The physical interaction between users and furniture is pivotal in determining comfort and functionality, particularly in environments where individuals spend extended periods, such as offices, homes, and public spaces. This study aims to analyze how different furniture designs impact user comfort, postural stability, and long-term usability. By employing a hybrid research framework combining observational studies, simulations, and advanced technological tools such as motion tracking, pressure mapping, and biomechanical sensors, the research provides a comprehensive evaluation of user-furniture interaction. The study involved 178 participants with diverse demographic backgrounds, allowing for a broad range of body types, ages, and activity levels to be examined. Key findings indicate that ergonomic features such as adjustable seat height, lumbar support, and reclining mechanisms significantly enhance comfort, particularly when customized to the user’s anthropometric profile. For example, adjustable seat height reduced pressure on the thighs, improving comfort by 8.5% over prolonged periods. Additionally, lumbar support was the most compelling feature in alleviating muscle strain, improving overall comfort by 9.0%. The analysis of long-term comfort revealed that postures supporting dynamic movements, such as using a standing desk, maintained higher comfort levels over time compared to static postures like leaning forward, which showed a marked increase in muscle fatigue. Postural stability analysis showed that sitting at a 90° angle provided the best balance of stability and long-term comfort, with a usability rating 8.4. In contrast, leaning forward exhibited the lowest postural stability and the highest discomfort, making it unsuitable for prolonged tasks.