Gain Suppression Research Articles

Efficacy of Mycotoxin Binder on Broiler Performance, Organ Weight, Wishbone Weight, and Gut Length: A Meta-Analysis

Mycotoxin-contaminated feed is one of the main causes of contamination that may increase broiler mortality and impair their production. A total of 161 in vivo data acquired from 31 published articles were used as a database for determining the effectiveness of mycotoxin binders on performance and health of broiler. The Hedges’ d value was employed as a measure of effect size (ES) in the present meta-analysis. Increasing mycotoxin binder in feed enhanced body weight (ES=0.784; P<0.001), decreased feed conversion ratio (ES=-0.87; P<0.001), and decreased mortality (ES=-3.98; P<0.001). In terms of average daily gain and mortality suppression, the finisher phase demonstrated the greatest effectiveness of the binder usage compared to the starter and finisher phases. The effectiveness of binders in lowering the incidence of mycotoxin in feed was beneficial in reducing mortality and enhancing broiler performance. In addition, its application into feed may enhance the health condition of broilers by enhancing organ weights and gastrointestinal health.

Antidepressant-like and antistress effects of the ACTH(4–10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress

Current antidepressant therapy shows substantial limitations, and there is an urgent need for the development of new treatment strategies for depression. Stressful events and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis play an important role in the pathogenesis of depression. HPA axis activity is self-regulated by negative feedback at several levels including adrenocorticotropic hormone (ACTH)-mediated feedback. Here, we investigated whether noncorticotropic synthetic analogs of the ACTH(4–10) fragment, ACTH(4–7)-Pro-Gly-Pro (Semax) and Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10]ACTH(4–10)-NH2 (Melanotan II (MTII), a potent agonist of melanocortin receptors), have potential antidepressant activity in a chronic unpredictable stress (CUS) rat model of depression. Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII. Rats were monitored for BW and hedonic status, as measured in the sucrose preference test. We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF. In the forced swim test, no effects of the CUS procedure or peptides on the duration of rat immobility were detected. Our findings show that in the CUS paradigm, systemically administered ACTH(4–10) analogs Semax and MTII exert antidepressant-like effects on anhedonia and hippocampal BDNF levels, and attenuate markers of chronic stress load, at least in male rats. The results support the argument that ACTH(4–10) analogs and other noncorticotropic melanocortins may have promising therapeutic potential for the treatment and prevention of depression and other stress-related pathologies.

Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects.

Corticosteroids play a crucial role as anti-inflammatory and immunomodulatory agents in dermatology and other medical specialties; however, their therapeutic benefits are accompanied by significant risks, especially in older adults. This review examines the broad spectrum of adverse effects (AEs) associated with oral corticosteroid therapy and offers strategies to prevent, monitor, and manage these issues effectively in older adults. AEs associated with systemic corticosteroids include immune suppression, gastrointestinal problems, hyperglycemia, insulin resistance, weight gain, cardiovascular complications, ocular issues, osteoporosis, osteonecrosis, muscle weakness, collagen impairment, psychiatric symptoms, and adrenal suppression. To minimize these AEs, tailored dosing and duration, frequent monitoring, and additional preventative measures can be employed to optimize corticosteroid treatment. By customizing management plans to the specific needs and risk factors associated with each patient, clinicians can promote the safe and effective use of oral corticosteroids, ultimately improving outcomes and quality of life in patients with inflammatory dermatologic disorders.

The patterns of anti-compensatory saccades of the SHIMP paradigm can differentiate vestibular migraine from healthy individuals.

The aim of the present study was to characterize the HIMP and SHIMP test findings in individuals with vestibular migraine. The study comprised two groups- group I consisted of twenty five adults diagnosed with Vestibular migraine, and group II comprised twenty-five age matched healthy individuals. HIMP & SHIMP were administered using the ICS impulse system for both groups. Mann-Whitney U test revealed a significant difference (p< 0.05) in VOR gain and VOR suppression gain between the vestibular migraine and healthy individuals. All the subjects in the vestibular migraine group manifested either of the four patterns of anti-compensatory saccades (ACS): (a) bilaterally absent ACS, (b) bilaterally scattered ACS or (c) typical ACS on one side with scattered ACS on the other side (d) unilaterally absent ACS. On the other hand, all the healthy individuals exhibited the presence of an organised ACS bilaterally. VOR pathway is affected in individuals with vestibular migraine. Also, various patterns of ACS are more effective in identifying the subtle vestibular lesion in vestibular migraine. These patterns are useful in differentiating vestibular migraine from healthy individuals.

