This paper is a comprehensive assessment of the health and environmental impacts of gari factories on their host communities in Oyo State, Nigeria. Four health centers in the host communities of the gari factories under study were surveyed using structured questionnaires to gather data on the prevalent illnesses and perceptions of the local health personnel. The IITA Health Center serviced the IITA gari factory, Moniya served the Laniyonu gari factory, Agunrege catered to the Agunrege gari factory, and Aafin Health Center provided healthcare services to the Sakutu Sabo Oyo gari factory. The study revealed valuable insights into the demographic and socio-economic characteristics of the health personnel respondents at these health centers. Notably, these health personnel played a key role in understanding the health dynamics within their communities. The health personnel's responses highlighted the gari factories' impact on the health of their respective communities and the prevalent health issues. Malaria was common in all communities, while headaches, respiratory infections, and cough were reported in specific areas. Stagnant water and cassava peels were identified as sources of environmental concern. In addition to the health assessment, the study explored the social implications of gari processing in these communities. Residents' perceptions of the gari factories varied, with some communities appreciating their contributions to employment and environmental development while others raised concerns about environmental risks. The findings of this study indicate that Agunrege gari factory poses the highest health threats and environmental risk to its host community due to concerns related to smoke and air pollution. These insights can inform policies and interventions to mitigate the negative impact of gari processing on health and the environment in these communities.