AIM: This in vitro study was designed to evaluate the shear bond strength after bonding between porcelain laminate veneers and the tooth surface using different etching methods METHODS: Thirty freshly extracted maxillary premolars were used and prepared for receiving Enamic laminate veneers. Specimens were divided into two groups (n = 15), according to the surface treatment protocol. The specimens were sandblasted with 50 μm Al2O3 for 20 s; 2 bar pressure was maintained for air abrasion. Distribution of groups was as follow G1: Prepared enamel surface treatment of each tooth was according to the manufacturer’s instructions. G2: The prepared enamel surface of each tooth was subjected to Erbium,Chromium-Doped: Yttrium, Scandium, Gallium, and Garnet laser application. Light cured adhesive resin cement was applied to fitting surface of each ceramic specimen. To simulate thermal aging, the samples were subjected to 5000 thermal cycling in a thermocycler. By dividing the failure load (N) by the bonding area (mm2), debonding loads were calculated as shear stress (MPa). Numerical data were presented as mean and standard deviation values. They were explored for normality by checking the data distribution using Shapiro–Wilk test. Data showed parametric distribution and were analyzed using independent t-test. The significance level was set at p ≤ 0.05 within all tests. Statistical analysis was performed with R statistical analysis software version 4.1.2 for Windows. RESULTS: Group (II) (15.84 ± 3.09) had significantly higher mean value than group (I) (13.69 ± 2.36) (t = 2.15, p = 0.041). CONCLUSION: Within the limitation of this study, it was revealed that the laser surface treatment for tooth substrate plays a significant role in increasing the shear bond strength of laminate veneers.