Future Concepts Research Articles

Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future

Proteomics accelerates diagnosis and research of muscular diseases by enabling the robust analysis of proteins relevant for the manifestation of neuromuscular diseases in the following aspects: (i) evaluation of the effect of genetic variants on the corresponding protein, (ii) prediction of the underlying genetic defect based on the proteomic signature of muscle biopsies, (iii) analysis of pathophysiologies underlying different entities of muscular diseases, key for the definition of new intervention concepts, and (iv) patient stratification according to biochemical fingerprints as well as (v) monitoring the success of therapeutic interventions. This review presents—also through exemplary case studies—the various advantages of mass proteomics in the investigation of genetic muscle diseases, discusses technical limitations, and provides an outlook on possible future application concepts. Hence, proteomics is an excellent large-scale analytical tool for the diagnostic workup of (hereditary) muscle diseases and warrants systematic profiling of underlying pathophysiological processes. The steady development may allow to overcome existing limitations including a quenched dynamic range and quantification of different protein isoforms. Future directions may include targeted proteomics in diagnostic settings using not only muscle biopsies but also liquid biopsies to address the need for minimally invasive procedures.

Designing a psycho-pedagogical space with considerations of spatial requirements, such as lighting and its sensory aspect for autistic children

The sensory particularities of children with autism make their vision of the world different from that of non-autistic people. The architectural environment affects the well-being of autistic children in a direct way. Through this research, we intend to give suggestions and spatial design considerations of a psycho-pedagogical setting to guarantee that autistic children receive the best education possible. This objective is achieved by making sure that the autistic child is comfortable and well-cared in a psycho-pedagogical environment, as well as by assuring his effectiveness and integration into his surroundings. It is crucial to have enough architectural space and a suitable architectural setting in order to foster the child's difficult relationship with his environment, enhance spatial skills, and promote sensory well-being through light. This research based on qualitative approach highlights architectural solutions and recommendations implemented in future conception to offer a design adapted to autistic children. It also describes the conditions and guidelines that ensure an autistic youngster receives the surroundings he needs to be healthy.

Social interaction of people living with dementia in residential long-term care: an ecological momentary assessment study

Abstract Background The importance of social health is increasingly recognized in dementia research. For most people living with dementia, their social environment changes as the disease progresses, especially when they move into a long-term care facility. However, maintaining social interactions in the new living environment contributes significantly to health and quality of life. Staff and other residents are the most readily available interaction partners to provide this. The aim of this study is to investigate the frequency, contexts, partners and influencing factors (personal and contextual) of social interactions of people living with dementia in residential long-term care. Methods Participants were observed for two days in 20-min slots (from 7 am to 7 pm) in 12 long-term care facilities in Germany. The Maastricht Electronic Daily Live Observation Tool (MEDLO-tool) was used for ecological momentary assessment. Age, gender, functional status, cognitive status and length of stay at the facility were recorded. Generalized linear mixed-effect models were used for the data analysis. Results In all, 106 people living with dementia (average age: 85.16 ± 7.42 years, 82.9% female) were observed at 6134 time points. No social interaction take place in 71.9% of the observations. The place where the participants spend their time influences the occurrence of social interaction (p < 0.001), with a significantly higher probability of social interaction in communal spaces. Most frequently, interaction takes place with staff (43.4%), closely followed by other residents (40.9%), with the context (location, p < 0.001; time of day, p < 0.001) and functional status (care level, p < 0.001) influencing which of the two groups people living with dementia interact with. Conclusion A better understanding of the context of social interactions and its influencing factors provide a basis for more targeted interventions. As the increasing staff shortage will further limit the opportunities for social interaction with staff, future concepts should focus on other residents. Meaningful activities that enable people living with dementia to co-operate and share responsibility can provide a stimulating framework for this. In addition, social assistance robots and the application of peer-mentoring/leading represent promising approaches for creating a socially interactive environment.

Carbon-capture potential of industrial by-products for post-carbon society

To contribute to the realization of carbon neutrality by 2050, the authors have focused on the fact that some of the by-products of social activities have the ability to fix carbon dioxide, and have envisioned the creation of a carbon-capture urban environment using these materials. Also, the authors have emphasized carbon capture capabilities of industrial waste disposal facilities named as “Disposal Facility CCS”, since these are where substances containing large amounts of free calcium accumulate. As described herein, the authors have emphasized several kinds of by-product as carbon capture materials, and propose datasets of these carbon capture capabilities by measurement using constant flow aeration type CO2 fixation testing, which we developed. Furthermore, using these datasets, the authors estimate the potential carbon capture capability of a specific industrial waste disposal facility as an example of “Disposal Facility CCS”, and demonstrate its relative effectiveness compared to that of forests. Furthermore, the authors estimate the carbon capture potentials of industrial by-products generated in Japan as some examples. Consequently, this study proposed carbon capture future society concept using CO2 fixation materials on the basis of the estimation results conducted in this study.

