As a counterpart to the commutative Galois theory of groups acting on rings one may consider Lie algebras acting on rings as Lie algebras of derivations. A peculiar situation where techniques from both areas meet and blend arises when studying derivations of graded rings and Clifford systems. Some results for strongly graded rings might benefit from a rephrasing in terms of Hopf algebra actions, the Hopf algebras being smash products of dual group algebras and enveloping algebras, but we did not go into these matters here for simplicity’s sake. In the first part of the paper we provide general results concerning R,derivations of a graded ring of type G, R = eJntC; R, (where e is the neutral clement of G) into weakly cancellative R-bimodules M which need not be graded. In case A4 is graded as a left R-module a useful criterion for an R,derivation D: R -+ M to be a graded (left) R,-morphism may be given. We then investigate when an R,.-derivation is a sum of such “graded” derivation, cg., we establish that for a finitely generated abelian group G, every R,-derivation of R into a weakly cancellative graded R-bimodule has a decomposition as a sum of graded R,-derivations. In the second section we prove a result relating the R,-derivations to some Galois cohomology group for G and as a consequcncc of this, it follows that for a strongly graded ring Hochschild cohomology (whenever defined) coincides with some Galois cohomology of the grading group. Along the way we provide an interesting extension of results about the Miyashita auto-morphisms of strongly graded rings. Our approach leads to some applications in the crossed product theory for Azumaya algebras or even central simple algebras, presenting a new point of view on crossed product structures which seems to deserve further development. In the light of these applications and also to the benefit of general applicability, the consideration of Clifford systems which are not graded rings is important. For example, every algebra generated by invertible elements may be viewed 485 0021-8693/86 $3.00