A simple sinusoidal curve‐based one‐dimensional periodic leaky‐wave antenna for high‐gain continuous beam scanning

AbstractA novel technique is presented based on a sinusoidal curve‐shaped one‐dimensional periodic leaky‐wave antenna to eliminate open stopband (OSB) and enhance gain. The radiating stub is inspired by a sinusoidal curve showing zero phase constant at a single broadside frequency (9 GHz) and ripple‐free attenuation constant. The technique is first used on a unit cell with half‐cycle sinusoidal‐curved radiating stub to achieve uniform gain and OSB suppression. Subsequently, to further improve the gain, a unit cell with a full‐cycle sinusoidal‐curved radiating stub with an offset introduced at the centerline is applied. Finally, the full‐cycle sinusoidal stub is modified by introducing a pair of inclined “branching” half‐cycle sinusoidal stubs at an angle θ° from the centerline to further enhance the gain. A 4.65 dB gain improvement is observed along with complete OSB elimination for the proposed design.

Generation of THz radiation through molecular modulation in hydrogen-filled hybrid anti-resonant fibers.

We study the generation of narrowband terahertz (THz) pulses by stimulated Raman scattering and molecular modulation in hydrogen-filled hybrid hollow-core fibers. Using a judicious combination of materials and transverse structures, this waveguide design enables simultaneous confinement of optical and THz signals with reasonably low attenuation, as well as high nonlinear overlap. The THz pulses are then generated as the second Stokes band of a ns-long near-infrared pump pulse, aided by Raman coherence waves excited in the gaseous core by the beat-note created by the pump and its first Stokes band. Optimization of the fiber characteristics facilitates phase matching between the corresponding transitions and coherence waves while avoiding coherent gain suppression, resulting in potential optical-to-THz conversion efficiencies up to 60%, as confirmed by rigorous numerical modelling under ideal zero-loss conditions. When the current optical material constraints are considered, however, the attainable efficiencies relax to 0.2%, a still competitive value compared to other systems. The approach is in principle power and energy scalable, as well as tunable in the 1-10 THz range without any spectral gaps, thereby opening new pathways to the development of fiber-based THz sources complementary to other mature technologies such as quantum cascade lasers.

Suppressive Effects of Neuromedin U Receptor 2-Selective Peptide Agonists on Appetite and Prolactin Secretion in Mice.

Neuromedin U receptor 2 (NMUR2), which is expressed in the central nervous system (CNS) including the hypothalamus, has been noted as a therapeutic target against obesity. We previously reported that intranasal administration of CPN-219, a NMUR2-selective hexapeptide agonist, suppresses body weight gain in mice; however, there is no detailed information regarding its CNS effects. Recently, in addition to appetite suppression, stress responses and regulation of prolactin (PRL) secretion have also attracted attention. NMUR2 expressed in the hypothalamic tuberoinfundibular dopaminergic neurons has emerged as an alternative target for treating hyperprolactinemia. Here, CPN-219 decreased food intake up to 24 h after administration at a dose of 200 nmol, resulting in body weight gain suppression, although grooming and anxiety-like behaviors were transiently induced. Interestingly, the restraint stress-induced increase in plasma PRL levels was significantly suppressed at a lower dose of 20 nmol, indicating the potential for drug development as an anti-PRL agent of NMUR2-selective agonists.

A Sigle-Layer Dual-Band Shared-Aperture Antenna With High Gain and Sidelobe Suppression Based on High-Order Mode for Vehicular Communications

A Sigle-Layer Dual-Band Shared-Aperture Antenna With High Gain and Sidelobe Suppression Based on High-Order Mode for Vehicular Communications

An Integrated Microwave and Millimeter-Wave Circularly Polarized Antenna with ISM Band Gain Suppression Performance

An Integrated Microwave and Millimeter-Wave Circularly Polarized Antenna with ISM Band Gain Suppression Performance

