysis of the state of greenhouse gas emissions in the oil and gas industry according to data of the last National Inventory Reports. It was shown that industry is a great source of methane leakage, responsible for 44% of total country's methane emissions in 2017. Carbon dioxide emissions from the industry make a marginal contribution to total country's carbon dioxide emissions, responsible for only 3% in 2017. It was established that the main priority for oil and gas industry is the reduction of methane emissions from natural gas activities, which is typical for gas industries in other countries. The experience of national and international programs and initiatives aimed at reducing methane emissions from oil and gas operations were used for forming the lists of measures and technologies advisable for introduction in Ukraine, concerning the hydrocarbons exploration, development, and production as well as their preparation to transportation, activities for the natural gas transportation and its underground storage, activities for the natural gas distribution and its consumption by the residential and commercial sectors. The necessity to solve in Ukraine the problem of monitoring of methane emissions and leakages in the oil and gas sector, which requires the improvement and standardization of their quantification, reporting, and verification, is mentioned separately, but this problem is not completely solved in any country of the world, which is connected with certain peculiarities of emissions sources. The article provides a comparative analysis of the results of cost calculations for the services of main pipeline transportation of natural gas with replacing existing gas-turbine gas pumping units by new gas-turbine or electric drive units. We present the external conditions for development of the oil and gas industry, for which overall estimates of greenhouse gas emissions by 2040 are calculated for two formed scenarios – with and without measures for emission reduction.