‘We/One devastate(s) the world’: Of Deserts, Chaos & Khōra

If the word ‘devastated’ feels most appropriate when thinking of the passing of a beloved one, it also undergirds, through the waste of its desert, two essential notions of Western philosophy and literature: chaos and khōra. Looking at our world twenty years after Derrida’s passing, and at how for more than five decades he thought and wrote on the notion of world, this essay examines the radicality of Derrida’s deconstruction for our past and future conceptions of a world, of ourselves, and of each and any threshold between these terms.

Clinical Dilemma Of Bilateral Hematosalpinx In Ectopic Pregnancy: Case Report

Background: Blastocyst implantation outside the uterine cavity leads to ectopic pregnancy. About 96% of ectopic pregnancies occur in the fallopian tubes, where it most frequently occurs; the fimbrial end accounts for 11% of all ectopic pregnancies. There was an uncommon type of ectopic pregnancy called bilateral tubal ectopic pregnancy. Bilateral tubal ectopic pregnancy is estimated to affect 1 out of 725 - 1580 ectopic pregnancies or 1 out of 200,000 live births. However, the villi quickly penetrate the endosalpinx once the implantation of the ectopic pregnancy has occurred before reaching the tubal wall and peritoneum. Vascular growth and a peritubal hematoma or hematosalpinx, which frequently involves the contralateral tubal section, are also present with this penetration. The purpose of this article is to report on the dilemmas that often occur in the case of bilateral hematosalpinx in ectopic pregnancy. Case Description: In this report, we discuss a 33-year-old woman with a positive pregnancy test and transvaginal ultrasound result that was suggestive of ectopic pregnancy in a stable hemodynamic state. The patient underwent an exploratory laparotomy, which showed bilateral hematosalpinx with right ectopic pregnancy with damaged fimbria. The left fallopian tube had a blue-purple bulge that suggested hematosalpinx secondary to ectopic pregnancy rather than bilateral ectopic pregnancy condition. The decision for definitive management was made, right salpingectomy puncture and drainage of the hematosalpinx were performed without complication. The final diagnosis was confirmed on pathology examination that showing chorionic villi within the right damaged fimbria, focal decidua, a few trophoblast-like cells that indicated ectopic pregnancy in the left tubal cavity. Conclusion: This approach encourages both shared decision-making and preparedness, both of which are required to provide patient-centered and comprehensive caremanagement such as bilateral hematosalpinx in ectopic pregnancy case, that must always be individualized, and patient's desire for future conception must be taken into account.

Margaret Mead: un percorso antropologico contemporaneo

This article deals with some lesser-known key points of Margaret Mead's unconventional pathways of life and work. She raised many transcultural issues regarding female and male sexes that are still relevant and continue to animate current academic and politicaldebates. Mead’s numerous ethnographic research projects were developed mainly in field studies in Oceania – Samoa, Papua New Guinea, Bali – between the 1920s and the 1950s. These studies were revisited until the 1970s, within the framework of the Nature/Culture entanglement, distinctive of the Culture and Personality School Mead belonged to. This article interfaces Mead’s early major works with biographical and autobiographical writings, providing an analysis of Mead’s transcultural cross-examination of differentforms of family and social relations, whose results show how the so-called «sexual models» are cultural constructions and not natural matters, as usually claimed in western societies. The deconstruction of the «naturalness» of sexual models was a starting point for the elaboration of the future concept of «gender», discussed in early and current Women Studies, Gender Studies and Feminist Anthropology. Mead sustained the possibility of changing the sex-based social roles and it raised conservative hostilities, but also a progressive consensus. Both in her scientific production and in her bisexually oriented life experience, as expressed in many letters she sent to her lover and professor Ruth Benedict, Mead’s aims were to disseminate new knowledge on human complexity. Mead wanted to make this knowledge understandable to everyone in order to eradicate stereotyped visions and attitudes, including the sexual binary barriers that in her view precluded a free development of individual potential.