Psychedelics and critical theory

AbstractIn the monograph Philosophy and Psychedelics: Frameworks for Exceptional Experience, Hauskeller raises the important subject of individualization and alienation in psychedelic psychotherapy. Under the prevailing conditions of neoliberalism, Hauskeller contends that psychedelic-assisted psychotherapy appropriates Indigenous knowledges in an oppressive fashion, may be instrumentalised to the ends of productivity gain and symptom suppression, and may be utilised to mask societal systems of alienation. Whilst offering a valuable socio-political critique of psychedelics' clinical uptake, we suggest that Hauskeller's view does not adequately acknowledge the ways in which psychedelics offer a challenge to the Western reductive bio-medical understanding of healing and wellbeing. It is contended herein that Indigenous knowledges, in alliance with a range of emerging sciences, offer both an engagement with ethnomedicines in a less harmfully appropriative fashion, and a renewed understanding of the means by which psychedelics achieve therapeutic change. With this understanding, what becomes apparent are the potential ways in which psychedelic medical usage may produce positive feedback upon the oppressive systems in which we are embedded. That is, transpersonal experience through encounters with the ineffable may offer a revisioning of Western psychology and cognitive science. Indeed, if psychedelics are approached with an understanding of the actual means by which they produce therapeutic outcomes—changing mental representations of the self, or self-insight derived through non-ordinary states of consciousness—then psychedelic psychotherapy offers a reimagining of psychiatric nosology, challenging conventional understandings of both pathology and wellbeing through an overturning of specified and discrete deficit models of psychopathology. This may provide both a critique of the prevailing categories used to describe madness and an expansion of our understanding of the mind-body relation, as well as an increased recognition of positive psychology grounded in cross-cultural contemplative traditions. This provides an implicit challenge to the pharmaceutical industrial-complex and its profit motives; and the corresponding neoliberalist, globalising tendencies which Hauskeller seeks to address.

Intelligent Hierarchical Network Slicing Based on Dynamic Multi-Connectivity in Cell-Free Distributed Massive MIMO Systems

In order to provide customized services for the future sixth-generation (6 G) mass business, we propose a two-timescale intelligent radio access network (RAN) slicing scheme under the architecture of cell-free distributed massive multiple-input multiple-output (MIMO) systems. Cell-free distributed massive MIMO systems have powerful macro diversity gain and multi-user interference suppression capabilities to improve the performance of different slices, and are more flexible in terms of service types based on network slicing. In the proposed scheme, we utilize the long-term and short-term trends of network to achieve adaptive resource allocation at different timescales, so as to utilize resources more effectively and meet performance requirements in parallel. Moreover, multi-connectivity is utilized to improve link reliability and further improve system performance, and user clustering reduces the impact of pilot contamination on system performance. In order to implement the RAN control strategy effectively, an efficient two-level deep reinforcement learning framework is proposed and the multi-agent reinforcement learning algorithm is used to realize efficient network resource interaction in multi-device scenarios. Simulation results further verify the effectiveness of the proposed intelligent RAN slicing scheme.

Effect of rotational Raman response on ultra-flat supercontinuum generation in gas-filled hollow-core photonic crystal fibers.

We experimentally and numerically investigate flat supercontinuum generation in gas-filled anti-resonant guiding hollow-core photonic crystal fiber. By comparing results obtained with either argon or nitrogen we determine the role of the rotational Raman response in the supercontinuum formation. When using argon, a supercontinuum extending from 350 nm to 2 µm is generated through modulational instability. Although argon and nitrogen exhibit similar Kerr nonlinearity and dispersion, we find that the energy density of the continuum in the normal dispersion region is significantly lower when using nitrogen. Using numerical simulations, we find that due to the closely spaced rotational lines in nitrogen, gain suppression in the fundamental mode causes part of the pump pulse to be coupled into higher-order modes which reduces the energy transfer to wavelengths shorter than the pump.

An Adaptive Infrared Small-Target-Detection Fusion Algorithm Based on Multiscale Local Gradient Contrast for Remote Sensing.

