Aneutronic fusion using commonly available fuel such as hydrogen and boron 11 (11B) is one of the most attractive potential energy sources. On the other hand, it requires 30 times higher temperature than deuterium–tritium fusion in a thermonuclear fusion reactor condition. Development of techniques to realize its potential for the experimental capability to produce proton-boron 11 (p-11B) fusion in the magnetically confined fusion device using neutral beam injection is desired. Here we report clear experimental exploration and measurements of p-11B fusion reactions supported by intense hydrogen beams and impurity powder dropper installed in the magnetic confinement plasma Large Helical Device. We measured a significant amount of fusion alpha particle emission using a custom designed alpha particle detector based on a passivated implanted planar silicon detector. Intense negative-ion-based hydrogen beam injectors created a large population of up to 160 keV energetic protons to react with the boron-injected plasma. The p-11B alpha particles having MeV energy were measured with the alpha particle detector which gave a fusion rate in a good agreement with the global p-11B alpha emission rate calculated based on classical confinement of energetic proton, using experimentally obtained plasma parameters.