The Role of Artificial Intelligence in Scientific Writing

Artificial intelligence (AI) has evolved rapidly in the last century. Once a futuristic concept with negative connotations, AI has now begun to permeate various fields, reaching academic and scientific writing. In scientific writing, AI applications promise to significantly improve writing accuracy, provide quality control, and thereby enhance manuscript evaluation, among other possible contributions. It is generally agreed that AI and machine learning tools may become writing assistants if involved in writing tasks. Keywords: Artificial Intelligence, Scientific Writing

Formiranje novih pravaca historiografije: Aktuelna konceptualizacija modernosti

The article deals with the modern problems of archival science, historiography, source studies in the post-Soviet space of science of the Russian Federation, summarizes the results of the science of the past century, determines the prospects of future relevant concept ology of modernity. The author examines the state of archival affairs in the Republic of Kalmykia on the problems of regional history, shows the main characteristics of modern historical science in the region, legitimate interests in the development of archeography. For the first time in the history of the state, a systemic failure of archival science as a form of manifestation of record keeping, the need to rebuild the archival system is shown, the urgency of the problem of the unified state archival fund (EGAF) is indicated: its formation, formation, preservation, responsibility for its preservation. One of the features of archival funds is their classification, the modern correct structure of preservation and their origin allows us to determine the place and their role in the history of the archival service, to show their genres and fields of knowledge. The author emphasizes the importance and world practice of modern archival science in the field of cognitive space, opens up the possibility of analyzing new facts in the history of Russian statehood, concluding that the actualization translation concluding that the actualization of modern conceptology makes it possible to form new directions in the science of historical knowledge of the past. With the historical development, the problems of knowledge aimed at its humanization are increasingly being considered.

Konservative Transkulturalität oder Paradoxien der Moderne?

Abstract The genre of the novel of the future is usually reduced to a few canonised texts in diachronic longitudinal sections. This article, instead, attempts to explore the synchronic dynamics of the genre in the interwar period using the example of the future novels by the Austrian author Walther Eidlitz, who, after his expressionist beginnings, wrote religious-mythical texts in which a counterweight is sought against the irregularly differentiating modernity. On the eve of the Third Reich, the novels Zodiak (1930) and Das Licht der Welt (1932) outline a tableau of possibilities in which the ambivalences of modernity are named and productively integrated into a future concept of leadership based on the protagonist's search for identity, a Greek-Turkish migrant, and his negotiation processes between religion and technology as well as archaic and modern living environments.1

Seismic Wave Detectability on Venus Using Ground Deformation Sensors, Infrasound Sensors on Balloons and Airglow Imagers

AbstractThe relatively unconstrained internal structure of Venus is a missing piece in our understanding of the formation and evolution of the Solar System. Detection of seismic waves generated by venusquakes is crucial to determine the seismic structure of Venus' interior, as recently shown by the new seismic and geodetic constraints on Mars' interior obtained by the InSight mission. In the next decade multiple missions will fly to Venus to explore its tectonic and volcanic activity, but they will not be able to conclusively detect seismic waves, despite their potential to detect fault movements. Looking toward the next fleet of Venus missions after the ones already decided, various concepts to measure seismic waves have been proposed. These detection methods include typical geophysical ground sensors already deployed on Earth, the Moon, and Mars; pressure sensors on balloons; and imagers of high altitude emissions (airglow) on orbiters. The latter two methods target the detection of the infrasound signals generated by seismic waves and amplified during their upward propagation. Here, we provide a first comparison between the detection capabilities of these different measurement techniques and recent estimates of Venus' seismic activity. In addition, we discuss the performance requirements and measurement durations required to detect seismic waves with the various detection methods. Our study clearly presents the advantages and limitations of the different seismic wave detection techniques and can be used to drive the design of future mission concepts aiming to study the seismicity of Venus.

Growing Semiconductor Industry in India

This paper delves into the growing semiconductor industry in India, and its importance in every aspect of present and future high data processing speed. Semiconductors are crucial electronic components for quantum computing, artificial intelligence (AI), medical devices, aerospace and defence systems, etc. Thus, the use of semiconductors for these most important and future ease concepts, this paper is an understanding approach to the growing importance of semiconductors in India

Paving the Way for Sustainable UAVs Using Distributed Propulsion and Solar-Powered Systems