Space vehicles such as missiles and aircraft have relatively long tracking distances. Infrared (IR) detectors are used for small target detection. The target presents point target characteristics, which lack contour, shape, and texture information. The high-brightness cloud edge and high noise have an impact on the detection of small targets because of the complex background of the sky and ground environment. Traditional template-based filtering and local contrast-based methods do not distinguish between different complex background environments, and their strategy is to unify small-target template detection or to use absolute contrast differences; so, it is easy to have a high false alarm rate. It is necessary to study the detection and tracking methods in complex backgrounds and low signal-to-clutter ratios (SCRs). We use the complexity difference as a prior condition for detection in the background of thick clouds and ground highlight buildings. Then, we use the spatial domain filtering and improved local contrast joint algorithm to obtain a significant area. We also provide a new definition of gradient uniformity through the improvement of the local gradient method, which could further enhance the target contrast. It is important to distinguish between small targets, highlighted background edges, and noise. Furthermore, the method can be used for parallel computing. Compared with the traditional space filtering algorithm or local contrast algorithm, the flexible fusion strategy can achieve the rapid detection of small targets with a higher signal-to-clutter ratio gain (SCRG) and background suppression factor (BSF).

Circularly Polarized High-Gain Fabry-Perot Cavity Antenna with High Sidelobe Suppression

The proposed design approach improves the circularly polarized Fabry-Perot cavity antenna (CP-FPCA) by increasing gain and sidelobe suppression (SLS) while reducing the axial ratio (AR) and cross-polarization levels. Conventional CP-FPC antennas have a high AR due to the lack of independent control over circular polarization conditions. The solution proposes a double-layered circularly polarized partially reflecting surface (CP-PRS) that independently controls the circular polarization conditions at the design frequency f0 (10 GHz) for equal magnitudes and at a ±90° phase difference between orthogonal components of the transmitted waves. The PRS and artificial magnetic conductor (AMC) unit cells are employed to satisfy Trentini’s beamforming condition, leading to increased gain and SLS and lowered AR and cross-polarization levels. Consequently, the proposed CP-FPCA provides a 15.4 dBi high gain with 25.3% aperture efficiency and more than 23.5 dB high SLS in each plane. Moreover, it achieves an AR lowered by 0.12 dB and a cross-polarization level below −42 dB. A strong correlation between the simulations and experiments proves the practicality of our proposal.

Analysis of the performance of low gain avalanche diodes for future particle detectors

Low-Gain Avalanche Diodes (LGAD) are the sensor of choice for the timing detectors of the ATLAS and CMS experiments at the High Luminosity Large Hadron Collider (HL-LHC). This paper presents the results of static and dynamic performance evaluations of LGADs manufactured by Hamamatsu Photonics K.K. (HPK) and Brookhaven National Laboratory (BNL). Timing performance was measured using β-scopes after a static characterization of the device (current-voltage and capacitance-voltage curves) and a time resolution better than 35 ps was extracted under high operational bias voltage before irradiation. This value is considered within the nominal requirements of the ATLAS project for un-irradiated sensors. Transient Current Technique (TCT) was used to observe and analyze a gain suppression mechanism, i.e. a decrease in gain correlated with increased laser intensities. TCAD simulations were carried out to interpret the gain suppression of the BNL sensors under different conditions of bias voltage and laser intensity. A good correspondence between experimental observations and TCAD simulations was found.

Millimeter-Wave Filtering Metasurface Antenna Array With Printed RGW Technology

A millimeter-wave (MMW) printed ridge gap waveguide (PRGW) fed filtering metasurface antenna (MSA) array is presented for 5G applications. The MSA element consists of a parasitic loop and a stacked patch. The elaborately designed parasitic loop around MSA not only provides satisfactory lower stopband performance but also brings an in-band resonance. Meanwhile, another upper edge radiation null is generated by introducing two square-ring slots on the MSA, improving the suppression level. Therefore, with no extra filtering circuits, desirable filtering characteristics are achieved. A 1×4 filtering MSA array is fabricated and tested to demonstrate the concept. Based on measurement results, the array prototype exhibits an overall bandwidth of 27.2% within |S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> |<-10 dB. Besides, the average tested gain of about 11.1 dBi is realized, and the gain suppression outside the passband exceeds 27 dB on both sides.

Proportional Counter array (PCa) — a new concept and its realization

In this study, we introduce a new structure of micro-pattern gaseous detector, named proportional counter array (PCa). The standard Printed Circuit Board (PCB) process, which is cost-effective and easy to scale up, is used to manufacture the PCa prototypes. Both simulation and experimental studies were performed to characterise the prototypes, which demonstrated promising performance in terms of gas gain, rate capability, and ion backflow suppression. The prospects of the PCa technology are also discussed.