Hybrid systems offer optimal solutions for unmanned aerial platforms, showcasing their technological development in parallel and series configurations and providing alternatives for future aircraft concepts. However, the limited energetic benefit of these configurations is primarily due to their weight, constituting one of the main constraints. Solar PV technology can provide an interesting enhancement to the autonomy of these systems. However, to create efficient propulsion architectures tailored for specific missions, a flexible framework is required. This work presents a methodology to assess hybrid solar-powered UAVs in distributed propulsion configurations through a two-level modeling scheme. The first stage consists of determining operational and design constraints through parametric models that estimate the baseline energetic requirements of flight. The second phase executes a nonlinear optimization algorithm tuned to find optimal propulsion configurations in terms of the degree of hybridization, number of propellers, different wing loadings, and the setup of electric distributed propulsion (eDP) considering fuel consumption as a key metric. The results of the study indicate that solar-hybrid configurations can theoretically achieve fuel savings of up to 80% compared to conventional configurations. This leads to a significant reduction in emissions during long-endurance flights where current battery technology is not yet capable of providing sustained flight.

Inflammation of the temporalis muscle and adjacent nerve tissue in giant cell arteritis: expanding the spectrum of inflammatory lesions.

To investigate the histopathological features of the temporalis muscle (TM) and adjacent nerve tissue in active cranial giant cell arteritis (C-GCA). Temporal artery biopsy (TAB) specimens containing fragments of the TM from patients with active C-GCA fulfilling the 2022 ACR/EULAR classification criteria (n = 11) were assessed by conventional histology and immunohistochemistry in comparison with non-GCA controls (n = 3). Clinical, laboratory and imaging features based on patient charts at time of biopsy were retrospectively recorded. The majority of the studied TAB specimens showed inflammation of the TM (10/11) and adjacent nerve fascicles (7/11) that was characterized by prominent endomysial lymphomonocytic infiltrates, whereas controls showed no inflammatory lesions and no disruption of the local architecture. Association of active C-GCA with sarcolemmal MHC class I (8/8) and MHC class II (6/11) upregulation suggests primary inflammation of the TM in a subset of patients. αB-Crystallin positivity (10/11) highlights areas of pre-necrotic myofibres within the TM. The presence of endomysial fibrosis, signs of atrophy and variations of muscle fibre size suggest a rather longstanding and potentially subclinical process of myoinflammation. Our results expand the spectrum of inflammatory lesions known to be associated with active C-GCA. Specifically, inflammatory infiltration of the TM and adjacent nerve structures could contribute to localized symptoms of the temporomandibular region and may be included in future concepts of pathophysiology.

Comparison of non-premixed and premixed flamelets for ultra WET aero engine combustion conditions

The Water-Enhanced Turbofan (WET) is a future concept for aero engine applications being developed by MTU Aero Engines AG. Steam is injected into the combustion chamber to reduce temperature peaks and emission of pollutants. Depending on the steam content, the combustion process is modified. To analyze the effect of steam on the reaction kinetics and the temperature, detailed chemistry has to be employed. By comparing laminar flame speed and mole fraction distribution across the flame front, an appropriate chemical mechanism for the considered operating conditions including high steam loads was selected. Tabulated chemistry based on flamelets was employed, which enables the use of complex mechanisms in CFD analysis at reasonable computational costs. A comparison of premixed freely propagating flames and non-premixed counterflow diffusion flames to represent the manifolds was investigated. Various definitions of the progress variable are studied for ultra WET combustion considered under aero engine conditions. The manifolds from both model flames are compared from dry to ultra WET conditions with kerosene in an adapted Sandia Flame D large eddy simulation. While the premixed flamelets are generated efficiently, the results obtained with non-premixed flamelets are more reliable for the range of operating conditions investigated.

Neural networks utilization in the video game industry

The scope of the video game industry and the use of neural networks in it have been studied. The impact of this technology on the computer games development process has been analyzed, the efficiency of its application in this area noted. The generalized scheme of video games development with identification of the stages most favorable for neural networks application has been considered. The possibilities of artificial intelligence in the video game characters’ visual image development, starting from the idea stage, touching the concept creation and ending with the realization stage, have been studied. The possibility of optimizing this process by implementing neural network technology has been shown. The neural networks application in the processes of writing game scripts and implementing dialog voicing in a game has been analyzed. The difference between the variability of plots and conversations of game characters created with the use of artificial intelligence model has been shown. The future concept of using neural networks as a digital twin of a video game developer has been considered. Estimates of the video game industry development through the generative artificial intelligence implementation have been formulated. As the study result, the positive influence of neural networks application on the computer games development up to the possible full automation of the industry under consideration due to the active use of this technology in the near future has been proved.

EVOLUTION AND IMPACT OF ARTIFICIAL INTELLIGENCE IN CHATBOTS

Artificial Intelligence (AI) is reshaping the world and technology, no longer a futuristic concept but a present reality in our daily lives. Businesses are rapidly adopting AI to automate processes, leading to the creation of intelligent agents known as chatbots. These chatbots have revolutionized business communication and significantly enhanced customer satisfaction. This paper explores the history and development platforms of chatbots, examining their integration into daily life despite often undefined purposes. Chatbots use pattern recognition to generate responses, raising questions about moral issues, security, and legitimacy due to their growing popularity. A key focus is on ChatKanoon, a multilingual AI chatbot designed for the Indian legal system. This study analyzes its impact on the Indian legal framework and its potential to revolutionize legal aid in India and other developing countries. Additionally, the research paper covers the basic features, connectivity, services offered, accuracy, and technology providers of chatbots and virtual assistants implemented by Indian banks.

Research on Urban Renewal Design in the Context of the Future Community Concept

As urbanization accelerates, traditional cities face numerous challenges such as aging infrastructure, limited community functions, and inadequate environmental sustainability. The concept of the "future community," as an innovative approach to urban development, emphasizes the application of smart technologies, enhanced community participation, eco-friendly designs, and diversified economic growth, providing a new direction for urban renewal. This study aims to explore the application of the future community concept in urban renewal design through a combination of literature review, case studies, and data analysis, systematically analyzing the core characteristics of future communities and their impact on urban renewal. The research selects typical urban renewal cases from both domestic and international contexts, constructs a relationship model between future communities and urban renewal, and proposes a series of design strategies such as participatory design, smart technology integration, sustainable green design, and mixed-use development. Comparative analysis reveals that the future community concept significantly improves social inclusiveness, technological application levels, and environmental sustainability, while also boosting economic vitality. The use of data tables further validates the effectiveness of these design strategies, providing empirical support for urban planning and design. The study concludes that while the future community concept offers important guidance for urban renewal, challenges such as technological, financial, and policy issues must still be overcome during implementation. Finally, the paper offers relevant policy recommendations and future research directions to provide theoretical and practical references for building more livable, intelligent, and sustainable urban communities.

The weather today rocks or sucks for my tree: exploring the understanding of climate impacts on forests at high school level through tweets

Abstract. With the progression of global warming, impacts on the human sphere will undoubtedly increase. One prominent example at mid-latitudes is the stress on forests caused by climate change, which the BayTreeNet project (https://baytreenet.de/, last access: 30 July 2024) addresses from an interdisciplinary viewpoint. Scientists from physical climatology, dendroecology, and educational research collaborate to examine how long-term changes in weather patterns affect the state of trees, and how the atmosphere–tree relation can be used to the advantage of improving the communication of climate change effects to, in particular, high school students. This article presents a 1-week case study for the summer of 2021, when a distinct variability in weather patterns induced significant tree responses. The students of seven selected partner schools commented on the measured tree and weather data, which were available in real time, in the form of tweets and in conjunction with their educational geography program. The analyses of the tweets reveal that the students succeed in verbalizing the measured weather and, furthermore, manage to draw links between the stem diameter changes in trees and the weather variability. Problems arise with the use of less perceivable variables like the sap flow in the trees; also, the student posts exhibit shortcomings in establishing causal connections. Hence, the case study points to a discrepancy between describing basic environmental information and appreciating or understanding the underlying mechanistic links. This point will serve to refine future classroom concepts and, moreover, to enhance the communication of climate change effects on forests to the general public.

Research on Aircraft Engines and Advanced Power in Land, Sea and Air

This paper provides a comprehensive overview of advanced propulsion technologies in military applications across land, sea, and air domains. It examines the theoretical foundations of propulsion systems, tracing the evolution of aircraft engines from early piston designs to modern jet propulsion. The study explores current state-of-the-art technologies, including advanced turbofan engines, hybrid electric systems, and nuclear propulsion for naval vessels. Special attention is given to emerging fields such as unmanned aerial vehicle propulsion, hypersonic technologies, and stealth engine designs. The research also delves into futuristic concepts like magnetohydrodynamic propulsion and pulse detonation engines. Throughout the analysis, common themes of improved efficiency, enhanced power-to-weight ratios, and increased operational capabilities are highlighted. This paper aims to provide a holistic view of the current landscape and future trajectory of military propulsion technologies, underlining their critical role in shaping modern warfare capabilities.