New insight into gain suppression and single event Burnout effects in LGAD

Low Gain Avalanche Detectors (LGADs) will be employed in the CMS MTD and ATLAS HGTD upgrades to mitigate the high levels of pile-up events expected in the High Luminosity phase of the LHC. Over the last several years, much attention has been focused on designing radiation-tolerant gain implants to ensure that these sensors survive the expected fluence (>1015 neq/cm2). This work reports several effects observed during our previous studies on two relevant phenomena Single Event Burnout (SEB) and carrier density-induced Gain Suppression (GS). Influence of irradiation level, pad configuration and gain layer depth on SEB are discussed. In this paper, we also extend GS study with a new insight into the spatio-temporal dynamics of charge transport in LGAD, probed with a focused ion beam.

Test-Retest Reliability, Effects of Age and Comparison of Horizontal 2 Semicircular Canals Gain Values between Head Impulse and Suppression Head Impulse Paradigms.

This study investigates the test-retest reliability, aging effects, and differences in horizontal semicircular canals gain values between the head impulse paradigm and suppression head impulse paradigm. Sixty healthy adult subjects aged 22-76-year-old (mean ± standard deviation=47.27 ± 18.29) participated in the head impulse paradigm and suppression head impulse paradigm using the video head impulse test. The Head impulse paradigm was used to assess all 6 semicircular canals, while suppression head impulse paradigm measured only the horizontal canals. Twenty subjects aged 22-40-year-old (25.25 ± 4.9) underwent a second session for the test-retest reliability. There were good test-retest reliability for both measures (right horizontal head impulse paradigm, intraclass correlation coefficient=0.80; left horizontal head impulse paradigm, intraclass correlation coefficient=0.77; right anterior head impulse paradigm, intraclass correlation coefficient=0.86; left anterior head impulse paradigm, intraclass correlation coefficient=0.78; right posterior head impulse paradigm, intraclass correlation coefficient=0.78; left posterior head impulse paradigm, intraclass correlation coefficient=0.75; right horizontal suppression head impulse paradigm, intraclass correlation coefficient=0.76; left horizontal suppression head impulse paradigm, intraclass correlation coefficient=0.79). The test-retest reliability for suppression head impulse paradigmanti-compensatory saccade latency and amplitude were moderate (right latency, intraclass correlation coefficient=0.61; left latency, intraclass correlation coefficient=0.69; right amplitude, intraclass correlation coefficient=0.69; left amplitude, intraclass correlation coefficient=0.58). There were no significant effects of age on head impulse paradigm and suppression head impulse paradigm vestibulo-ocular reflex gain values and suppression head impulse paradigmsaccade latency. However, the saccade amplitude became smaller with increasing age, P < .001. The horizontal suppression head impulse paradigm vestibuloocular reflex gain values were significantly lower than the head impulse paradigm for both sides (right, P = .004; left, P = .004). There was good test-retest reliability for both measures, and the gain values stabilized with age. However, suppression head impulse paradigm anti-compensatory saccade latency and amplitude had lower test-retest reliability than the gain. The suppression head impulse paradigm vestibulo-ocular reflex gain was lower than the head impulse paradigm and its anti-compensatory saccade amplitude reduced with increasing age.

Infrared Small Target Detection Based on Local Contrast-Weighted Multidirectional Derivative

Realizing robust infrared small target detection in complex backgrounds is of great essence for infrared search and tracking (IRST) applications. However, the high-intensity structures in background regions, such as the sharp edges, make it a challenging task, especially when the target is with low signal-to-clutter ratio (SCR). To address this issue, we propose an infrared small target detection method using local contrast-weighted multidirectional derivative (LCWMD). It is a robust detector that comprehensively considers the target property, background information, and the relation between them. First, we take into account the approximate isotropy of the infrared small target and present a new multidirectional derivative with penalty factors based on the Facet model to develop the target salience in the local region. Second, a dual local contrast fusion model with the tri-layer design is introduced to amplify the difference between the target and the background, so as to further suppress the high-intensity structural clutters. Finally, the LCWMD map is obtained by weighting the above two filtered maps, after which an adaptive segmentation operation is applied to accomplish the target detection. The results of comparative experiments implemented on real infrared images demonstrate that our method outperforms other state-of-the-art detectors by several times in terms of signal-to-clutter ratio gain (SCRG) and background suppression factor (BSF).